Bambi (BMP and activin membrane-bound inhibitor) - Rat Genome Database

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Gene: Bambi (BMP and activin membrane-bound inhibitor) Rattus norvegicus
Analyze
Symbol: Bambi
Name: BMP and activin membrane-bound inhibitor
RGD ID: 621831
Description: Predicted to enable frizzled binding activity. Involved in transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis); kinase-deficient TGFbeta superfamily receptor subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,816,438 - 58,821,003 (-)NCBIGRCr8
mRatBN7.21754,121,251 - 54,125,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1757,288,277 - 57,292,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,291,313 - 61,295,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,449,123 - 55,453,381 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,905,419 - 56,909,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,939,068 - 54,943,633 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41762,654,385 - 62,658,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11762,664,912 - 62,669,718 (-)NCBI
Celera1750,102,907 - 50,107,163 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
calciol  (ISO)
cantharidin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoxanthin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia. He Y, etal., Sci Rep. 2016 May 31;6:27051. doi: 10.1038/srep27051.
4. Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells. Loveland KL, etal., Endocrinology 2003 Sep;144(9):4180-6.
5. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Luo X, etal., Diabetes. 2012 Jan;61(1):124-36. doi: 10.2337/db11-0998.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. [Distribution and mRNA Expression of BAMBI in Non-small-cell Lung Cancer.]. Miao S, etal., Zhongguo Fei Ai Za Zhi. 2009 Mar 20;12(3):203-7. doi: 10.3779/j.issn.1009-3419.2009.03.007.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. Togo N, etal., World J Gastroenterol. 2008 Aug 21;14(31):4880-8.
14. BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling. Villar AV, etal., Biochim Biophys Acta. 2013 Feb;1832(2):323-35. doi: 10.1016/j.bbadis.2012.11.007. Epub 2012 Nov 17.
15. BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. Yang Y, etal., Int J Mol Med. 2017 Feb;39(2):423-429. doi: 10.3892/ijmm.2016.2838. Epub 2016 Dec 27.
16. Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-β/Smad pathway in vitro and in vivo. Yu W and Chai H, Oncol Lett. 2017 Oct;14(4):4793-4799. doi: 10.3892/ol.2017.6811. Epub 2017 Aug 24.
17. TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease. Zhang JC, etal., Sci Rep. 2016 Aug 23;6:31911. doi: 10.1038/srep31911.
18. Expression of BAMBI and its combination with Smad7 correlates with tumor invasion and poor prognosis in gastric cancer. Zhang Y, etal., Tumour Biol. 2014 Jul;35(7):7047-56. doi: 10.1007/s13277-014-1962-5. Epub 2014 Apr 23.
Additional References at PubMed
PMID:10942595   PMID:14660579   PMID:15489334   PMID:18838381   PMID:19328798   PMID:22406377   PMID:24155898   PMID:29424488   PMID:31636010  


Genomics

Comparative Map Data
Bambi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,816,438 - 58,821,003 (-)NCBIGRCr8
mRatBN7.21754,121,251 - 54,125,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1757,288,277 - 57,292,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,291,313 - 61,295,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,449,123 - 55,453,381 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,905,419 - 56,909,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,939,068 - 54,943,633 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41762,654,385 - 62,658,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11762,664,912 - 62,669,718 (-)NCBI
Celera1750,102,907 - 50,107,163 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
BAMBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381028,677,521 - 28,682,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1028,677,510 - 28,682,932 (+)EnsemblGRCh38hg38GRCh38
GRCh371028,966,450 - 28,971,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361029,006,430 - 29,011,874 (+)NCBINCBI36Build 36hg18NCBI36
Build 341029,006,458 - 29,011,702NCBI
Celera1028,731,284 - 28,736,727 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1028,685,147 - 28,690,591 (+)NCBIHuRef
CHM1_11028,966,877 - 28,972,320 (+)NCBICHM1_1
T2T-CHM13v2.01028,708,908 - 28,714,318 (+)NCBIT2T-CHM13v2.0
Bambi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39183,507,011 - 3,516,404 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl183,507,923 - 3,516,404 (+)EnsemblGRCm39 Ensembl
GRCm38183,507,011 - 3,516,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl183,507,923 - 3,516,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv37183,507,955 - 3,516,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36183,507,955 - 3,516,402 (+)NCBIMGSCv36mm8
Celera183,558,647 - 3,567,082 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.3NCBI
Bambi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542921,024,374 - 21,025,890 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542921,024,396 - 21,025,890 (+)NCBIChiLan1.0ChiLan1.0
BAMBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2841,354,018 - 41,359,534 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11041,359,721 - 41,364,861 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01028,833,690 - 28,839,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11029,187,857 - 29,193,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1029,187,857 - 29,193,324 (+)Ensemblpanpan1.1panPan2
BAMBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,453,628 - 17,459,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,455,243 - 17,462,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha214,952,595 - 14,958,681 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0215,700,785 - 15,706,918 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl215,700,785 - 15,710,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1215,139,651 - 15,145,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0215,026,954 - 15,033,049 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0215,300,265 - 15,306,392 (-)NCBIUU_Cfam_GSD_1.0
Bambi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093448,547,962 - 8,553,293 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366133,098,159 - 3,103,868 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366133,098,549 - 3,103,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAMBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,053,355 - 40,060,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,053,368 - 40,058,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21044,241,652 - 44,246,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAMBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1928,279,479 - 28,284,825 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl928,279,523 - 28,285,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605134,317,547 - 34,323,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bambi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248051,967,101 - 1,974,898 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248051,967,174 - 1,973,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bambi
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000021801
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 18 10 6 10 6 35 41 11
Low 3 15 39 31 13 31 8 11 68 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000021801   ⟹   ENSRNOP00000021801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)Ensembl
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105136   ⟹   ENSRNOP00000090807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1754,121,255 - 54,124,210 (-)Ensembl
RefSeq Acc Id: NM_139082   ⟹   NP_620782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,816,747 - 58,821,003 (-)NCBI
mRatBN7.21754,121,560 - 54,125,816 (-)NCBI
Rnor_6.01756,905,419 - 56,909,675 (-)NCBI
Rnor_5.01754,939,068 - 54,943,633 (-)NCBI
RGSC_v3.41762,654,385 - 62,658,641 (-)RGD
Celera1750,102,907 - 50,107,163 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096114   ⟹   XP_038952042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,816,438 - 58,820,880 (-)NCBI
mRatBN7.21754,121,251 - 54,125,723 (-)NCBI
RefSeq Acc Id: NP_620782   ⟸   NM_139082
- Peptide Label: precursor
- UniProtKB: Q91XN4 (UniProtKB/Swiss-Prot),   A6K9G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021801   ⟸   ENSRNOT00000021801
RefSeq Acc Id: XP_038952042   ⟸   XM_039096114
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090807   ⟸   ENSRNOT00000105136
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91XN4-F1-model_v2 AlphaFold Q91XN4 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700528
Promoter ID:EPDNEW_R11051
Type:initiation region
Name:Bambi_1
Description:BMP and activin membrane-bound inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01756,909,943 - 56,910,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621831 AgrOrtholog
BioCyc Gene G2FUF-8994 BioCyc
Ensembl Genes ENSRNOG00000016066 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009963 UniProtKB/Swiss-Prot
  ENSRNOG00060015589 UniProtKB/Swiss-Prot
  ENSRNOG00065018422 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021801 ENTREZGENE
  ENSRNOT00000021801.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105136.1 UniProtKB/TrEMBL
  ENSRNOT00055016862 UniProtKB/Swiss-Prot
  ENSRNOT00060026701 UniProtKB/Swiss-Prot
  ENSRNOT00065030920 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100920 IMAGE-MGC_LOAD
InterPro BAMBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAMBI_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAMBI_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91477 IMAGE-MGC_LOAD
NCBI Gene 83837 ENTREZGENE
PANTHER PTHR15505:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIA DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAMBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAMBI_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bambi PhenoGen
PIRSF BAMBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016066 RatGTEx
  ENSRNOG00055009963 RatGTEx
  ENSRNOG00060015589 RatGTEx
  ENSRNOG00065018422 RatGTEx
Superfamily-SCOP SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ABP7 ENTREZGENE, UniProtKB/TrEMBL
  A6K9G6 ENTREZGENE, UniProtKB/TrEMBL
  BAMBI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-31 Bambi  BMP and activin membrane-bound inhibitor  Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in granulosa and thecal cells of adult ovaries, in spermatogonia, spermatocytes, round spermatids, and Sertoli cells of adult testes 632261
gene_homology 89% (nucleic acid) and 95% (amino acid) identical to human homolog 632261