Hist1h2an (histone cluster 1, H2an) - Rat Genome Database

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Gene: Hist1h2an (histone cluster 1, H2an) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hist1h2an (Ensembl: hist1h2ail2)
Name: histone cluster 1, H2an (Ensembl:histone cluster 1, H2ai-like2)
RGD ID: 1309078
Description: Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in heterochromatin organization. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AC4 (H2A clustered histone 4) and H2AC8 (H2A clustered histone 8); PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone 1, H2an; LOC306970
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,961,533 - 41,963,297 (+)NCBIGRCr8
mRatBN7.21741,534,653 - 41,535,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,534,691 - 41,539,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1741,615,299 - 41,615,905 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01743,219,365 - 43,219,971 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01741,493,811 - 41,494,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01743,779,174 - 43,779,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,758,460 - 44,758,852 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,779,174 - 43,779,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,794,130 - 44,794,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,520,537 - 44,520,929 (+)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.11750,355,603 - 50,387,125 (+)NCBI
Celera1741,165,567 - 41,166,173 (+)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleosome  (IBA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Hist1h2an
2 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 12 1 16 1 1 1 1 2 8 7 1
Low 3 29 35 30 3 30 7 8 62 27 31 4 7
Below cutoff 12 10 10 10 2 11 5 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077571   ⟹   ENSRNOP00000073576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1744,794,130 - 44,794,522 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077985   ⟹   ENSRNOP00000073632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1744,520,537 - 44,520,929 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089436   ⟹   ENSRNOP00000071032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1744,758,460 - 44,758,852 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1743,779,174 - 43,779,775 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104913   ⟹   ENSRNOP00000094790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1741,534,691 - 41,539,869 (+)Ensembl
RefSeq Acc Id: NM_001107354   ⟹   NP_001100824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,962,691 - 41,963,297 (+)NCBI
mRatBN7.21741,534,653 - 41,535,259 (+)NCBI
Rnor_6.01743,779,174 - 43,779,775 (+)NCBI
Celera1741,165,567 - 41,166,173 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276447   ⟹   XP_063132517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,961,533 - 41,963,258 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132517 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86587 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080682.1
  ENSRNOP00000094790
  ENSRNOP00000094790.1
Reference Protein Sequences
RefSeq Acc Id: NP_001100824   ⟸   NM_001107354
- UniProtKB: Q64598 (UniProtKB/Swiss-Prot),   G3V9C0 (UniProtKB/TrEMBL),   A6KLN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073576   ⟸   ENSRNOT00000077571
RefSeq Acc Id: ENSRNOP00000071032   ⟸   ENSRNOT00000089436
RefSeq Acc Id: ENSRNOP00000073632   ⟸   ENSRNOT00000077985
RefSeq Acc Id: ENSRNOP00000094790   ⟸   ENSRNOT00000104913
RefSeq Acc Id: XP_063132517   ⟸   XM_063276447
- Peptide Label: isoform X1
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9C0-F1-model_v2 AlphaFold G3V9C0 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309078 AgrOrtholog
BioCyc Gene G2FUF-9365 BioCyc
Ensembl Genes ENSRNOG00000056411 Ensembl
  ENSRNOG00000057700 Ensembl
  ENSRNOG00000058437 Ensembl
  ENSRNOG00000059748 Ensembl
  ENSRNOG00000067434 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000070462 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095023.1 UniProtKB/TrEMBL
  ENSRNOT00000104913 ENTREZGENE
  ENSRNOT00000104913.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_core_D UniProtKB/TrEMBL
  Histone_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360754 UniProtKB/TrEMBL
  rno:306970 UniProtKB/TrEMBL
  rno:502129 UniProtKB/TrEMBL
NCBI Gene 306970 ENTREZGENE
PANTHER HISTONE H2A UniProtKB/Swiss-Prot
  HISTONE H2A TYPE 1-B/E UniProtKB/Swiss-Prot
  HISTONE H2A TYPE 1-D UniProtKB/TrEMBL
  PTHR23430 UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hist1h2an PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056411 RatGTEx
  ENSRNOG00000057700 RatGTEx
  ENSRNOG00000058437 RatGTEx
  ENSRNOG00000059748 RatGTEx
  ENSRNOG00000067434 RatGTEx
  ENSRNOG00000070462 RatGTEx
SMART H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KLN9 ENTREZGENE, UniProtKB/TrEMBL
  G3V9C0 ENTREZGENE, UniProtKB/TrEMBL
  H2A1F_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hist1h2an  histone cluster 1, H2an   Hist1h2an_predicted  histone cluster 1, H2an (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-07 Hist1h2an_predicted  histone cluster 1, H2an (predicted)    histone 1, H2an (predicted)  Name updated 1299863 APPROVED
2005-01-12 Hist1h2an_predicted  histone 1, H2an (predicted)      Symbol and Name status set to approved 70820 APPROVED