![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FZD8 mRNA] | CTD | PMID:31150632 | 1,2-dichloroethane | decreases expression | ISO | RGD:1558526 | 6480464 | ethylene dichloride results in decreased expression of FZD8 mRNA | CTD | PMID:28189721, PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1558526 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of FZD8 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of FZD8 mRNA | CTD | PMID:25380136 | 17beta-estradiol | decreases expression | ISO | RGD:1350514 | 6480464 | Estradiol results in decreased expression of FZD8 mRNA | CTD | PMID:21185374 | 17beta-estradiol | multiple interactions | ISO | RGD:1350514 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of FZD8 mRNA | CTD | PMID:30165855 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | RGD:1350514 | 6480464 | 2 more ... | CTD | PMID:31326446 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1558526 | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FZD8 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558526 | 6480464 | Tetrachlorodibenzodioxin affects the expression of FZD8 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1558526 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FZD8 mRNA | CTD | PMID:26290441, PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FZD8 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558526 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FZD8 mRNA | CTD | PMID:15667827 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | RGD:1350514 | 6480464 | tetrabromobisphenol A results in increased expression of FZD8 mRNA | CTD | PMID:31326446 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1558526 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of FZD8 mRNA | CTD | PMID:19285098 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of FZD8 mRNA | CTD | PMID:25380136 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RGD:1558526 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased methylation of FZD8 exon | CTD | PMID:33297965 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1558526 | 6480464 | Decitabine results in increased expression of FZD8 mRNA | CTD | PMID:27915011 | acetaldehyde | affects expression | ISO | RGD:1558526 | 6480464 | Acetaldehyde affects the expression of FZD8 mRNA | CTD | PMID:22634333 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of FZD8 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases methylation | ISO | RGD:1350514 | 6480464 | Aflatoxin B1 results in increased methylation of FZD8 polyA tail | CTD | PMID:30157460 | all-trans-retinoic acid | affects expression | ISO | RGD:1350514 | 6480464 | Tretinoin affects the expression of FZD8 mRNA | CTD | PMID:31600526 | antirheumatic drug | decreases expression | ISO | RGD:1350514 | 6480464 | Antirheumatic Agents results in decreased expression of FZD8 mRNA | CTD | PMID:24449571 | atrazine | multiple interactions | ISO | RGD:1350514 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of FZD8 mRNA | CTD | PMID:18585445 | atrazine | increases expression | ISO | RGD:1350514 | 6480464 | Atrazine results in increased expression of FZD8 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | RGD:1558526 | 6480464 | Benzo(a)pyrene results in increased expression of FZD8 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | RGD:1350514 | 6480464 | Benzo(a)pyrene results in increased methylation of FZD8 exon, Benzo(a)pyrene results in increased methylation of FZD8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | RGD:1558526 | 6480464 | Benzo(a)pyrene results in decreased expression of FZD8 mRNA | CTD | PMID:27195522 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of FZD8 mRNA | CTD | PMID:25181051 more ... | butanal | decreases expression | ISO | RGD:1350514 | 6480464 | butyraldehyde results in decreased expression of FZD8 mRNA | CTD | PMID:26079696 | cadmium dichloride | increases expression | ISO | RGD:1558526 | 6480464 | Cadmium Chloride results in increased expression of FZD8 mRNA | CTD | PMID:20478370 | camptothecin | decreases methylation | ISO | RGD:1350514 | 6480464 | Camptothecin results in decreased methylation of FZD8 gene | CTD | PMID:30720231 | carbamazepine | affects expression | ISO | RGD:1350514 | 6480464 | Carbamazepine affects the expression of FZD8 mRNA | CTD | PMID:25979313 | carbamazepine | affects expression | ISO | RGD:1558526 | 6480464 | Carbamazepine affects the expression of FZD8 mRNA | CTD | PMID:22634333 | carbon nanotube | decreases expression | ISO | RGD:1558526 | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | choline | multiple interactions | ISO | RGD:1558526 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | RGD:1558526 | 6480464 | chromium hexavalent ion affects the expression of FZD8 mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | RGD:1350514 | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of FZD8 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | ISO | RGD:1558526 | 6480464 | Clofibrate results in decreased expression of FZD8 mRNA | CTD | PMID:17585979 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of FZD8 mRNA | CTD | PMID:24386269 | copper atom | multiple interactions | ISO | RGD:1350514 | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of FZD8 mRNA | CTD | PMID:30911355 | copper(0) | multiple interactions | ISO | RGD:1350514 | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of FZD8 mRNA | CTD | PMID:30911355 | copper(II) sulfate | increases expression | ISO | RGD:1350514 | 6480464 | Copper Sulfate results in increased expression of FZD8 mRNA | CTD | PMID:19549813 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of FZD8 mRNA | CTD | PMID:26577399 | decabromodiphenyl ether | increases expression | ISO | RGD:1350514 | 6480464 | decabromobiphenyl ether results in increased expression of FZD8 mRNA | CTD | PMID:31326446 | deguelin | increases expression | ISO | RGD:1350514 | 6480464 | deguelin results in increased expression of FZD8 mRNA | CTD | PMID:19861542 | dextran sulfate | multiple interactions | ISO | RGD:1558526 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FZD8 mRNA | CTD | PMID:29950665 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of FZD8 mRNA | CTD | PMID:21266533 | dichloroacetic acid | decreases expression | ISO | RGD:1558526 | 6480464 | Dichloroacetic Acid results in decreased expression of FZD8 mRNA | CTD | PMID:28962523 | dorsomorphin | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | RGD:1350514 | 6480464 | entinostat results in decreased expression of FZD8 mRNA | CTD | PMID:26272509 | flusilazole | affects expression | ISO | RGD:1558526 | 6480464 | flusilazole affects the expression of FZD8 mRNA | CTD | PMID:22634333 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of FZD8 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | RGD:1558526 | 6480464 | [Folic Acid co-treated with sodium arsenite] results in decreased methylation of FZD8 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene | CTD | PMID:20938992, PMID:22959928 | furan | decreases expression | ISO | RGD:1558526 | 6480464 | furan results in decreased expression of FZD8 mRNA | CTD | PMID:24183702 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of FZD8 mRNA | CTD | PMID:24136188 | kenpaullone | decreases expression | EXP | | 6480464 | kenpaullone results in decreased expression of FZD8 mRNA | CTD | PMID:17993264 | kojic acid | increases expression | ISO | RGD:1350514 | 6480464 | kojic acid results in increased expression of FZD8 mRNA | CTD | PMID:16595896 | L-methionine | multiple interactions | ISO | RGD:1558526 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene | CTD | PMID:20938992 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of FZD8 mRNA | CTD | PMID:24136188 | levofloxacin | increases expression | EXP | | 6480464 | Levofloxacin results in increased expression of FZD8 mRNA | CTD | PMID:24136188 | methylisothiazolinone | increases expression | ISO | RGD:1350514 | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of FZD8 mRNA | CTD | PMID:31629900 | methylmercury chloride | decreases expression | ISO | RGD:1350514 | 6480464 | methylmercuric chloride results in decreased expression of FZD8 mRNA | CTD | PMID:23179753 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of FZD8 mRNA | CTD | PMID:25380136 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of FZD8 mRNA | CTD | PMID:24136188 | nickel atom | decreases expression | ISO | RGD:1350514 | 6480464 | Nickel results in decreased expression of FZD8 mRNA | CTD | PMID:25583101 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of FZD8 mRNA | CTD | PMID:24136188 | ozone | decreases expression | ISO | RGD:1558526 | 6480464 | Ozone results in decreased expression of FZD8 mRNA | CTD | PMID:31626304 | panobinostat | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | ISO | RGD:1350514 | 6480464 | Acetaminophen results in increased expression of FZD8 mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of FZD8 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of FZD8 mRNA | CTD | PMID:32680482 | phenylmercury acetate | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA | CTD | PMID:27188386 | phenylmercury acetate | decreases expression | ISO | RGD:1350514 | 6480464 | Phenylmercuric Acetate results in decreased expression of FZD8 mRNA | CTD | PMID:26272509 | pirinixic acid | decreases expression | ISO | RGD:1558526 | 6480464 | pirinixic acid results in decreased expression of FZD8 mRNA | CTD | PMID:18445702 | SB 431542 | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:1558526 | 6480464 | Silicon Dioxide results in decreased expression of FZD8 mRNA | CTD | PMID:23221170 | silicon dioxide | decreases expression | ISO | RGD:1350514 | 6480464 | Silicon Dioxide analog results in decreased expression of FZD8 mRNA | CTD | PMID:25895662 | sodium arsenite | multiple interactions | ISO | RGD:1558526 | 6480464 | [Folic Acid co-treated with sodium arsenite] results in decreased methylation of FZD8 mRNA | CTD | PMID:22959928 | sodium arsenite | increases expression | ISO | RGD:1350514 | 6480464 | sodium arsenite results in increased expression of FZD8 mRNA | CTD | PMID:34032870 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of FZD8 mRNA | CTD | PMID:22110744 | tamoxifen | decreases expression | ISO | RGD:1558526 | 6480464 | Tamoxifen results in decreased expression of FZD8 mRNA | CTD | PMID:25123088 | Tetrachlorobisphenol A | increases expression | ISO | RGD:1350514 | 6480464 | tetrachlorodian results in increased expression of FZD8 mRNA | CTD | PMID:31326446 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of FZD8 mRNA | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | RGD:1558526 | 6480464 | Carbon Tetrachloride results in decreased expression of FZD8 mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FZD8 mRNA] | CTD | PMID:31150632 | thalidomide | decreases expression | ISO | RGD:1350514 | 6480464 | Thalidomide results in decreased expression of FZD8 mRNA | CTD | PMID:24154490 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of FZD8 mRNA | CTD | PMID:23411599 | titanium dioxide | multiple interactions | ISO | RGD:1558526 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FZD8 mRNA | CTD | PMID:29950665 | trichloroethene | decreases expression | ISO | RGD:1558526 | 6480464 | Trichloroethylene results in decreased expression of FZD8 mRNA | CTD | PMID:25549359 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of FZD8 mRNA | CTD | PMID:33387578 | trichostatin A | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA | CTD | PMID:27188386 | trichostatin A | decreases expression | ISO | RGD:1350514 | 6480464 | trichostatin A results in decreased expression of FZD8 mRNA | CTD | PMID:26272509 | troglitazone | decreases expression | ISO | RGD:1558526 | 6480464 | troglitazone results in decreased expression of FZD8 mRNA | CTD | PMID:28973697 | valproic acid | multiple interactions | ISO | RGD:1350514 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | RGD:1350514 | 6480464 | Valproic Acid affects the expression of FZD8 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RGD:1350514 | 6480464 | Valproic Acid results in decreased expression of FZD8 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | RGD:1558526 | 6480464 | Valproic Acid affects the expression of FZD8 mRNA | CTD | PMID:17963808 | valproic acid | increases methylation | ISO | RGD:1350514 | 6480464 | Valproic Acid results in increased methylation of FZD8 gene | CTD | PMID:29154799 | |