Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hfe (homeostatic iron regulator) Rattus norvegicus
Symbol: Hfe
Name: homeostatic iron regulator
RGD ID: 2793
Description: Predicted to have beta-2-microglobulin binding activity; co-receptor binding activity; and transferrin receptor binding activity. Involved in several processes, including acute-phase response; liver regeneration; and response to starvation. Localizes to apical part of cell; plasma membrane; and terminal web. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hemochromatosis; hereditary hemochromatosis protein homolog; RT1-CAFE
Homo sapiens (human) : HFE (homeostatic iron regulator)  HGNC  Alliance
Mus musculus (house mouse) : Hfe (homeostatic iron regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hfe (homeostatic iron regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : HFE (homeostatic iron regulator)
Canis lupus familiaris (dog) : HFE (homeostatic iron regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hfe (homeostatic iron regulator)
Sus scrofa (pig) : HFE (homeostatic iron regulator)
Chlorocebus sabaeus (African green monkey) : HFE (homeostatic iron regulator)
Heterocephalus glaber (naked mole-rat) : Hfe (homeostatic iron regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01743,661,276 - 43,669,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,661,222 - 43,669,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,515,737 - 45,523,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,469,927 - 48,478,502 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X40,352,010 - 40,353,825 (-)NCBI
Celera1741,045,860 - 41,053,914 (+)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hfe
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2793
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.