Gene: Hfe (homeostatic iron regulator) Rattus norvegicus
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Symbol: Hfe
Name: homeostatic iron regulator
Description: ENCODES a protein that exhibits beta-2-microglobulin binding (ortholog); co-receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN acute-phase response; cellular response to iron ion starvation; female pregnancy; ASSOCIATED WITH Alcoholic Liver Diseases; Alzheimer's disease (ortholog); Alzheimer's disease 1 (ortholog); FOUND IN apical part of cell; terminal web; basal part of cell (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hemochromatosis; hereditary hemochromatosis protein homolog; RT1-CAFE
Orthologs:
Homo sapiens (human) : HFE (homeostatic iron regulator)  HGNC  Alliance
Mus musculus (house mouse) : Hfe (hemochromatosis)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hfe (homeostatic iron regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : HFE (homeostatic iron regulator)
Canis lupus familiaris (dog) : HFE (homeostatic iron regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hfe (homeostatic iron regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01743,661,276 - 43,669,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01745,515,737 - 45,523,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,469,927 - 48,478,502 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X40,352,010 - 40,353,825 (-)NCBI
Celera1741,045,860 - 41,053,914 (+)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hfe
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2793
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-11-20
Status: ACTIVE