Ucn3 (urocortin 3) - Rat Genome Database

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Pathways
Gene: Ucn3 (urocortin 3) Rattus norvegicus
Analyze
Symbol: Ucn3
Name: urocortin 3
RGD ID: 1562213
Description: Predicted to enable corticotropin-releasing hormone receptor binding activity. Involved in several processes, including cellular response to hypoxia; positive regulation of insulin secretion; and response to corticosterone. Located in axon terminus and varicosity. Orthologous to human UCN3 (urocortin 3); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; INTERACTS WITH acrylamide; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498791; RGD1562213; similar to urocortin III; urocortin 3 (stresscopin); urocortin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,219,611 - 71,225,904 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,215,720 - 71,225,861 (+)EnsemblGRCr8
mRatBN7.21766,309,748 - 66,315,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,309,371 - 66,315,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,783,706 - 69,790,010 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,612,535 - 73,618,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,655,540 - 67,661,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,959,879 - 69,966,532 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,960,160 - 69,966,099 (+)Ensemblrn6Rnor6.0
Rnor_5.01771,663,483 - 71,670,090 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,482,852 - 77,488,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,815,485 - 65,821,104 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. Chanalaris A, etal., J Mol Cell Cardiol. 2003 Oct;35(10):1295-305.
2. Identification of urocortin 3 afferent projection to the ventromedial nucleus of the hypothalamus in rat brain. Chen P, etal., J Comp Neurol. 2011 Jul 1;519(10):2023-42. doi: 10.1002/cne.22620.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
5. Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids. Jamieson PM, etal., Endocrinology. 2006 Oct;147(10):4578-88. Epub 2006 Jun 29.
6. Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. Li C, etal., J Neurosci 2002 Feb 1;22(3):991-1001.
7. Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Li C, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4206-11. Epub 2007 Feb 27.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress. Teitelbaum AA, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G452-9. Epub 2008 Jul 17.
Additional References at PubMed
PMID:11329063   PMID:11416224   PMID:17019404   PMID:17218420   PMID:19395554   PMID:19952342   PMID:22227020   PMID:22651925   PMID:22774996   PMID:24462512   PMID:25122003   PMID:25779038  
PMID:31415798   PMID:35325259  


Genomics

Comparative Map Data
Ucn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,219,611 - 71,225,904 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,215,720 - 71,225,861 (+)EnsemblGRCr8
mRatBN7.21766,309,748 - 66,315,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,309,371 - 66,315,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,783,706 - 69,790,010 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,612,535 - 73,618,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,655,540 - 67,661,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,959,879 - 69,966,532 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,960,160 - 69,966,099 (+)Ensemblrn6Rnor6.0
Rnor_5.01771,663,483 - 71,670,090 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,482,852 - 77,488,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,815,485 - 65,821,104 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
UCN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,364,966 - 5,374,692 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,364,966 - 5,374,692 (+)Ensemblhg38GRCh38
GRCh37105,406,929 - 5,416,655 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,396,976 - 5,406,169 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34105,396,975 - 5,406,169NCBI
Celera105,339,562 - 5,339,918 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,338,811 - 5,339,167 (+)NCBIHuRef
CHM1_1105,406,973 - 5,416,168 (+)NCBICHM1_1
T2T-CHM13v2.0105,366,734 - 5,377,963 (+)NCBIT2T-CHM13v2.0
Ucn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39133,990,688 - 3,995,349 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl133,990,688 - 3,995,349 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38133,940,688 - 3,945,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl133,940,688 - 3,945,349 (-)Ensemblmm10GRCm38
MGSCv37133,939,934 - 3,944,595 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36133,940,402 - 3,940,896 (-)NCBIMGSCv36mm8
Celera133,927,567 - 3,932,226 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.2NCBI
Ucn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955463218,456 - 218,959 (+)NCBIChiLan1.0ChiLan1.0
UCN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,930,638 - 17,931,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,935,959 - 17,936,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,410,501 - 5,419,650 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,398,032 - 5,406,168 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,405,683 - 5,406,168 (+)EnsemblpanPan2panpan1.1
UCN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,541,316 - 30,547,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,541,779 - 30,542,282 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha227,570,906 - 27,577,392 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0230,921,836 - 30,928,322 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,922,266 - 30,922,769 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,017,884 - 28,024,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,855,014 - 28,861,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,572,632 - 29,579,118 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
UCN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11065,491,231 - 65,495,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,585,818 - 71,590,322 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,491,134 - 5,500,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl95,498,945 - 5,499,430 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605110,742,618 - 10,751,305 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ucn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624796130,924 - 131,886 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ucn3
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000023887
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 7 78 25 26 9 8 9 6 68 25 66 26 37 17 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000023887   ⟹   ENSRNOP00000023887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,215,720 - 71,225,861 (+)Ensembl
mRatBN7.2 Ensembl1766,309,371 - 66,315,990 (+)Ensembl
Rnor_6.0 Ensembl1769,960,160 - 69,966,099 (+)Ensembl
RefSeq Acc Id: NM_001080208   ⟹   NP_001073677
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,219,656 - 71,225,904 (+)NCBI
mRatBN7.21766,309,748 - 66,315,996 (+)NCBI
Rnor_6.01769,960,160 - 69,966,111 (+)NCBI
Rnor_5.01771,663,483 - 71,670,090 (+)NCBI
RGSC_v3.41777,482,852 - 77,488,471 (+)RGD
Celera1765,815,485 - 65,821,104 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276701   ⟹   XP_063132771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,219,611 - 71,225,904 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001073677 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM45865 (Get FASTA)   NCBI Sequence Viewer  
  EDL78577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023887
  ENSRNOP00000023887.5
RefSeq Acc Id: NP_001073677   ⟸   NM_001080208
- Peptide Label: precursor
- UniProtKB: A1YKY5 (UniProtKB/TrEMBL),   F7FC99 (UniProtKB/TrEMBL),   A0A9K3Y7D4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023887   ⟸   ENSRNOT00000023887
RefSeq Acc Id: XP_063132771   ⟸   XM_063276701
- Peptide Label: isoform X1
- UniProtKB: A0A9K3Y7D4 (UniProtKB/TrEMBL),   A1YKY5 (UniProtKB/TrEMBL),   F7FC99 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FC99-F1-model_v2 AlphaFold F7FC99 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562213 AgrOrtholog
BioCyc Gene G2FUF-8825 BioCyc
Ensembl Genes ENSRNOG00000017759 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023887 ENTREZGENE
  ENSRNOT00000023887.6 UniProtKB/TrEMBL
InterPro CRF UniProtKB/TrEMBL
  Urocortin_II/III UniProtKB/TrEMBL
KEGG Report rno:498791 UniProtKB/TrEMBL
NCBI Gene 498791 ENTREZGENE
PANTHER PTHR17575 UniProtKB/TrEMBL
  UROCORTIN-3 UniProtKB/TrEMBL
Pfam CRF UniProtKB/TrEMBL
PhenoGen Ucn3 PhenoGen
RatGTEx ENSRNOG00000017759 RatGTEx
UniProt A0A9K3Y7D4 ENTREZGENE, UniProtKB/TrEMBL
  A1YKY5 ENTREZGENE, UniProtKB/TrEMBL
  F7FC99 ENTREZGENE
UniProt Secondary F7FC99 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-24 Ucn3  urocortin 3  Ucn3  urocortin 3 (stresscopin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Ucn3  urocortin 3 (stresscopin)  Ucn3  urocortin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Ucn3  urocortin 3  RGD1562213_predicted  similar to urocortin III (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562213_predicted  similar to urocortin III (predicted)  LOC498791  similar to urocortin III  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498791  similar to urocortin III      Symbol and Name status set to provisional 70820 PROVISIONAL