Aia12 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Aia12 (Adjuvant induced arthritis QTL 12) Rattus norvegicus

Symbol: Aia12
Name: Adjuvant induced arthritis QTL 12
RGD ID: 2317054
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: left rear ankle joint diameter   (CMO:0002149)    
LOD Score: 4.24
P Value: Not Available
Variance: 11.0
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21738,281,509 - 83,281,509RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01741,176,057 - 86,176,057RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01742,940,774 - 87,940,774RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41749,069,974 - 94,069,974RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: F344/NCrl LEW/Crl 




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratinflammatory bowel disease  IAGP 2316974induced by peptidoglycan-polysaccharideRGD 
Aia12Ratrheumatoid arthritis  IAGP 2316974induced by peptidoglycan-polysaccharideRGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratjoint inflammation  IDA 2316974induced by peptidoglycan-polysaccharideRGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratleft rear ankle joint diameter  IDA 2316974 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratpeptidoglycan-polysaccharide  IDA 2316974 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratin vivo caliper method  IDA 2316974 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12RatF344/NCrl  IEA 2316974 RGD 
Aia12RatLEW/Crl  IEA 2316974 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia12Ratjoint integrity trait  IDA 2316974 RGD 


#
Reference Title
Reference Citation
1. Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD. Bleich A, etal., Inflamm Bowel Dis. 2009 Jun 12;15(12):1794-1802.


1 to 20 of 621 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
41196493Prelid1-ps2PRELI domain containing 1, pseudogene 2173882156238822894Rat
7624352LOC102547708uncharacterized LOC102547708173889286938924239Rat
41130148LOC120097912uncharacterized LOC120097912173905559039074794Rat
11436884Trnap-agg16transfer RNA proline (anticodon AGG) 16173919791739197991Rat
41214770Trnap-agg58transfer RNA proline (anticodon AGG) 58173938142739381499Rat
1596974Tpi1-ps2triosephosphate isomerase 1, pseudogene 2173962332439628409Rat
1307833Nrsn1neurensin 1173980623839824550Rat
1310227Dcdc2doublecortin domain containing 2173984595240031781Rat
7652139Rpl32-ps10ribosomal protein L32, pseudogene 10174003478840035377Rat
708529Mrs2magnesium transporter MRS2174006392440087073Rat
631371Gpld1glycosylphosphatidylinositol specific phospholipase D1174008442740132035Rat
621422Aldh5a1aldehyde dehydrogenase 5 family, member A1174013233940158677Rat
1307443Kiaa0319KIAA0319 homolog174016251240226666Rat
1587113Rpl37-ps1ribosomal protein L37, pseudogene 1174016749940167862Rat
1560342Tdp2tyrosyl-DNA phosphodiesterase 2174022894340240337Rat
1306513Acot13acyl-CoA thioesterase 13174024037840252851Rat
6491729C17h6orf62similar to human chromosome 6 open reading frame 62174025621140267851Rat
1308137Gmnngeminin, DNA replication inhibitor174030177140310054Rat
7707229Armh2armadillo-like helical domain containing 2174031731940321924Rat
41335353LOC120098024U2 spliceosomal RNA174032110540321289Rat

1 to 20 of 621 rows
1 to 20 of 683 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10348D17Mit4231176046341260463643Ratregion
10349D17Arb7237176046340560463642Ratregion
10350D17Wox12137176046350060463637Ratregion
10351D17Wox13150176046348360463633Ratregion
10490D5Uwm5171177589418175894750Ratregion
10709D17Mgh3112174142981541429923Ratregion
33790D17Mit3194175348176653481960Ratregion
33860D17Mit10231175523786855238103Ratregion
33939D17Mit11146177806876478068910Ratregion
34120D17Mgh597175090909950909196Ratregion
34122D17Mgh8157175090909650909253Ratregion
34391D17Mgh9148176811706768117215Ratregion
34645D17Pas1339175278466452785007Ratregion
33707D17Mit5281177085256570852846Ratregion
35985D17Rat20163173852519738525360Ratregion
36107D17Rat29178175336728153367459Ratregion
36211D17Rat34159176227078862270949Ratregion
36259D17Rat19155174022395240224109Ratregion
36315D17Rat41175176883571268835887Ratregion
36329D17Rat32119175583607655836425Ratregion
1 to 20 of 683 rows

Peak: (D17Rat151)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,781,426 - 60,781,592 (-)MAPPER
Rnor_6.01763,675,975 - 63,676,140NCBI
Rnor_5.01765,440,692 - 65,440,857UniSTS
RGSC_v3.41771,569,891 - 71,570,057RGD
RGSC_v3.41771,569,892 - 71,570,057UniSTS
RGSC_v3.11771,580,725 - 71,580,890RGD
RH 3.4 Map17587.2RGD
RH 3.4 Map17587.2UniSTS
RH 2.0 Map17499.9RGD
SHRSP x BN Map1732.6599RGD
Cytogenetic Map17q12.1UniSTS


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat

1 to 10 of 72 rows


Note Type Note Reference
qtl_general inducing agent: peptidoglycan-polysaccharide (PG-PS) polymers 2316974
qtl_general software used: MapQTL software, Student's t-tests, median tests 2316974
qtl_general measurement method: animals were anesthetized, intestines exposed and 0.05 mL PG-PS suspension was injected; after 24 days these animals were exsanguinated and joint diameter of the left rear ankle measured on 21st day of the treatment 2316974
qtl_general number of animals used: 168 F2 females 2316974