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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtrincreases activityISOMTR (Homo sapiens)6480464CTDDopamine results in increased activity of MTR proteinPMID:14745455
Mtrmultiple interactionsISOMTR (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; Ethanol promotes the reaction [Dopamine results in increased activity of MTR protein]; wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]PMID:14745455
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