Cdnf (cerebral dopamine neurotrophic factor) - Rat Genome Database

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Gene: Cdnf (cerebral dopamine neurotrophic factor) Rattus norvegicus
Analyze
Symbol: Cdnf
Name: cerebral dopamine neurotrophic factor
RGD ID: 1307600
Description: Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be active in endoplasmic reticulum and extracellular space. Orthologous to human CDNF (cerebral dopamine neurotrophic factor); INTERACTS WITH agathisflavone; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; ARMET-like protein 1; Armetl1; conserved dopamine neurotrophic factor; LOC361276
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81779,623,728 - 79,637,800 (-)NCBIGRCr8
mRatBN7.21774,714,564 - 74,728,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1774,713,564 - 74,728,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1778,167,908 - 78,181,939 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,016,045 - 82,030,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,051,344 - 76,065,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01778,721,230 - 78,735,324 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,719,111 - 78,735,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01780,366,184 - 80,379,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41785,834,236 - 85,848,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11785,845,068 - 85,859,120 (-)NCBI
Celera1774,100,626 - 74,114,537 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdnfRathypoparathyroidism-deafness-renal disease syndrome  ISOCDNF (Homo sapiens)8554872ClinVar Annotator: match by term: Hypoparathyroidism more ...ClinVarPMID:25741868

1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdnfRat1,2-dimethylhydrazine decreases expressionISOCdnf (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CDNF mRNACTDPMID:22206623
CdnfRatacrylamide increases expressionISOCDNF (Homo sapiens)6480464Acrylamide results in increased expression of CDNF mRNACTDPMID:32763439
CdnfRatagathisflavone increases expressionEXP 6480464agathisflavone results in increased expression of CDNF mRNACTDPMID:29425760
CdnfRatalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of CDNF mRNACTDPMID:35163327
CdnfRatalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of CDNF mRNACTDPMID:35163327
CdnfRatarsenous acid multiple interactionsISOCDNF (Homo sapiens)6480464Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CDNF protein]CTDPMID:26598702
CdnfRatbenzo[a]pyrene decreases expressionISOCdnf (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of CDNF mRNACTDPMID:22228805
CdnfRatbenzo[a]pyrene decreases expressionISOCDNF (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of CDNF mRNACTDPMID:32234424
CdnfRatbis(2-ethylhexyl) phthalate decreases expressionISOCDNF (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of CDNF mRNACTDPMID:31163220
CdnfRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CDNF mRNACTDPMID:25181051
CdnfRatcantharidin decreases expressionISOCdnf (Mus musculus)6480464Cantharidin results in decreased expression of CDNF mRNACTDPMID:36907384
CdnfRatcisplatin multiple interactionsISOCDNF (Homo sapiens)6480464[Cisplatin co-treated with jinfukang] results in increased expression of CDNF mRNACTDPMID:27392435
CdnfRatcisplatin increases expressionISOCDNF (Homo sapiens)6480464Cisplatin results in increased expression of CDNF mRNACTDPMID:27392435
CdnfRatcyclosporin A decreases methylationISOCDNF (Homo sapiens)6480464Cyclosporine results in decreased methylation of CDNF promoterCTDPMID:27989131
CdnfRatdiarsenic trioxide multiple interactionsISOCDNF (Homo sapiens)6480464Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CDNF protein]CTDPMID:26598702
CdnfRatepoxiconazole increases expressionISOCdnf (Mus musculus)6480464epoxiconazole results in increased expression of CDNF mRNACTDPMID:35436446
CdnfRatiron dichloride decreases expressionISOCDNF (Homo sapiens)6480464ferrous chloride results in decreased expression of CDNF mRNACTDPMID:35984750
CdnfRatketamine affects expressionISOCdnf (Mus musculus)6480464Ketamine affects the expression of CDNF mRNACTDPMID:35728656
CdnfRatlipopolysaccharide multiple interactionsISOCDNF (Homo sapiens)6480464[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CDNF mRNACTDPMID:35811015
CdnfRatmanganese(II) chloride increases expressionEXP 6480464manganese chloride results in increased expression of CDNF mRNACTDPMID:28801915

1 to 20 of 29 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdnfRatdopaminergic neuron differentiation involved_inIBAPANTHER:PTN000312771 and ZFIN:ZDB-GENE-060929-6401600115GO_REF:0000033GO_CentralGO_REF:0000033
CdnfRatneuron projection development involved_inIBAFB:FBgn0027095 and PANTHER:PTN0003127711600115GO_REF:0000033GO_CentralGO_REF:0000033
CdnfRatsignal transduction involved_inIEAGO:00080831600115GO_REF:0000108GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdnfRatendoplasmic reticulum is_active_inIBAFB:FBgn0027095 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
CdnfRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
CdnfRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
CdnfRatextracellular space is_active_inIBAPANTHER:PTN000312771 and Manf (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdnfRatgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:21235575   PMID:23624196   PMID:26271594   PMID:28553166   PMID:33154393  



Cdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81779,623,728 - 79,637,800 (-)NCBIGRCr8
mRatBN7.21774,714,564 - 74,728,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1774,713,564 - 74,728,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1778,167,908 - 78,181,939 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,016,045 - 82,030,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,051,344 - 76,065,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01778,721,230 - 78,735,324 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,719,111 - 78,735,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01780,366,184 - 80,379,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41785,834,236 - 85,848,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11785,845,068 - 85,859,120 (-)NCBI
Celera1774,100,626 - 74,114,537 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
CDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381014,819,245 - 14,838,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1014,819,245 - 14,838,575 (-)EnsemblGRCh38hg38GRCh38
GRCh371014,861,244 - 14,880,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361014,901,257 - 14,919,989 (-)NCBINCBI36Build 36hg18NCBI36
Celera1014,789,300 - 14,808,023 (-)NCBICelera
Cytogenetic Map10p13NCBI
HuRef1014,771,897 - 14,790,630 (-)NCBIHuRef
CHM1_11014,861,668 - 14,880,382 (-)NCBICHM1_1
T2T-CHM13v2.01014,833,219 - 14,852,002 (-)NCBIT2T-CHM13v2.0
Cdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3923,514,102 - 3,527,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl23,514,067 - 3,527,413 (+)EnsemblGRCm39 Ensembl
GRCm3823,513,065 - 3,526,376 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl23,513,030 - 3,526,376 (+)EnsemblGRCm38mm10GRCm38
MGSCv3723,430,337 - 3,443,648 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3623,430,337 - 3,443,648 (+)NCBIMGSCv36mm8
Celera23,463,708 - 3,477,022 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map21.99NCBI
Cdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542919,583,041 - 19,593,792 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542919,586,841 - 19,592,727 (+)NCBIChiLan1.0ChiLan1.0
CDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2827,345,792 - 27,363,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11027,351,120 - 27,369,213 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01014,823,105 - 14,841,698 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11015,151,359 - 15,169,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1015,151,359 - 15,169,689 (-)Ensemblpanpan1.1panPan2
CDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,795,701 - 21,814,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl221,795,821 - 21,814,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha218,909,001 - 18,927,647 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0222,097,384 - 22,116,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl222,097,349 - 22,116,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1219,297,755 - 19,316,135 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0220,132,502 - 20,150,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0220,759,161 - 20,777,858 (+)NCBIUU_Cfam_GSD_1.0
Cdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093446,836,052 - 6,855,784 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366131,387,568 - 1,406,370 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366131,386,249 - 1,406,295 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11046,935,530 - 46,963,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21051,667,672 - 51,687,019 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1914,843,382 - 14,860,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl914,842,990 - 14,861,013 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605120,381,826 - 20,399,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Cdnf
107 total Variants

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000036299
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat

1 to 10 of 25 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 77 76 45 25 45 6 204 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000036299   ⟹   ENSRNOP00000030751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1774,713,564 - 74,728,639 (-)Ensembl
Rnor_6.0 Ensembl1778,719,111 - 78,735,324 (-)Ensembl
RefSeq Acc Id: NM_001037543   ⟹   NP_001032632
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81779,623,728 - 79,637,800 (-)NCBI
mRatBN7.21774,714,564 - 74,728,639 (-)NCBI
Rnor_6.01778,721,230 - 78,735,324 (-)NCBI
Rnor_5.01780,366,184 - 80,379,144 (-)NCBI
RGSC_v3.41785,834,236 - 85,848,287 (-)RGD
Celera1774,100,626 - 74,114,537 (-)RGD
Sequence:
Protein RefSeqs NP_001032632 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78688 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030751
  ENSRNOP00000030751.2
GenBank Protein P0C5I0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032632   ⟸   NM_001037543
- Peptide Label: precursor
- UniProtKB: P0C5I0 (UniProtKB/Swiss-Prot),   A6JM11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030751   ⟸   ENSRNOT00000036299
ARMET C-terminal   ARMET N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P0C5I0-F1-model_v2 AlphaFold P0C5I0 1-187 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700579
Promoter ID:EPDNEW_R11103
Type:single initiation site
Name:Cdnf_1
Description:cerebral dopamine neurotrophic factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01778,735,342 - 78,735,402EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-8654 BioCyc
Ensembl Genes ENSRNOG00000026493 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036299 ENTREZGENE
  ENSRNOT00000036299.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot
  Saposin-like UniProtKB/Swiss-Prot
InterPro ARMET-like UniProtKB/Swiss-Prot
  ARMET_N UniProtKB/Swiss-Prot
  Armet_prot UniProtKB/Swiss-Prot
  SAP_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:361276 UniProtKB/Swiss-Prot
NCBI Gene 361276 ENTREZGENE
PANTHER CEREBRAL DOPAMINE NEUROTROPHIC FACTOR UniProtKB/Swiss-Prot
  PTHR12990 UniProtKB/Swiss-Prot
Pfam Armet UniProtKB/Swiss-Prot
  ARMET_N UniProtKB/Swiss-Prot
PhenoGen Cdnf PhenoGen
RatGTEx ENSRNOG00000026493 RatGTEx
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot
UniProt A6JM11 ENTREZGENE, UniProtKB/TrEMBL
  CDNF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-09-17 Cdnf  cerebral dopamine neurotrophic factor  Armetl1  arginine-rich, mutated in early stage tumors-like 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Armetl1  arginine-rich, mutated in early stage tumors-like 1   Armetl1_predicted  arginine-rich, mutated in early stage tumors-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Armetl1_predicted  arginine-rich, mutated in early stage tumors-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED