Trim38 (tripartite motif containing 38) - Rat Genome Database

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Gene: Trim38 (tripartite motif containing 38) Rattus norvegicus
Analyze
Symbol: Trim38
Name: tripartite motif containing 38
RGD ID: 1596868
Description: Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of viral entry into host cell. Predicted to act upstream of or within several processes, including negative regulation of defense response to virus; positive regulation of viral genome replication; and protein K48-linked ubiquitination. Orthologous to human TRIM38 (tripartite motif containing 38); INTERACTS WITH (S)-colchicine (ortholog); 1,2-dichloroethane (ortholog); 2-palmitoylglycerol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase TRIM38; LOC680019; similar to tripartite motif-containing 38
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,774,419 - 41,787,709 (-)NCBIGRCr8
mRatBN7.21741,351,857 - 41,365,021 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01743,600,006 - 43,607,879 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01745,454,492 - 45,462,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,533,590 - 48,541,164 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1740,983,646 - 40,991,519 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12761501   PMID:18248090   PMID:22539786   PMID:23077300   PMID:36061751  


Genomics

Comparative Map Data
Trim38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,774,419 - 41,787,709 (-)NCBIGRCr8
mRatBN7.21741,351,857 - 41,365,021 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01743,600,006 - 43,607,879 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01745,454,492 - 45,462,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,533,590 - 48,541,164 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1740,983,646 - 40,991,519 (-)NCBICelera
Cytogenetic Map17p11NCBI
TRIM38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38625,962,802 - 25,991,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl625,962,802 - 25,991,231 (+)EnsemblGRCh38hg38GRCh38
GRCh37625,963,030 - 25,991,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,071,050 - 26,093,337 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,071,049 - 26,093,329NCBI
Celera627,190,286 - 27,212,582 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef625,905,972 - 25,930,614 (+)NCBIHuRef
CHM1_1625,965,160 - 25,989,826 (+)NCBICHM1_1
T2T-CHM13v2.0625,828,703 - 25,857,166 (+)NCBIT2T-CHM13v2.0
Trim38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,962,483 - 23,975,721 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,953,896 - 23,975,511 (+)EnsemblGRCm39 Ensembl
GRCm381323,778,500 - 23,791,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,769,913 - 23,791,528 (+)EnsemblGRCm38mm10GRCm38
MGSCv371323,874,441 - 23,883,364 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,790,037 - 23,798,960 (+)NCBIMGSCv36mm8
Celera1324,014,284 - 24,023,174 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.92NCBI
TRIM38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2540,608,603 - 40,630,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1636,610,178 - 36,647,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0625,796,278 - 25,818,610 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,454,051 - 26,475,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,454,051 - 26,475,842 (+)Ensemblpanpan1.1panPan2
TRIM38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13523,894,521 - 23,939,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3523,926,287 - 23,939,466 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3523,805,035 - 23,818,264 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,010,055 - 24,054,777 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,041,848 - 24,054,577 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13523,826,346 - 23,871,192 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03523,876,839 - 23,913,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,310,095 - 25,354,827 (+)NCBIUU_Cfam_GSD_1.0
Trim38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049461,769,006 - 1,779,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366711,841,662 - 1,854,306 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366711,841,722 - 1,853,804 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM38
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,682,652 - 20,704,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1720,682,536 - 20,694,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRIM38
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11746,269,498 - 46,292,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1746,268,289 - 46,292,092 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604425,899,176 - 25,922,157 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Trim38
19 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
sensory system
visual system
17 4 14 13 9 16 1 4 4

Sequence


RefSeq Acc Id: XM_039096440   ⟹   XP_038952368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,774,419 - 41,787,709 (-)NCBI
mRatBN7.21741,351,857 - 41,365,021 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038952368 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_038952368   ⟸   XM_039096440


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596868 AgrOrtholog
BioCyc Gene G2FUF-9388 BioCyc
NCBI Gene 680019 ENTREZGENE
PhenoGen Trim38 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-07 Trim38  tripartite motif containing 38  LOC680019  similar to tripartite motif-containing 38  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680019  similar to tripartite motif-containing 38      Symbol and Name status set to provisional 70820 PROVISIONAL