PFKP (phosphofructokinase, platelet) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PFKP (phosphofructokinase, platelet) Sus scrofa
Analyze
Symbol: PFKP
Name: phosphofructokinase, platelet
RGD ID: 14287395
Description: ENCODES a protein that exhibits 6-phosphofructokinase activity (ortholog); ATP binding (ortholog); fructose-6-phosphate binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); fructose 1,6-bisphosphate metabolic process (ortholog); fructose 6-phosphate metabolic process (ortholog); PARTICIPATES IN glycolysis pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); schizophrenia (ortholog); FOUND IN 6-phosphofructokinase complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type; PFKP_tv1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1067,022,655 - 67,082,449 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11067,022,652 - 67,082,336 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21073,581,212 - 73,608,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
6-phosphofructokinase complex  (IBA,IEA)
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PFKP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1067,022,655 - 67,082,449 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11067,022,652 - 67,082,336 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21073,581,212 - 73,608,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,067,548 - 3,136,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,066,333 - 3,137,718 (+)EnsemblGRCh38hg38GRCh38
GRCh37103,109,740 - 3,178,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,099,752 - 3,168,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 34103,099,751 - 3,168,995NCBI
Celera103,056,125 - 3,124,845 (+)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,045,950 - 3,114,052 (+)NCBIHuRef
CHM1_1103,109,390 - 3,178,958 (+)NCBICHM1_1
T2T-CHM13v2.0103,068,649 - 3,138,082 (+)NCBIT2T-CHM13v2.0
Pfkp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,629,910 - 6,699,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,629,804 - 6,698,813 (-)EnsemblGRCm39 Ensembl
GRCm38136,579,874 - 6,649,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,579,768 - 6,648,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv37136,579,120 - 6,647,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,579,120 - 6,647,970 (-)NCBIMGSCv36mm8
Celera136,529,169 - 6,596,776 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.25NCBI
Pfkp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81768,639,749 - 68,704,055 (+)NCBIGRCr8
mRatBN7.21763,729,743 - 63,794,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1763,729,780 - 63,794,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1767,232,016 - 67,296,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,060,799 - 71,125,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,083,081 - 65,147,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01768,510,765 - 68,574,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1768,511,064 - 68,559,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01770,227,547 - 70,290,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41774,760,912 - 74,823,046 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11774,771,768 - 74,833,862 (+)NCBI
Celera1763,327,855 - 63,392,034 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
Pfkp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542128,043,271 - 28,086,796 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542128,042,973 - 28,098,358 (-)NCBIChiLan1.0ChiLan1.0
PFKP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2815,557,973 - 15,629,863 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11015,563,326 - 15,635,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,062,844 - 3,134,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,080,248 - 3,148,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,080,242 - 3,244,790 (+)Ensemblpanpan1.1panPan2
PFKP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1232,220,876 - 32,254,354 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl232,220,878 - 32,260,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,249,439 - 29,293,199 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,603,570 - 32,647,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,603,572 - 32,647,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,690,270 - 29,734,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0230,527,797 - 30,571,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,255,597 - 31,299,277 (-)NCBIUU_Cfam_GSD_1.0
Pfkp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,940,588 - 34,996,015 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648411,103,142 - 11,161,344 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648411,105,814 - 11,161,238 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,130,701 - 3,191,590 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,130,566 - 3,191,576 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660518,281,360 - 8,342,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247757,324,662 - 7,390,271 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247757,325,032 - 7,390,200 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PFKP
2669 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 1 11 1
Low 5 4 1 4 2 12 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012220   ⟹   ENSSSCP00000011907
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1067,022,656 - 67,082,449 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000027374   ⟹   ENSSSCP00000024482
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1067,022,655 - 67,082,263 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000047313   ⟹   ENSSSCP00000041243
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1067,022,656 - 67,082,449 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082879   ⟹   ENSSSCP00000072258
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1067,022,656 - 67,082,237 (-)Ensembl
RefSeq Acc Id: XM_021065066   ⟹   XP_020920725
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11067,022,652 - 67,082,336 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020920725   ⟸   XM_021065066
- UniProtKB: A0A5K1V863 (UniProtKB/TrEMBL),   A0A8D1YDH4 (UniProtKB/TrEMBL),   A0A8D1QP33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011907   ⟸   ENSSSCT00000012220
RefSeq Acc Id: ENSSSCP00000024482   ⟸   ENSSSCT00000027374
RefSeq Acc Id: ENSSSCP00000041243   ⟸   ENSSSCT00000047313
RefSeq Acc Id: ENSSSCP00000072258   ⟸   ENSSSCT00000082879
Protein Domains
Phosphofructokinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025020841 UniProtKB/TrEMBL
  ENSSSCG00030072678 UniProtKB/TrEMBL
  ENSSSCG00040002605 UniProtKB/TrEMBL
  ENSSSCG00045030544 UniProtKB/TrEMBL
  ENSSSCG00050003209 UniProtKB/TrEMBL
  ENSSSCG00055015197 UniProtKB/TrEMBL
  ENSSSCG00060018869 UniProtKB/TrEMBL
  ENSSSCG00065032750 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012220 ENTREZGENE
  ENSSSCT00000012220.5 UniProtKB/TrEMBL
  ENSSSCT00000027374.4 UniProtKB/TrEMBL
  ENSSSCT00000047313.3 UniProtKB/TrEMBL
  ENSSSCT00000082879.2 UniProtKB/TrEMBL
  ENSSSCT00025028334.1 UniProtKB/TrEMBL
  ENSSSCT00025028365.1 UniProtKB/TrEMBL
  ENSSSCT00025028386.1 UniProtKB/TrEMBL
  ENSSSCT00025028427.1 UniProtKB/TrEMBL
  ENSSSCT00030101802.1 UniProtKB/TrEMBL
  ENSSSCT00030101825.1 UniProtKB/TrEMBL
  ENSSSCT00030101856.1 UniProtKB/TrEMBL
  ENSSSCT00030101898.1 UniProtKB/TrEMBL
  ENSSSCT00030101938.1 UniProtKB/TrEMBL
  ENSSSCT00040003203.1 UniProtKB/TrEMBL
  ENSSSCT00040003230.1 UniProtKB/TrEMBL
  ENSSSCT00045052966.1 UniProtKB/TrEMBL
  ENSSSCT00045053610.1 UniProtKB/TrEMBL
  ENSSSCT00045053806.1 UniProtKB/TrEMBL
  ENSSSCT00050004249.1 UniProtKB/TrEMBL
  ENSSSCT00050004272.1 UniProtKB/TrEMBL
  ENSSSCT00055029999.1 UniProtKB/TrEMBL
  ENSSSCT00055030131.1 UniProtKB/TrEMBL
  ENSSSCT00055030221.1 UniProtKB/TrEMBL
  ENSSSCT00055030328.1 UniProtKB/TrEMBL
  ENSSSCT00055030486.1 UniProtKB/TrEMBL
  ENSSSCT00060025378.1 UniProtKB/TrEMBL
  ENSSSCT00060025384.1 UniProtKB/TrEMBL
  ENSSSCT00060025388.1 UniProtKB/TrEMBL
  ENSSSCT00060025394.1 UniProtKB/TrEMBL
  ENSSSCT00065044472.1 UniProtKB/TrEMBL
  ENSSSCT00065044478.1 UniProtKB/TrEMBL
  ENSSSCT00065044487.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.450 UniProtKB/TrEMBL
  3.40.50.460 UniProtKB/TrEMBL
InterPro 6-Pfructokinase_euk UniProtKB/TrEMBL
  ATP_PFK UniProtKB/TrEMBL
  PFK_vert-type UniProtKB/TrEMBL
  Phosphofructokinase_CS UniProtKB/TrEMBL
  Phosphofructokinase_dom UniProtKB/TrEMBL
  PKF_sf UniProtKB/TrEMBL
NCBI Gene PFKP ENTREZGENE
PANTHER ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE UniProtKB/TrEMBL
  PHOSPHOFRUCTOKINASE UniProtKB/TrEMBL
Pfam PFK UniProtKB/TrEMBL
PIRSF ATP_PFK_euk UniProtKB/TrEMBL
PRINTS PHFRCTKINASE UniProtKB/TrEMBL
PROSITE PHOSPHOFRUCTOKINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53784 UniProtKB/TrEMBL
UniProt A0A287AB45_PIG UniProtKB/TrEMBL
  A0A5G2RD49_PIG UniProtKB/TrEMBL
  A0A5K1V863 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0R7U5_PIG UniProtKB/TrEMBL
  A0A8D0YAG4_PIG UniProtKB/TrEMBL
  A0A8D0YC73_PIG UniProtKB/TrEMBL
  A0A8D1JQE5_PIG UniProtKB/TrEMBL
  A0A8D1QP33 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QST3_PIG UniProtKB/TrEMBL
  A0A8D1QX30_PIG UniProtKB/TrEMBL
  A0A8D1QY05_PIG UniProtKB/TrEMBL
  A0A8D1U3F7_PIG UniProtKB/TrEMBL
  A0A8D1YDH4 ENTREZGENE, UniProtKB/TrEMBL
  F1RX49_PIG UniProtKB/TrEMBL
  I3LK68_PIG UniProtKB/TrEMBL
UniProt Secondary K9J4R6 UniProtKB/TrEMBL
VGNC ID VGNC:96481 ENTREZGENE