Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase) - Rat Genome Database

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Gene: Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase) Mus musculus
Analyze
Symbol: Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
RGD ID: 1552179
MGI Page MGI
Description: Enables methionine synthase activity. Involved in cobalamin metabolic process. Acts upstream of or within methionine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-methyltetrahydrofolate--homocysteine methyltransferase; AI894170; cobalamin-dependent methionine synthase; D830038K18Rik; M; methionine synthase; MS; vitamin-B12 dependent methionine synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,196,217 - 12,273,090 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,197,598 - 12,272,999 (-)EnsemblGRCm39 Ensembl
GRCm381312,181,331 - 12,258,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,182,712 - 12,258,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,279,086 - 12,350,267 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,240,869 - 12,312,428 (-)NCBIMGSCv36mm8
Celera1312,106,428 - 12,177,671 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
5,6,7,8-tetrahydrofolic acid  (ISO)
5-methyltetrahydrofolic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benazepril  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butanal  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (ISO)
dinitrogen oxide  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
glutathione  (ISO)
glutathionylcobalamin  (ISO)
homocysteine  (ISO)
hydroxocobalamin  (ISO)
hypoxanthine  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylcobalamin  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP)
nitroprusside  (ISO)
paracetamol  (ISO)
phenylhydrazine  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thymidine  (ISO)
titanium dioxide  (EXP)
triazines  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
2. Vitamin B12 is a strong determinant of low methionine synthase activity and DNA hypomethylation in gastrectomized rats. Brunaud L, etal., Digestion. 2003;68(2-3):133-40. Epub 2003 Nov 28.
3. MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children. de Lima EL, etal., Pediatr Blood Cancer. 2010 Jul 1;54(7):904-8. doi: 10.1002/pbc.22472.
4. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Doolin MT, etal., Am J Hum Genet 2002 Nov;71(5):1222-6. Epub 2002 Oct 09.
5. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Gemmati D, etal., Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):787-94.
6. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
7. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
8. Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss. Gross M, etal., Audiol Neurootol. 2006;11(5):287-93. Epub 2006 Jun 14.
9. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk. Lima CS, etal., Leuk Res. 2008 Mar;32(3):401-5. Epub 2007 Jul 25.
10. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Aberrations in folate metabolic pathway and altered susceptibility to autism. Mohammad NS, etal., Psychiatr Genet. 2009 Aug;19(4):171-6.
14. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
15. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India. Nikbakht M, etal., Exp Oncol. 2012;34(1):43-8.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. Rouissi K, etal., Cancer Genet Cytogenet. 2009 Nov;195(1):43-53.
24. Germline genetic variation and treatment response on CCG-1891. Sepe DM, etal., Pediatr Blood Cancer. 2012 May;58(5):695-700. doi: 10.1002/pbc.23192. Epub 2011 May 25.
25. Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. Stover PJ J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
26. Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk. Suzuki T, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2742-7.
27. Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. Uchida Y, etal., BMC Med Genet. 2011 Mar 7;12:35. doi: 10.1186/1471-2350-12-35.
28. Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. Vujkovic M, etal., Leuk Res Rep. 2015 Jul 21;4(2):47-50. doi: 10.1016/j.lrr.2015.05.005. eCollection 2015.
29. [Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase, methionine synthase and the risk of pancreatic cancer] Wang L, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Jan;27(1):50-4.
30. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
31. Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Watkins D, etal., Am J Hum Genet. 2002 Jul;71(1):143-53. Epub 2002 May 30.
32. Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Williams KT and Schalinske KL, Diabetes Metab Res Rev. 2012 Feb;28(2):123-31. doi: 10.1002/dmrr.1281.
33. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. Williams KT, etal., J Nutr. 2008 Nov;138(11):2064-9. doi: 10.3945/jn.108.094144.
34. A candidate gene approach to genetic contributors to the development of IgA nephropathy. Yamamoto R, etal., Nephrol Dial Transplant. 2012 Mar;27(3):1020-30. doi: 10.1093/ndt/gfr369. Epub 2011 Jul 7.
35. D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. Zhang Y, etal., J Hum Genet. 2004;49(6):296-301. Epub 2004 May 18.
36. Polymorphism of methionine synthase gene in nuclear families of congenital heart disease. Zhu WL, etal., Biomed Environ Sci. 2004 Mar;17(1):57-64.
Additional References at PubMed
PMID:9321480   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11110696   PMID:11158293   PMID:11217851   PMID:11440986   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14681479  
PMID:16043641   PMID:16141072   PMID:16141073   PMID:16963246   PMID:17937387   PMID:18799693   PMID:19158324   PMID:21873635   PMID:22365888   PMID:26166573   PMID:30753104   PMID:32325033  
PMID:32554809   PMID:34702858   PMID:37174668  


Genomics

Comparative Map Data
Mtr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,196,217 - 12,273,090 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,197,598 - 12,272,999 (-)EnsemblGRCm39 Ensembl
GRCm381312,181,331 - 12,258,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,182,712 - 12,258,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,279,086 - 12,350,267 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,240,869 - 12,312,428 (-)NCBIMGSCv36mm8
Celera1312,106,428 - 12,177,671 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.52NCBI
MTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,795,281 - 236,903,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,795,260 - 236,921,278 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,958,581 - 237,067,281 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361235,025,341 - 235,130,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 341233,284,758 - 233,390,001NCBI
Celera1210,207,757 - 210,316,611 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,414,687 - 207,523,271 (+)NCBIHuRef
CHM1_11238,230,032 - 238,338,720 (+)NCBICHM1_1
T2T-CHM13v2.01236,206,330 - 236,315,021 (+)NCBIT2T-CHM13v2.0
Mtr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,911,705 - 62,996,544 (+)NCBIGRCr8
mRatBN7.21758,219,998 - 58,308,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,220,071 - 58,304,822 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,408,217 - 61,492,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,411,342 - 65,495,846 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,565,531 - 59,650,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,210,444 - 66,295,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,210,461 - 66,295,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,954,893 - 68,041,488 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,782,708 - 68,867,101 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,793,540 - 68,877,930 (+)NCBI
Celera1762,230,512 - 62,313,601 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Mtr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,376,512 - 3,474,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,372,915 - 3,474,173 (-)NCBIChiLan1.0ChiLan1.0
MTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,253,398 - 12,365,190 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,469,507 - 12,584,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,353,195 - 212,463,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,352,707 - 217,461,313 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,358,050 - 217,460,946 (+)Ensemblpanpan1.1panPan2
MTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,219,851 - 3,328,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,215,090 - 3,328,115 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,267,770 - 3,375,365 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,240,178 - 3,347,933 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,243,029 - 3,347,943 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,239,421 - 3,346,967 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,370,826 - 3,478,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,591,890 - 3,699,525 (-)NCBIUU_Cfam_GSD_1.0
Mtr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934439,925,911 - 40,014,880 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,087,923 - 16,180,148 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,087,924 - 16,180,089 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,546,978 - 54,652,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,546,978 - 54,652,780 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,497,706 - 58,627,105 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,935,666 - 74,039,872 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,935,225 - 74,038,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605576,034,340 - 76,141,359 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477513,792,043 - 13,896,559 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477513,791,690 - 13,903,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtr
2976 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:177
Interacting mature miRNAs:190
Transcripts:ENSMUST00000099856
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse

Markers in Region
AI894170  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381312,186,652 - 12,186,779UniSTSGRCm38
MGSCv371312,278,919 - 12,279,046UniSTSGRCm37
Celera1312,106,261 - 12,106,388UniSTS
Cytogenetic Map13A1UniSTS
cM Map135.0UniSTS
Whitehead/MRC_RH21823.33UniSTS
Mtr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map135.0UniSTS
cM Map135.0UniSTS
X83320  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381312,208,133 - 12,208,275UniSTSGRCm38
MGSCv371312,300,400 - 12,300,542UniSTSGRCm37
Celera1312,127,710 - 12,127,852UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Mtr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map135.0UniSTS
Mtr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000099856   ⟹   ENSMUSP00000097442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,197,598 - 12,272,981 (-)Ensembl
GRCm38.p6 Ensembl1312,182,712 - 12,258,095 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,201,424 - 12,215,376 (-)Ensembl
GRCm38.p6 Ensembl1312,186,538 - 12,200,490 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,204,315 - 12,215,373 (-)Ensembl
GRCm38.p6 Ensembl1312,189,429 - 12,200,487 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221290   ⟹   ENSMUSP00000152579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,231,766 - 12,272,999 (-)Ensembl
GRCm38.p6 Ensembl1312,216,880 - 12,258,113 (-)Ensembl
RefSeq Acc Id: NM_001081128   ⟹   NP_001074597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,201,424 - 12,272,999 (-)NCBI
GRCm381312,186,538 - 12,258,113 (-)NCBI
MGSCv371312,279,086 - 12,350,267 (-)RGD
Celera1312,106,147 - 12,177,784 (-)ENTREZGENE
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516661   ⟹   XP_006516724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,196,217 - 12,273,075 (-)NCBI
GRCm381312,181,331 - 12,258,189 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003950449
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,197,598 - 12,273,090 (-)NCBI
GRCm381312,186,529 - 12,258,199 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074597   ⟸   NM_001081128
- UniProtKB: Q3UQP2 (UniProtKB/Swiss-Prot),   A6H5Y3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516724   ⟸   XM_006516661
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000097442   ⟸   ENSMUST00000099856
Ensembl Acc Id: ENSMUSP00000152579   ⟸   ENSMUST00000221290
Protein Domains
AdoMet activation   B12-binding   B12-binding N-terminal   Hcy-binding   Pterin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6H5Y3-F1-model_v2 AlphaFold A6H5Y3 1-1253 view protein structure

Promoters
RGD ID:8679576
Promoter ID:EPDNEW_M17819
Type:initiation region
Name:Mtr_1
Description:Mus musculus 5-methyltetrahydrofolate-homocysteine methyltransferase, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381312,258,170 - 12,258,230EPDNEW
RGD ID:6824173
Promoter ID:MM_KWN:13224
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000099856
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361312,350,111 - 12,350,611 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894292 AgrOrtholog
Ensembl Genes ENSMUSG00000021311 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000099856 ENTREZGENE
  ENSMUST00000099856.6 UniProtKB/Swiss-Prot
  ENSMUST00000221290.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1240.10 UniProtKB/Swiss-Prot
  3.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.20 UniProtKB/Swiss-Prot
  3.20.20.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cobalamin-binding domain UniProtKB/Swiss-Prot
  Cobalamin-dependent Methionine Synthase, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cbl-bd_cap UniProtKB/Swiss-Prot
  Cobalamin-bd UniProtKB/Swiss-Prot
  Cobalamin-bd_sf UniProtKB/Swiss-Prot
  Dihydropteroate_synth-like UniProtKB/Swiss-Prot
  HCY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCY_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Met_Synthase/Corrinoid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Met_synthase_B12-bd UniProtKB/Swiss-Prot
  MetH UniProtKB/Swiss-Prot
  Meth_synthase_dom UniProtKB/Swiss-Prot
  Pterin-binding_dom UniProtKB/Swiss-Prot
  VitB12-dep_Met_synth_activ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitB12-dep_Met_synth_activ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:238505 UniProtKB/Swiss-Prot
MGD MGI:894292 ENTREZGENE
NCBI Gene Mtr ENTREZGENE
PANTHER METHIONINE SYNTHASE UniProtKB/Swiss-Prot
  METHIONINE SYNTHASE UniProtKB/Swiss-Prot
  METHIONINE SYNTHASE UniProtKB/TrEMBL
  METHIONINE SYNTHASE UniProtKB/TrEMBL
Pfam B12-binding UniProtKB/Swiss-Prot
  B12-binding_2 UniProtKB/Swiss-Prot
  Met_synt_B12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pterin_bind UniProtKB/Swiss-Prot
  S-methyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MTR RGD
PhenoGen Mtr PhenoGen
PIRSF MetH UniProtKB/Swiss-Prot
PROSITE ADOMET_ACTIVATION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B12_BINDING UniProtKB/Swiss-Prot
  B12_BINDING_NTER UniProtKB/Swiss-Prot
  HCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTERIN_BINDING UniProtKB/Swiss-Prot
SMART B12-binding_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47644 UniProtKB/Swiss-Prot
  SSF51717 UniProtKB/Swiss-Prot
  SSF52242 UniProtKB/Swiss-Prot
  SSF56507 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VM88_MOUSE UniProtKB/TrEMBL
  A6H5Y3 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UQP2 ENTREZGENE
  Q8BUC4_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UQP2 UniProtKB/Swiss-Prot