Pfkp (phosphofructokinase, platelet) - Rat Genome Database

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Gene: Pfkp (phosphofructokinase, platelet) Rattus norvegicus
Analyze
Symbol: Pfkp
Name: phosphofructokinase, platelet
RGD ID: 61893
Description: Enables 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Orthologous to human PFKP (phosphofructokinase, platelet); PARTICIPATES IN fructose and mannose metabolic pathway; galactose metabolic pathway; gluconeogenesis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-1-kinase, C-type; 6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; MGC105718; PFK-C; PFK-P; pfkc; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphofructokinase C-type subunit; phosphohexokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81768,639,749 - 68,704,055 (+)NCBIGRCr8
mRatBN7.21763,729,743 - 63,794,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1767,232,016 - 67,296,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,060,799 - 71,125,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,083,081 - 65,147,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01768,510,765 - 68,574,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1768,511,064 - 68,559,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01770,227,547 - 70,290,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41774,760,912 - 74,823,046 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11774,771,768 - 74,833,862 (+)NCBI
Celera1763,327,855 - 63,392,034 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
caffeine  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
haloperidol  (EXP,ISO)
hydrogen sulfide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mithramycin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
puerarin  (EXP)
Pyridostigmine bromide  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
razoxane  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
scoparone  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
6-phosphofructokinase complex  (IBA)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structure, distribution, and functional expression of the phosphofructokinase C isozyme. Gekakis N, etal., J Biol Chem 1994 Feb 4;269(5):3348-55.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Isoenzymes of phosphofructokinase in the rat. Demonstration of the three non-identical subunits by biochemical, immunochemical and kinetic studies. Vora S, etal., Biochem J. 1985 Jul 15;229(2):333-41.
11. Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization. Yamashita M, etal., Endocrinology 2002 Nov;143(11):4464-76.
Additional References at PubMed
PMID:2521854   PMID:2960695   PMID:6444721   PMID:6451249   PMID:7825568   PMID:12477932   PMID:14760703   PMID:15489334   PMID:19946888   PMID:20439489   PMID:20458337   PMID:21630459  
PMID:22871113   PMID:23209302   PMID:23979707   PMID:25468996   PMID:25985179   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Pfkp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81768,639,749 - 68,704,055 (+)NCBIGRCr8
mRatBN7.21763,729,743 - 63,794,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1767,232,016 - 67,296,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,060,799 - 71,125,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,083,081 - 65,147,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01768,510,765 - 68,574,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1768,511,064 - 68,559,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01770,227,547 - 70,290,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41774,760,912 - 74,823,046 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11774,771,768 - 74,833,862 (+)NCBI
Celera1763,327,855 - 63,392,034 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
PFKP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,067,548 - 3,136,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,066,333 - 3,137,718 (+)EnsemblGRCh38hg38GRCh38
GRCh37103,109,740 - 3,178,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,099,752 - 3,168,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 34103,099,751 - 3,168,995NCBI
Celera103,056,125 - 3,124,845 (+)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,045,950 - 3,114,052 (+)NCBIHuRef
CHM1_1103,109,390 - 3,178,958 (+)NCBICHM1_1
T2T-CHM13v2.0103,068,649 - 3,138,082 (+)NCBIT2T-CHM13v2.0
Pfkp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,629,910 - 6,699,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,629,804 - 6,698,813 (-)EnsemblGRCm39 Ensembl
GRCm38136,579,874 - 6,649,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,579,768 - 6,648,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv37136,579,120 - 6,647,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,579,120 - 6,647,970 (-)NCBIMGSCv36mm8
Celera136,529,169 - 6,596,776 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.25NCBI
Pfkp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542128,043,271 - 28,086,796 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542128,042,973 - 28,098,358 (-)NCBIChiLan1.0ChiLan1.0
PFKP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2815,557,973 - 15,629,863 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11015,563,326 - 15,635,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,062,844 - 3,134,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,080,248 - 3,148,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,080,242 - 3,244,790 (+)Ensemblpanpan1.1panPan2
PFKP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1232,220,876 - 32,254,354 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl232,220,878 - 32,260,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,249,439 - 29,293,199 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,603,570 - 32,647,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,603,572 - 32,647,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,690,270 - 29,734,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0230,527,797 - 30,571,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,255,597 - 31,299,277 (-)NCBIUU_Cfam_GSD_1.0
Pfkp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,940,588 - 34,996,015 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648411,103,142 - 11,161,344 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648411,105,814 - 11,161,238 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1067,022,655 - 67,082,449 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11067,022,652 - 67,082,336 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21073,581,212 - 73,608,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,130,701 - 3,191,590 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,130,566 - 3,191,576 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660518,281,360 - 8,342,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247757,324,662 - 7,390,271 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247757,325,032 - 7,390,200 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pfkp
587 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:129
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000023252
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
RH127612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21763,793,692 - 63,793,903 (-)MAPPERmRatBN7.2
Rnor_6.01768,510,879 - 68,511,089NCBIRnor6.0
Rnor_5.01770,227,661 - 70,227,871UniSTSRnor5.0
RGSC_v3.41774,822,722 - 74,822,932UniSTSRGSC3.4
Celera1763,391,710 - 63,391,920UniSTS
Cytogenetic Map17q12.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023252   ⟹   ENSRNOP00000023252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)Ensembl
Rnor_6.0 Ensembl1768,511,064 - 68,559,471 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094864   ⟹   ENSRNOP00000084974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108657   ⟹   ENSRNOP00000097741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)Ensembl
RefSeq Acc Id: NM_206847   ⟹   NP_996729
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81768,639,813 - 68,704,055 (+)NCBI
mRatBN7.21763,729,776 - 63,794,026 (+)NCBI
Rnor_6.01768,510,765 - 68,574,387 (-)NCBI
Rnor_5.01770,227,547 - 70,290,384 (-)NCBI
RGSC_v3.41774,760,912 - 74,823,046 (+)RGD
Celera1763,327,855 - 63,392,034 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096037   ⟹   XP_038951965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81768,639,749 - 68,704,050 (+)NCBI
mRatBN7.21763,729,747 - 63,794,021 (+)NCBI
RefSeq Acc Id: XM_063276718   ⟹   XP_063132788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81768,639,749 - 68,704,050 (+)NCBI
RefSeq Acc Id: NP_996729   ⟸   NM_206847
- UniProtKB: Q5HZX8 (UniProtKB/Swiss-Prot),   P47860 (UniProtKB/Swiss-Prot),   C7C5T2 (UniProtKB/TrEMBL),   A0A0A0MXY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023252   ⟸   ENSRNOT00000023252
RefSeq Acc Id: XP_038951965   ⟸   XM_039096037
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B663 (UniProtKB/TrEMBL),   A0A8I5ZYA2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097741   ⟸   ENSRNOT00000108657
Ensembl Acc Id: ENSRNOP00000084974   ⟸   ENSRNOT00000094864
RefSeq Acc Id: XP_063132788   ⟸   XM_063276718
- Peptide Label: isoform X2
Protein Domains
Phosphofructokinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47860-F1-model_v2 AlphaFold P47860 1-788 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61893 AgrOrtholog
BioCyc Gene G2FUF-8868 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
Ensembl Genes ENSRNOG00000017163 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006544 UniProtKB/Swiss-Prot
  ENSRNOG00060015533 UniProtKB/Swiss-Prot
  ENSRNOG00065003704 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023252 UniProtKB/TrEMBL
  ENSRNOT00000023252.8 UniProtKB/Swiss-Prot
  ENSRNOT00000094864.1 UniProtKB/TrEMBL
  ENSRNOT00000108657.1 UniProtKB/TrEMBL
  ENSRNOT00055010648 UniProtKB/Swiss-Prot
  ENSRNOT00060026666 UniProtKB/Swiss-Prot
  ENSRNOT00065005398 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312293 IMAGE-MGC_LOAD
InterPro 6-Pfructokinase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_PFK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PFK_vert-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphofructokinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphofructokinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105718 IMAGE-MGC_LOAD
NCBI Gene 60416 ENTREZGENE
PANTHER ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PFK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkp PhenoGen
PIRSF ATP_PFK_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHFRCTKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017163 RatGTEx
  ENSRNOG00055006544 RatGTEx
  ENSRNOG00060015533 RatGTEx
  ENSRNOG00065003704 RatGTEx
Superfamily-SCOP SSF53784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B663 ENTREZGENE, UniProtKB/TrEMBL
  A6JLM4_RAT UniProtKB/TrEMBL
  A6JLM5_RAT UniProtKB/TrEMBL
  A6JLM6_RAT UniProtKB/TrEMBL
  C7C5T2 ENTREZGENE, UniProtKB/TrEMBL
  P47860 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5HZX8 ENTREZGENE
UniProt Secondary Q5HZX8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pfkp  phosphofructokinase, platelet    phosphofructokinase, platelet   Name updated 1299863 APPROVED
2002-06-10 Pfkp  phosphofructokinase, platelet       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 61692
gene_expression preferentially expressed in oxytocin-expressing magnocellular neurons (MCNs) 628363
gene_expression expressed mainly in the brain and in neuroendocrine tissues 628363
gene_function catalyzes the ATP-dependent conversion of fructose 6-phosphate to fructose 1, 6-bisphosphate 628363
gene_protein 765 amino acids 61692