Gene: Itga8 (integrin subunit alpha 8) Rattus norvegicus
Analyze
Symbol:
Itga8
Name:
integrin subunit alpha 8
Description:
Involved in brain development. Localizes to dendritic spine membrane; perikaryon; and postsynaptic density. Biomarker of mesangial proliferative glomerulonephritis. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8); PARTICIPATES IN altered integrin mediated signaling pathway; glomerulonephritis pathway; integrin mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2-nitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
integrin alpha 8; integrin alpha-8; integrin, alpha 8; LOC364786; RGD1564327; similar to integrin alpha 8
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ITGA8 (integrin subunit alpha 8) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Itga8 (integrin alpha 8) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Itga8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ITGA8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ITGA8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Itga8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ITGA8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ITGA8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Itga8 (integrin subunit alpha 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ITGAV (integrin subunit alpha V) HGNC
OrthoMCL
Homo sapiens (human):
ITGA2B (integrin subunit alpha 2b) HGNC
OrthoMCL
Homo sapiens (human):
ITGA5 (integrin subunit alpha 5) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
ITGA8 (integrin subunit alpha 8)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Itga8 (integrin alpha 8)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
pat-2
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Drosophila melanogaster (fruit fly):
if
Alliance
DIOPT (PANTHER|Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 17 79,321,893 - 79,676,927 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 79,321,900 - 79,676,499 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 81,190,818 - 81,304,978 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 17 80,956,109 - 81,030,622 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 86,427,191 - 86,649,268 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera 17 74,681,231 - 74,877,691 (-) NCBI Celera Cytogenetic Map 17 q12.3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
hypoparathyroidism-deafness-renal disease syndrome ISO RGD:736147 8554872 ClinVar Annotator: match by term: Barakat syndrome ClinVar PMID:25741868 Renal Hypodysplasia/Aplasia 1 ISO RGD:736147 8554872 ClinVar Annotator: match by term: Renal hypodysplasia/aplasia 1 ClinVar PMID:24439109 Renal Hypodysplasia/Aplasia 1 ISO RGD:736147 8554872 ClinVar Annotator: match by term: Renal hypodysplasia/aplasia 1 ClinVar PMID:25741868
Imported Annotations - CTD
Ovarian Neoplasms ISO RGD:736147 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17303177 renal agenesis ISO RGD:736147 11554173 CTD Direct Evidence: marker/mechanism CTD Stomach Neoplasms ISO RGD:736147 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17786296 Imported Annotations - OMIM
Renal Hypodysplasia/Aplasia 1 ISO RGD:736147 7240710 OMIM
1,1-dichloroethene decreases expression ISO RGD:736148 6480464 vinylidene chloride results in decreased expression of ITGA8 mRNA CTD PMID:26682919 1,2-dichloroethane decreases expression ISO RGD:736148 6480464 ethylene dichloride results in decreased expression of ITGA8 mRNA CTD PMID:28960355 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of ITGA8 mRNA CTD PMID:30723492 17beta-estradiol multiple interactions ISO RGD:736147 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of ITGA8 mRNA CTD PMID:20226447 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of ITGA8 mRNA CTD PMID:26496021 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736148 6480464 Tetrachlorodibenzodioxin affects the expression of ITGA8 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736148 6480464 Tetrachlorodibenzodioxin results in decreased expression of ITGA8 mRNA CTD PMID:26290441 2-nitrotoluene decreases expression EXP 6480464 2-nitrotoluene results in decreased expression of ITGA8 mRNA CTD PMID:16460773 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:32119087 4,4'-sulfonyldiphenol increases expression ISO RGD:736148 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of ITGA8 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol multiple interactions ISO RGD:736148 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of ITGA8 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:736148 6480464 Fenretinide results in increased expression of ITGA8 mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide decreases expression ISO RGD:736148 6480464 Fenretinide results in decreased expression of ITGA8 mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ITGA8 mRNA CTD PMID:24780913 acetaldehyde affects expression ISO RGD:736148 6480464 Acetaldehyde affects the expression of ITGA8 mRNA CTD PMID:22634333 acetamide increases expression EXP 6480464 acetamide results in increased expression of ITGA8 mRNA CTD PMID:31881176 aflatoxin B1 increases methylation ISO RGD:736147 6480464 Aflatoxin B1 results in increased methylation of ITGA8 exon, Aflatoxin B1 results in increased methylation of ITGA8 intron CTD PMID:30157460 aflatoxin B1 decreases expression ISO RGD:736147 6480464 Aflatoxin B1 results in decreased expression of ITGA8 mRNA CTD PMID:32234424 all-trans-retinoic acid increases expression ISO RGD:736147 6480464 Tretinoin results in increased expression of ITGA8 mRNA CTD PMID:21934132 all-trans-retinoic acid multiple interactions ISO RGD:736148 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of ITGA8 mRNA, [bisphenol A co-treated with Tretinoin] results in decreased expression of ITGA8 mRNA CTD PMID:30951980 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ITGA8 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:736147 6480464 Antirheumatic Agents results in increased expression of ITGA8 mRNA CTD PMID:24449571 arsane decreases expression ISO RGD:736148 6480464 Arsenic results in decreased expression of ITGA8 mRNA CTD PMID:19654921 arsane affects methylation ISO RGD:736147 6480464 Arsenic affects the methylation of ITGA8 gene CTD PMID:25304211 arsenic atom decreases expression ISO RGD:736148 6480464 Arsenic results in decreased expression of ITGA8 mRNA CTD PMID:19654921 arsenic atom affects methylation ISO RGD:736147 6480464 Arsenic affects the methylation of ITGA8 gene CTD PMID:25304211 arsenite(3-) increases methylation ISO RGD:736147 6480464 arsenite results in increased methylation of ITGA8 promoter CTD PMID:23974009 astemizole increases expression EXP 6480464 Astemizole results in increased expression of ITGA8 mRNA CTD PMID:20221588 benzo[a]pyrene affects methylation ISO RGD:736147 6480464 Benzo(a)pyrene affects the methylation of ITGA8 exon CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:736147 6480464 Benzo(a)pyrene results in decreased expression of ITGA8 mRNA CTD PMID:32234424 benzo[a]pyrene diol epoxide I increases expression ISO RGD:736147 6480464 7 more ... CTD PMID:20382639 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGA8 mRNA CTD PMID:18164116 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of ITGA8 mRNA CTD PMID:26496021 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ITGA8 mRNA CTD PMID:30816183 bisphenol A increases expression ISO RGD:736148 6480464 bisphenol A results in increased expression of ITGA8 mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO RGD:736148 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of ITGA8 mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:736147 6480464 bisphenol A results in increased expression of ITGA8 mRNA CTD PMID:29275510 bisphenol A decreases expression ISO RGD:736147 6480464 bisphenol A results in decreased expression of ITGA8 mRNA CTD PMID:27685785 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ITGA8 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:736148 6480464 bisphenol F results in increased expression of ITGA8 mRNA CTD PMID:30951980 bromochloroacetic acid decreases expression EXP 6480464 bromochloroacetic acid results in decreased expression of ITGA8 mRNA CTD PMID:16460773 carbon nanotube decreases expression ISO RGD:736148 6480464 Nanotubes, Carbon analog results in decreased expression of ITGA8 mRNA, Nanotubes, Carbon results in decreased expression of ITGA8 mRNA CTD PMID:25554681 , PMID:25620056 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of ITGA8 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:736148 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA8 mRNA CTD PMID:20938992 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of ITGA8 mRNA CTD PMID:15755911 cyproconazole increases expression ISO RGD:736148 6480464 cyproconazole results in increased expression of ITGA8 mRNA CTD PMID:22045034 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of ITGA8 mRNA CTD PMID:23640034 dioxygen multiple interactions ISO RGD:736148 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ITGA8 mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of ITGA8 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:736148 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ITGA8 mRNA CTD PMID:30517762 flusilazole affects expression ISO RGD:736148 6480464 flusilazole affects the expression of ITGA8 mRNA CTD PMID:22634333 folic acid multiple interactions ISO RGD:736148 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA8 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of ITGA8 mRNA CTD PMID:27387713 L-methionine multiple interactions ISO RGD:736148 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA8 mRNA CTD PMID:20938992 Lasiocarpine decreases expression ISO RGD:736147 6480464 lasiocarpine results in decreased expression of ITGA8 mRNA CTD PMID:32234424 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of ITGA8 mRNA CTD PMID:28801915 manganese(II) chloride increases methylation EXP 6480464 manganese chloride results in increased methylation of ITGA8 gene CTD PMID:28801915 mercury dibromide increases expression ISO RGD:736147 6480464 mercuric bromide results in increased expression of ITGA8 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 N-methyl-4-phenylpyridinium increases methylation EXP 6480464 1-Methyl-4-phenylpyridinium results in increased methylation of ITGA8 gene CTD PMID:28801915 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of ITGA8 mRNA CTD PMID:28801915 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGA8 mRNA more ... CTD PMID:18164116 , PMID:25374375 nickel atom decreases expression ISO RGD:736147 6480464 Nickel results in decreased expression of ITGA8 mRNA CTD PMID:24768652 , PMID:25583101 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of ITGA8 mRNA, nitrofen results in decreased expression of ITGA8 protein CTD PMID:28701000 O-methyleugenol decreases expression ISO RGD:736147 6480464 methyleugenol results in decreased expression of ITGA8 mRNA CTD PMID:32234424 panobinostat increases expression ISO RGD:736147 6480464 panobinostat results in increased expression of ITGA8 mRNA CTD PMID:26272509 panobinostat multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 paracetamol affects expression ISO RGD:736148 6480464 Acetaminophen affects the expression of ITGA8 mRNA CTD PMID:17562736 phenobarbital multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased methylation of ITGA8 promoter, [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ITGA8 mRNA CTD PMID:25374375 phenylmercury acetate increases expression ISO RGD:736147 6480464 Phenylmercuric Acetate results in increased expression of ITGA8 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 phenytoin increases expression ISO RGD:736147 6480464 Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 pioglitazone multiple interactions ISO RGD:736148 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ITGA8 mRNA CTD PMID:27935865 pirinixic acid increases expression ISO RGD:736148 6480464 pirinixic acid results in increased expression of ITGA8 mRNA CTD PMID:23811191 progesterone multiple interactions ISO RGD:736147 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of ITGA8 mRNA CTD PMID:20226447 progesterone increases expression EXP 6480464 Progesterone results in increased expression of ITGA8 mRNA CTD PMID:20726854 SB 431542 multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:736147 6480464 Silicon Dioxide analog results in increased expression of ITGA8 mRNA CTD PMID:23806026 silicon dioxide decreases expression ISO RGD:736148 6480464 Silicon Dioxide results in decreased expression of ITGA8 mRNA CTD PMID:23221170 tetrachloromethane affects expression ISO RGD:736148 6480464 Carbon Tetrachloride affects the expression of ITGA8 mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO RGD:736148 6480464 Carbon Tetrachloride results in increased expression of ITGA8 mRNA CTD PMID:29987408 tetrachloromethane multiple interactions ISO RGD:736148 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ITGA8 mRNA CTD PMID:30517762 trichostatin A increases expression ISO RGD:736147 6480464 trichostatin A results in increased expression of ITGA8 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 trimellitic anhydride decreases expression ISO RGD:736148 6480464 trimellitic anhydride results in decreased expression of ITGA8 mRNA CTD PMID:19042947 valproic acid decreases expression ISO RGD:736148 6480464 Valproic Acid results in decreased expression of ITGA8 mRNA CTD PMID:22045034 valproic acid increases expression ISO RGD:736148 6480464 Valproic Acid results in increased expression of ITGA8 mRNA CTD PMID:24896083 valproic acid increases expression ISO RGD:736147 6480464 Valproic Acid results in increased expression of ITGA8 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 vorinostat multiple interactions ISO RGD:736147 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA8 mRNA CTD PMID:27188386 vorinostat increases expression ISO RGD:736147 6480464 vorinostat results in increased expression of ITGA8 mRNA CTD PMID:26272509
Gene-Chemical Interaction Annotations
