Itga8 (integrin subunit alpha 8) - Rat Genome Database

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Gene: Itga8 (integrin subunit alpha 8) Rattus norvegicus
Analyze
Symbol: Itga8
Name: integrin subunit alpha 8
RGD ID: 621634
Description: Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including inner ear morphogenesis; memory; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in dendritic spine membrane and perikaryon. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of mesangial proliferative glomerulonephritis. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8); PARTICIPATES IN glomerulonephritis pathway; altered integrin mediated signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: integrin alpha 8; integrin alpha-8; integrin, alpha 8; LOC364786; RGD1564327; similar to integrin alpha 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81780,213,139 - 80,410,633 (-)NCBIGRCr8
mRatBN7.21775,304,004 - 75,501,510 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1778,764,688 - 78,961,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,600,048 - 82,796,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,647,995 - 76,844,433 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01779,321,893 - 79,676,927 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1779,321,900 - 79,676,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01780,956,109 - 81,030,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01781,190,818 - 81,304,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41786,427,191 - 86,649,268 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1774,681,231 - 74,877,691 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
furan  (EXP)
glycine betaine  (ISO)
inulin  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methylarsonic acid  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Cai LY, etal., Life Sci. 2007 Mar 27;80(16):1458-65. Epub 2007 Jan 20.
2. Regional and ultrastructural distribution of the alpha 8 integrin subunit in developing and adult rat brain suggests a role in synaptic function. Einheber S, etal., J Comp Neurol. 1996 Jun 17;370(1):105-34.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. Hartner A, etal., Kidney Int 1999 Oct;56(4):1468-80.
6. Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Marek I, etal., Cell Adh Migr. 2014;8(4):389-95. doi: 10.4161/cam.28988.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Müller U, etal., Cell. 1997 Mar 7;88(5):603-13. doi: 10.1016/s0092-8674(00)81903-0.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients. Supriyanto I, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:347-52. doi: 10.1016/j.pnpbp.2012.11.002. Epub 2012 Nov 12.
16. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
17. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Zeltner R, etal., Nephron Clin Pract. 2008;108(3):c169-75. doi: 10.1159/000116887. Epub 2008 Feb 14.
Additional References at PubMed
PMID:10742111   PMID:12477932   PMID:12904471   PMID:17275006   PMID:17300786   PMID:17537792   PMID:21335239   PMID:21423176   PMID:23154389   PMID:24439109   PMID:28701000  


Genomics

Comparative Map Data
Itga8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81780,213,139 - 80,410,633 (-)NCBIGRCr8
mRatBN7.21775,304,004 - 75,501,510 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1778,764,688 - 78,961,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,600,048 - 82,796,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,647,995 - 76,844,433 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01779,321,893 - 79,676,927 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1779,321,900 - 79,676,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01780,956,109 - 81,030,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01781,190,818 - 81,304,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41786,427,191 - 86,649,268 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1774,681,231 - 74,877,691 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
ITGA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381015,513,954 - 15,719,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1015,513,954 - 15,719,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371015,555,953 - 15,761,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361015,599,094 - 15,801,776 (-)NCBINCBI36Build 36hg18NCBI36
Build 341015,599,093 - 15,801,776NCBI
Celera1015,492,319 - 15,695,021 (-)NCBICelera
Cytogenetic Map10p13NCBI
HuRef1015,471,650 - 15,674,184 (-)NCBIHuRef
CHM1_11015,559,210 - 15,761,820 (-)NCBICHM1_1
T2T-CHM13v2.01015,531,985 - 15,737,921 (-)NCBIT2T-CHM13v2.0
Itga8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39212,111,443 - 12,306,755 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl212,111,443 - 12,306,733 (-)EnsemblGRCm39 Ensembl
GRCm38212,106,632 - 12,301,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl212,106,632 - 12,301,922 (-)EnsemblGRCm38mm10GRCm38
MGSCv37212,028,287 - 12,223,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36212,024,513 - 12,219,773 (-)NCBIMGSCv36mm8
Celera212,022,433 - 12,215,417 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map29.12NCBI
Itga8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542911,932,570 - 12,120,821 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542911,932,764 - 12,120,757 (+)NCBIChiLan1.0ChiLan1.0
ITGA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2828,363,781 - 28,573,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11028,369,106 - 28,578,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01015,838,320 - 16,045,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11016,114,999 - 16,321,277 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1016,114,999 - 16,321,360 (-)Ensemblpanpan1.1panPan2
ITGA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,034,630 - 21,244,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl221,075,653 - 21,241,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha218,185,585 - 18,354,528 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0221,368,356 - 21,544,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl221,368,171 - 21,542,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1218,574,970 - 18,744,463 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0219,409,413 - 19,578,983 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0220,034,706 - 20,203,972 (+)NCBIUU_Cfam_GSD_1.0
Itga8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934416,485,714 - 16,655,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365745,984,939 - 6,155,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365745,985,181 - 6,155,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1046,132,913 - 46,303,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11046,132,887 - 46,303,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21050,827,993 - 51,000,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1915,482,746 - 15,684,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl915,482,750 - 15,683,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605121,068,023 - 21,273,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479611,908,964 - 12,101,139 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479611,908,927 - 12,103,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga8
1519 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:864
Count of miRNA genes:313
Interacting mature miRNAs:422
Transcripts:ENSRNOT00000022711
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
RH131175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21775,304,110 - 75,304,312 (+)MAPPERmRatBN7.2
Rnor_6.01779,322,003 - 79,322,204NCBIRnor6.0
Rnor_5.01780,956,216 - 80,956,417UniSTSRnor5.0
RGSC_v3.41786,427,302 - 86,427,503UniSTSRGSC3.4
Celera1774,681,338 - 74,681,539UniSTS
RH 3.4 Map17763.4UniSTS
Cytogenetic Map17q12.3UniSTS
BE120177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21775,463,133 - 75,463,301 (+)MAPPERmRatBN7.2
Rnor_6.01779,637,105 - 79,637,272NCBIRnor6.0
Rnor_5.01781,266,161 - 81,266,328UniSTSRnor5.0
RGSC_v3.41786,610,426 - 86,610,593UniSTSRGSC3.4
Celera1774,840,425 - 74,840,592UniSTS
RH 3.4 Map17765.5UniSTS
Cytogenetic Map17q12.3UniSTS
MARC_50801-50802:1130354928:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21775,500,497 - 75,500,715 (+)MAPPERmRatBN7.2
Rnor_6.01779,675,487 - 79,675,704NCBIRnor6.0
Rnor_5.01781,303,966 - 81,304,183UniSTSRnor5.0
RGSC_v3.41786,648,262 - 86,648,479UniSTSRGSC3.4
Celera1774,876,679 - 74,876,896UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022711   ⟹   ENSRNOP00000022713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)Ensembl
Rnor_6.0 Ensembl1779,321,900 - 79,676,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097386   ⟹   ENSRNOP00000076706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119561   ⟹   ENSRNOP00000090641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)Ensembl
RefSeq Acc Id: NM_001173972   ⟹   NP_001167443
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81780,213,139 - 80,410,633 (-)NCBI
mRatBN7.21775,304,004 - 75,501,510 (-)NCBI
Rnor_6.01779,321,896 - 79,676,499 (-)NCBI
Rnor_5.01780,956,109 - 81,030,622 (-)NCBI
Rnor_5.01781,190,818 - 81,304,978 (-)NCBI
Celera1774,681,231 - 74,877,691 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001167443   ⟸   NM_001173972
- UniProtKB: B5DEG1 (UniProtKB/TrEMBL),   F7F1E3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022713   ⟸   ENSRNOT00000022711
Ensembl Acc Id: ENSRNOP00000076706   ⟸   ENSRNOT00000097386
Ensembl Acc Id: ENSRNOP00000090641   ⟸   ENSRNOT00000119561
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEG1-F1-model_v2 AlphaFold B5DEG1 1-1062 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700589
Promoter ID:EPDNEW_R11113
Type:initiation region
Name:Itga8_1
Description:integrin subunit alpha 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01779,676,510 - 79,676,570EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621634 AgrOrtholog
BioCyc Gene G2FUF-8635 BioCyc
Ensembl Genes ENSRNOG00000016538 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022711.5 UniProtKB/TrEMBL
  ENSRNOT00000097386.1 UniProtKB/TrEMBL
  ENSRNOT00000119561.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
KEGG Report rno:364786 UniProtKB/TrEMBL
NCBI Gene Itga8 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-8 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itga8 PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016538 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8I5Y696_RAT UniProtKB/TrEMBL
  A0A8I6GID8_RAT UniProtKB/TrEMBL
  B5DEG1 ENTREZGENE, UniProtKB/TrEMBL
  F7F1E3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga8  integrin subunit alpha 8  Itga8  integrin, alpha 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-26 Itga8  integrin, alpha 8  RGD1564327  similar to integrin alpha 8  Data merged from RGD:1564327 737654 APPROVED
2010-02-09 Itga8  integrin, alpha 8  Itga8  integrin alpha 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564327  similar to integrin alpha 8   RGD1564327_predicted  similar to integrin alpha 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564327_predicted  similar to integrin alpha 8 (predicted)  LOC364786  similar to integrin alpha 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC364786  similar to integrin alpha 8      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Itga8  integrin alpha 8      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Itga8  integrin alpha 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression strongly and solely expressed in mesangial cells in glomeruli and renal vasculature 633055