RGD Reference Report - Response of rat cerebral glycolytic enzymes to hyperammonemic states. - Rat Genome Database

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Response of rat cerebral glycolytic enzymes to hyperammonemic states.

Authors: Ratnakumari, L  Murthy, CR 
Citation: Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
RGD ID: 2302804
Pubmed: (View Article at PubMed) PMID:8255543

Activity levels of enzymes of glycolytic pathway viz., hexokinase (EC.2.7.1.1), phosphofructokinase (EC.2.7.1.11), aldolase (EC.4.1.2.13), glyceraldehyde-3-phosphate dehydrogenase (EC.1.2.1.12), enolase (EC.4.2.1.11), pyruvate kinase (EC.2.7.1.40) and lactate dehydrogenase (EC.1.1.1.27) were estimated in cerebral cortex, cerebellum and brainstem of the rats treated with subacute and acute doses of ammonium acetate and compared with those of control animals. In general, the activities of all the enzymes except for hexokinase and lactate dehydrogenase, were elevated in all the three regions of the brain. The results suggests an enhanced rate of glycolysis in brain in hyperammonemic states and strengthens the role of ammonium ion in stimulating certain enzymes of the glycolytic pathway.

Annotation

Gene Ontology Annotations    

Biological Process

Molecular Function

Molecular Pathway Annotations    
glycolysis pathway  (IDA,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Aldob  (aldolase, fructose-bisphosphate B)
Eno2  (enolase 2)
Gapdh  (glyceraldehyde-3-phosphate dehydrogenase)
Hk1  (hexokinase 1)
Pfkp  (phosphofructokinase, platelet)
Pkm  (pyruvate kinase M1/2)

Genes (Mus musculus)
Aldob  (aldolase B, fructose-bisphosphate)
Eno2  (enolase 2, gamma neuronal)
Gapdh  (glyceraldehyde-3-phosphate dehydrogenase)
Hk1  (hexokinase 1)
Pfkp  (phosphofructokinase, platelet)
Pkm  (pyruvate kinase, muscle)

Genes (Homo sapiens)
ALDOB  (aldolase, fructose-bisphosphate B)
ENO2  (enolase 2)
GAPDH  (glyceraldehyde-3-phosphate dehydrogenase)
HK1  (hexokinase 1)
PFKP  (phosphofructokinase, platelet)
PKM  (pyruvate kinase M1/2)


Additional Information