Cdkal1 (CDK5 regulatory subunit associated protein 1-like 1) - Rat Genome Database

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Gene: Cdkal1 (CDK5 regulatory subunit associated protein 1-like 1) Rattus norvegicus
Analyze
Symbol: Cdkal1
Name: CDK5 regulatory subunit associated protein 1-like 1
RGD ID: 1310246
Description: Predicted to enable N6-threonylcarbomyladenosine methylthiotransferase activity. Predicted to be involved in tRNA methylthiolation. Predicted to act upstream of or within maintenance of translational fidelity. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; diabetic retinopathy; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; cadmium dichloride; diallyl disulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDK5 regulatory subunit-associated protein 1-like 1; LOC361243; threonylcarbamoyladenosine tRNA methylthiotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,927,221 - 35,479,827 (+)NCBIGRCr8
mRatBN7.21734,718,701 - 35,271,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,718,687 - 35,407,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,538,315 - 35,091,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01736,142,191 - 36,695,255 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01734,534,125 - 35,088,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01736,451,031 - 37,157,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1736,451,058 - 37,295,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,759,260 - 37,935,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01738,780,937 - 39,026,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41741,208,037 - 41,259,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11741,211,591 - 42,031,602 (+)NCBI
Celera1734,245,172 - 34,795,596 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Cho YM, etal., Diabetologia. 2009 Feb;52(2):253-61. Epub 2008 Nov 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. Kang ES, etal., Transplantation. 2009 Sep 15;88(5):693-8.
4. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. Lee YH, etal., J Hum Genet. 2008;53(11-12):991-8. Epub 2008 Nov 11.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, etal., Sci Rep. 2017 Aug 18;7(1):8812. doi: 10.1038/s41598-017-09010-w.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Takeuchi F, etal., Diabetes. 2009 Jul;58(7):1690-9. Epub 2009 Apr 28.
12. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Wu Y, etal., Diabetes. 2008 Oct;57(10):2834-42. Epub 2008 Jul 15.
Additional References at PubMed
PMID:19946888   PMID:20584901   PMID:21151568   PMID:21841312   PMID:23048041  


Genomics

Comparative Map Data
Cdkal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,927,221 - 35,479,827 (+)NCBIGRCr8
mRatBN7.21734,718,701 - 35,271,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,718,687 - 35,407,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,538,315 - 35,091,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01736,142,191 - 36,695,255 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01734,534,125 - 35,088,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01736,451,031 - 37,157,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1736,451,058 - 37,295,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,759,260 - 37,935,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01738,780,937 - 39,026,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41741,208,037 - 41,259,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11741,211,591 - 42,031,602 (+)NCBI
Celera1734,245,172 - 34,795,596 (+)NCBICelera
Cytogenetic Map17p12NCBI
CDKAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38620,534,457 - 21,232,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl620,534,457 - 21,232,404 (+)EnsemblGRCh38hg38GRCh38
GRCh37620,534,688 - 21,232,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36620,642,667 - 21,339,743 (+)NCBINCBI36Build 36hg18NCBI36
Build 34620,642,735 - 21,340,611NCBI
Celera621,767,810 - 22,465,949 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef620,478,924 - 21,176,389 (+)NCBIHuRef
CHM1_1620,536,980 - 21,234,732 (+)NCBICHM1_1
T2T-CHM13v2.0620,406,474 - 21,104,535 (+)NCBIT2T-CHM13v2.0
Cdkal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391329,375,729 - 30,039,665 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1329,375,729 - 30,039,657 (-)EnsemblGRCm39 Ensembl
GRCm381329,191,746 - 29,855,683 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1329,191,746 - 29,855,674 (-)EnsemblGRCm38mm10GRCm38
MGSCv371329,417,175 - 29,947,457 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361329,332,771 - 29,863,053 (-)NCBIMGSCv36mm8
Celera1329,544,145 - 30,074,351 (-)NCBICelera
Cytogenetic Map13A3.1- A3.2NCBI
cM Map1312.93NCBI
Cdkal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554835,398,687 - 5,993,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554835,398,748 - 5,993,071 (-)NCBIChiLan1.0ChiLan1.0
CDKAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2535,169,090 - 35,873,476 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1631,168,553 - 31,872,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0620,357,897 - 21,064,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1620,705,442 - 21,406,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl620,717,011 - 21,405,566 (+)Ensemblpanpan1.1panPan2
CDKAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13519,138,904 - 19,802,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3519,138,918 - 19,929,429 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3519,097,701 - 19,733,284 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03519,243,019 - 19,912,717 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3519,243,048 - 19,884,903 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13519,051,408 - 19,686,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03519,116,398 - 19,751,523 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03520,535,347 - 21,171,070 (+)NCBIUU_Cfam_GSD_1.0
Cdkal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049465,340,519 - 5,897,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365525,833,409 - 6,347,017 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365525,903,042 - 6,347,498 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl715,910,666 - 16,626,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1715,910,645 - 16,569,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2716,819,882 - 17,480,999 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11750,970,764 - 51,673,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1750,970,678 - 51,673,579 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604420,828,038 - 21,550,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247565,498,557 - 6,143,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkal1
3082 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:36
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000024854
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
D17Got48  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81735,346,775 - 35,347,060 (+)Marker Load Pipeline
mRatBN7.21735,138,218 - 35,138,503 (+)MAPPERmRatBN7.2
Rnor_6.01737,027,460 - 37,027,744NCBIRnor6.0
Rnor_5.01738,895,524 - 38,895,808UniSTSRnor5.0
RGSC_v3.41741,636,531 - 41,636,816RGDRGSC3.4
RGSC_v3.41741,636,532 - 41,636,816UniSTSRGSC3.4
RGSC_v3.11741,639,373 - 41,639,657RGD
Celera1734,663,702 - 34,663,986UniSTS
RH 3.4 Map17389.7RGD
RH 3.4 Map17389.7UniSTS
RH 2.0 Map17290.7RGD
Cytogenetic Map17p12UniSTS
RH131644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,114,998 - 35,115,194 (+)MAPPERmRatBN7.2
Rnor_6.01737,004,240 - 37,004,435NCBIRnor6.0
Rnor_5.01738,872,304 - 38,872,499UniSTSRnor5.0
RGSC_v3.41741,613,312 - 41,613,507UniSTSRGSC3.4
Celera1734,640,482 - 34,640,677UniSTS
RH 3.4 Map17393.5UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001402171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ935002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024854   ⟹   ENSRNOP00000024854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,723,968 - 35,271,353 (+)Ensembl
Rnor_6.0 Ensembl1736,956,385 - 37,295,069 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071408   ⟹   ENSRNOP00000065627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,718,687 - 35,407,524 (+)Ensembl
Rnor_6.0 Ensembl1736,451,058 - 36,627,167 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111226   ⟹   ENSRNOP00000084071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,723,968 - 34,768,709 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116835   ⟹   ENSRNOP00000081920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,723,968 - 34,736,941 (+)Ensembl
RefSeq Acc Id: NM_001402171   ⟹   NP_001389100
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,280 - 35,479,827 (+)NCBI
mRatBN7.21734,718,701 - 35,271,276 (+)NCBI
RefSeq Acc Id: NM_001402172   ⟹   NP_001389101
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,280 - 34,945,520 (+)NCBI
mRatBN7.21734,718,701 - 34,736,941 (+)NCBI
RefSeq Acc Id: XM_063276593   ⟹   XP_063132663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,265 - 35,479,827 (+)NCBI
RefSeq Acc Id: XM_063276594   ⟹   XP_063132664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,222 - 35,479,827 (+)NCBI
RefSeq Acc Id: XM_063276596   ⟹   XP_063132666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,377 - 35,479,827 (+)NCBI
RefSeq Acc Id: XM_063276597   ⟹   XP_063132667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,222 - 35,412,788 (+)NCBI
RefSeq Acc Id: XM_063276598   ⟹   XP_063132668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,221 - 35,284,769 (+)NCBI
RefSeq Acc Id: XM_063276599   ⟹   XP_063132669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,222 - 35,280,539 (+)NCBI
RefSeq Acc Id: XM_063276600   ⟹   XP_063132670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,927,267 - 35,280,539 (+)NCBI
RefSeq Acc Id: XM_063276601   ⟹   XP_063132671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81735,081,164 - 35,479,827 (+)NCBI
Ensembl Acc Id: ENSRNOP00000065627   ⟸   ENSRNOT00000071408
Ensembl Acc Id: ENSRNOP00000024854   ⟸   ENSRNOT00000024854
Ensembl Acc Id: ENSRNOP00000084071   ⟸   ENSRNOT00000111226
Ensembl Acc Id: ENSRNOP00000081920   ⟸   ENSRNOT00000116835
RefSeq Acc Id: NP_001389100   ⟸   NM_001402171
- Peptide Label: isoform 1
- UniProtKB: F1LV76 (UniProtKB/TrEMBL),   A6J7N5 (UniProtKB/TrEMBL),   K9N0M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001389101   ⟸   NM_001402172
- Peptide Label: isoform 2
- UniProtKB: A0A8I5ZT83 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132668   ⟸   XM_063276598
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132664   ⟸   XM_063276594
- Peptide Label: isoform X1
- UniProtKB: A6J7N5 (UniProtKB/TrEMBL),   F1LV76 (UniProtKB/TrEMBL),   K9N0M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132667   ⟸   XM_063276597
- Peptide Label: isoform X2
- UniProtKB: A6J7N6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132669   ⟸   XM_063276599
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132663   ⟸   XM_063276593
- Peptide Label: isoform X1
- UniProtKB: A6J7N5 (UniProtKB/TrEMBL),   F1LV76 (UniProtKB/TrEMBL),   K9N0M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132670   ⟸   XM_063276600
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132666   ⟸   XM_063276596
- Peptide Label: isoform X1
- UniProtKB: A6J7N5 (UniProtKB/TrEMBL),   F1LV76 (UniProtKB/TrEMBL),   K9N0M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132671   ⟸   XM_063276601
- Peptide Label: isoform X5
Protein Domains
MTTase N-terminal   Radical SAM core   TRAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV76-F1-model_v2 AlphaFold F1LV76 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310246 AgrOrtholog
BioCyc Gene G2FUF-9519 BioCyc
Ensembl Genes ENSRNOG00000018381 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024854.8 UniProtKB/TrEMBL
  ENSRNOT00000071408.3 UniProtKB/TrEMBL
  ENSRNOT00000111226.1 UniProtKB/TrEMBL
  ENSRNOT00000116835.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.750.200 UniProtKB/TrEMBL
  3.40.50.12160 UniProtKB/TrEMBL
  3.80.30.20 UniProtKB/TrEMBL
InterPro Elp3/MiaB/NifB UniProtKB/TrEMBL
  Methylthiotransferase UniProtKB/TrEMBL
  Methylthiotransferase_CS UniProtKB/TrEMBL
  Methylthiotransferase_N UniProtKB/TrEMBL
  Methylthiotransferase_N_sf UniProtKB/TrEMBL
  MiaB-like_B UniProtKB/TrEMBL
  rSAM UniProtKB/TrEMBL
  rSAM_horseshoe UniProtKB/TrEMBL
  TRAM_dom UniProtKB/TrEMBL
NCBI Gene 361243 ENTREZGENE
PANTHER RADICAL SAM PROTEINS UniProtKB/TrEMBL
  THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE UniProtKB/TrEMBL
Pfam Radical_SAM UniProtKB/TrEMBL
  TRAM UniProtKB/TrEMBL
  UPF0004 UniProtKB/TrEMBL
PhenoGen Cdkal1 PhenoGen
PROSITE MTTASE_N UniProtKB/TrEMBL
  MTTASE_RADICAL UniProtKB/TrEMBL
  RADICAL_SAM UniProtKB/TrEMBL
  TRAM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018381 RatGTEx
SMART Elp3 UniProtKB/TrEMBL
Superfamily-SCOP Radical SAM enzymes UniProtKB/TrEMBL
UniProt A0A8I5ZT83 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBE9_RAT UniProtKB/TrEMBL
  A6J7N5 ENTREZGENE, UniProtKB/TrEMBL
  A6J7N6 ENTREZGENE, UniProtKB/TrEMBL
  F1LV76 ENTREZGENE, UniProtKB/TrEMBL
  K9N0M9 ENTREZGENE, UniProtKB/TrEMBL
  M0R837_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cdkal1  CDK5 regulatory subunit associated protein 1-like 1   Cdkal1_predicted  CDK5 regulatory subunit associated protein 1-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cdkal1_predicted  CDK5 regulatory subunit associated protein 1-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED