Bp343 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp343 (Blood pressure QTL 343) Rattus norvegicus

Symbol: Bp343
Name: Blood pressure QTL 343
RGD ID: 2313854
Trait: life span trait   (VT:0005372)    
Measurement Type: age at time of death   (CMO:0001193)    
LOD Score: 3.9
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81732,199,534 - 55,604,694RGD_MAPPER_PIPELINE
mRatBN7.21731,990,784 - 50,909,196RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01733,303,627 - 53,475,276RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01735,195,242 - 51,171,794RGDRnor5.0
RGSC_v3.41738,353,858 - 59,104,944RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SD-Tg(Ren2)27 LEW/NHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Agtr1a is a candidate Gene for Bp343


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Rathypertension no_associationIAGP 619627 RGD 
Bp343Ratmalignant hypertension  IDA 619627 RGD 
Bp343Ratmalignant hypertension  IAGP 619627 RGD 
Bp343RatPolyuria  IAGP 619627 RGD 
Bp343Ratvisual epilepsy  IAGP 619627 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Ratabnormal induced morbidity/mortality  IDA 619627 RGD 
Bp343Ratabnormal pilomotor reflex  IDA 619627 RGD 
Bp343Ratincreased systemic arterial blood pressure no_associationIDA 619627 RGD 
Bp343Ratlethargy  IDA 619627 RGD 
Bp343Ratmortality/aging  IDA 619627 RGD 
Bp343Ratseizures  IDA 619627 RGD 
Bp343Ratweight loss  IDA 619627 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Ratage at time of death  IDA 619627 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Ratcontrol condition  IDA 619627 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Ratin vivo visual assessment  IDA 619627 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343RatLEW/NHsd  IEA 619627 RGD 
Bp343RatSD-Tg(Ren2)27  IEA 619627 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp343Ratlife span trait  IDA 619627 RGD 


#
Reference Title
Reference Citation
1. Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kantachuvesiri S, etal., Kidney Int 1999 Aug;56(2):414-20.

Related QTL Description Reference
Bp342 interacts with RGD:619627



1 to 20 of 363 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1311008GmdsGDP-mannose 4, 6-dehydratase173209531532621975Rat
1589718Foxc1forkhead box C1173263137932635361Rat
41035220LOC120098017U2 spliceosomal RNA173282822332828285Rat
1589717Foxf2forkhead box F2173283573032842547Rat
41355240LOC120097779uncharacterized LOC120097779173284257832848184Rat
621572Foxq1forkhead box Q1173291274432915377Rat
41110843LOC120098004small nucleolar RNA SNORA17173312192033122044Rat
9173217LOC103694077uncharacterized LOC103694077173322894933251259Rat
6490193Rps9-ps1ribosomal protein S9, pseudogene 1173347005933470620Rat
619961Exoc2exocyst complex component 2173350628933698246Rat
1585035Hus1bHUS1 checkpoint clamp component B173353403233535199Rat
7707333Rps11-ps4ribosomal protein S11, pseudogene 4173355257233553085Rat
14398591Mir6319-1microRNA mir-6319-1173358671533586841Rat
41164048LOC120097838uncharacterized LOC120097838173358677133620238Rat
1308050Irf4interferon regulatory factor 4173372180033742570Rat
1307146Dusp22dual specificity phosphatase 22173378098033831241Rat
11471267LOC108348556uncharacterized LOC108348556173393810033941366Rat
7659104Gyg1-ps1glycogenin 1, pseudogene 1173396983933972043Rat
628838Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1173397790833982478Rat
2070Agtr1aangiotensin II receptor, type 1a173417344634226892Rat

1 to 20 of 363 rows
1 to 20 of 243 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10119D17Arb4244173422548134225727Ratregion
10119D17Arb4244173422548134225872Ratregion
10119D17Arb4244173422556634225727Ratregion
10709D17Mgh3112174142981541429923Ratregion
11150D17Wox11134173787123537871375Ratregion
11151D17Wox18232173787115737871389Ratregion
33882D17Mit2129173199078431990913Ratregion
34120D17Mgh597175090909950909196Ratregion
34122D17Mgh8157175090909650909253Ratregion
35985D17Rat20163173852519738525360Ratregion
36011D17Rat17157173583708535837242Ratregion
36259D17Rat19155174022395240224109Ratregion
37322D17Rat69167173790963437909801Ratregion
37402D17Rat78156174054004140540197Ratregion
35400D17Rat21134174804353148043665Ratregion
37008D17Rat24169174956791149568080Ratregion
36614D17Rat22177174766694547667122Ratregion
36669D17Rat23175174799977347999948Ratregion
34809D17Rat26128174935480949354937Ratregion
35697D17Rat16153173455084334551001Ratregion
1 to 20 of 243 rows

Flank 1: (D17Mit2)
Rat AssemblyChrPosition (strand)Source
GRCr81732,199,534 - 32,199,663 (+)Marker Load Pipeline
mRatBN7.21731,990,784 - 31,990,913 (+)MAPPER
Rnor_6.01733,303,627 - 33,303,755NCBI
Rnor_5.01735,195,242 - 35,195,370UniSTS
RGSC_v3.41738,353,858 - 38,353,987RGD
RGSC_v3.41738,353,859 - 38,353,987UniSTS
RGSC_v3.11738,356,700 - 38,356,828RGD
Celera1731,553,047 - 31,553,175UniSTS
RH 3.4 Map17373.9UniSTS
RH 3.4 Map17373.9RGD
RH 2.0 Map17267.3RGD
SHRSP x BN Map1725.62RGD
FHH x ACI Map1730.0699RGD
Cytogenetic Map17p12UniSTS
Peak: (Agtr1a)
Rat AssemblyChrPosition (strand)Source
GRCr81734,383,397 - 34,435,523 (-)NCBI
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBI
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBI
Rnor_6.01735,907,102 - 35,958,136 (-)NCBI
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)Ensembl
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBI
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBI
Cytogenetic Map17p12NCBI
Flank 2: (D17Mgh5)
Rat AssemblyChrPosition (strand)Source
GRCr81755,604,597 - 55,604,694 (+)Marker Load Pipeline
mRatBN7.21750,909,099 - 50,909,196 (+)MAPPER
Rnor_6.01753,475,180 - 53,475,276NCBI
Rnor_5.01751,171,698 - 51,171,794UniSTS
RGSC_v3.41759,104,847 - 59,104,944RGD
RGSC_v3.41759,104,848 - 59,104,944UniSTS
RGSC_v3.11759,107,688 - 59,107,785RGD
Celera1746,929,911 - 46,930,007UniSTS
RH 3.4 Map17532.99UniSTS
RH 3.4 Map17532.99RGD
RH 2.0 Map17455.1RGD
SHRSP x BN Map1730.3699RGD
FHH x ACI Map1736.6499RGD
Cytogenetic Map17q12.1UniSTS


1 to 10 of 62 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat

1 to 10 of 62 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general number of animals used: 252 males 619627
qtl_general measurement method: two F1 populations were produced by SD-Tg(Ren2)27 males and F344 and LEW females; animals which had no symptoms of MH (polyuria, weight loss lethargy, hemiparesis, piloerection, seizure and lethality) by 120 days of age were marked as survived and the age of death of the others was noted 619627
qtl_general locus responsible for the reduction of life span by 6.9+-1.6 days and increased the probability of MH by 2.6 fold 619627
qtl_general this locus has no effect on blood pressure 619627
qtl_general higher ACE activity was noticed in F344 progeny as compard to LEW progeny 619627