Calml5 (calmodulin-like 5) - Rat Genome Database

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Gene: Calml5 (calmodulin-like 5) Rattus norvegicus
Analyze
Symbol: Calml5
Name: calmodulin-like 5
RGD ID: 1310047
Description: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Orthologous to human CALML5 (calmodulin like 5); PARTICIPATES IN Alzheimer's disease pathway; calcium/calcium-mediated signaling pathway; glioma pathway; INTERACTS WITH acrylamide; bisphenol A; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Calm4; calmodulin 4; calmodulin-4; calmodulin-like protein 5; LOC364774
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,304,326 - 71,305,245 (-)NCBIGRCr8
mRatBN7.21766,394,433 - 66,395,352 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1769,875,510 - 69,876,429 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,704,319 - 73,705,238 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,747,336 - 67,748,255 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,044,956 - 70,045,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,748,514 - 71,749,406 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,567,314 - 77,571,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,574,768 - 77,578,923 (-)NCBI
Celera1765,900,164 - 65,901,094 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Nättinen J, etal., Ocul Surf. 2018 Jan;16(1):84-92. doi: 10.1016/j.jtos.2017.09.003. Epub 2017 Sep 14.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains. Solomon B, etal., Brain Res Bull. 2001 May 15;55(2):253-6.
Additional References at PubMed
PMID:12970338   PMID:20439489   PMID:21873635   PMID:23376485  


Genomics

Comparative Map Data
Calml5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,304,326 - 71,305,245 (-)NCBIGRCr8
mRatBN7.21766,394,433 - 66,395,352 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1769,875,510 - 69,876,429 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,704,319 - 73,705,238 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,747,336 - 67,748,255 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,044,956 - 70,045,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,748,514 - 71,749,406 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,567,314 - 77,571,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,574,768 - 77,578,923 (-)NCBI
Celera1765,900,164 - 65,901,094 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
CALML5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,498,697 - 5,499,570 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,498,697 - 5,499,570 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,540,660 - 5,541,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,530,660 - 5,531,510 (-)NCBINCBI36Build 36hg18NCBI36
Build 34105,530,660 - 5,531,510NCBI
Celera105,471,713 - 5,472,588 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,470,562 - 5,471,437 (-)NCBIHuRef
CHM1_1105,540,560 - 5,541,435 (-)NCBICHM1_1
T2T-CHM13v2.0105,501,934 - 5,502,807 (-)NCBIT2T-CHM13v2.0
Calm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39133,887,757 - 3,888,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl133,887,757 - 3,888,673 (+)EnsemblGRCm39 Ensembl
GRCm38133,837,757 - 3,838,671 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl133,837,757 - 3,838,673 (+)EnsemblGRCm38mm10GRCm38
MGSCv37133,837,003 - 3,837,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36133,837,003 - 3,837,917 (+)NCBIMGSCv36mm8
MGSCv36133,642,313 - 3,643,227 (+)NCBIMGSCv36mm8
Celera133,820,901 - 3,821,772 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.15NCBI
CALML5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,051,489 - 18,052,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,056,812 - 18,057,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,539,954 - 5,540,829 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,525,980 - 5,526,849 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,526,283 - 5,526,723 (-)Ensemblpanpan1.1panPan2
CALML5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,431,088 - 30,431,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,429,338 - 30,431,948 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,460,882 - 27,461,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0230,812,107 - 30,812,964 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1227,908,372 - 27,909,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,745,562 - 28,746,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,463,256 - 29,464,113 (+)NCBIUU_Cfam_GSD_1.0
Calml5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,834,100 - 32,835,035 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364848,999,323 - 9,000,224 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALML5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,406,633 - 65,407,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,405,928 - 65,407,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,775,723 - 71,778,067 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALML5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,609,208 - 5,610,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl95,609,912 - 5,610,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605110,865,499 - 10,866,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Calml5
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
RH134762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,394,635 - 66,394,823 (+)MAPPERmRatBN7.2
Rnor_6.01770,045,159 - 70,045,346NCBIRnor6.0
Rnor_5.01771,748,717 - 71,748,904UniSTSRnor5.0
RGSC_v3.41777,567,517 - 77,567,704UniSTSRGSC3.4
Celera1765,900,367 - 65,900,554UniSTS
RH 3.4 Map17635.5UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_001400752   ⟹   NP_001387681
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,304,326 - 71,305,245 (-)NCBI
mRatBN7.21766,394,433 - 66,395,352 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387681 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001387681   ⟸   NM_001400752
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310047 AgrOrtholog
BioCyc Gene G2FUF-8820 BioCyc
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro Calmodulin_Centrin_Ca-Bind UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene 364774 ENTREZGENE
PANTHER CALCIUM BINDING PROTEIN UniProtKB/TrEMBL
  CALMODULIN-LIKE PROTEIN 5 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PhenoGen Calml5 PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL
UniProt A6JLQ4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Calml5  calmodulin-like 5  Calm4  calmodulin 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Calm4  calmodulin 4   Calm4_predicted  calmodulin 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Calm4_predicted  calmodulin 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED