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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | increases expression | ISO | RGD:1343213 | 6480464 | Demecolcine results in increased expression of H2BC21 mRNA | CTD | PMID:23649840 | (S)-nicotine | decreases expression | ISO | RGD:1620830 | 6480464 | Nicotine results in decreased expression of H2BC4 mRNA | CTD | PMID:17456735 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1620830 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of HIST1H2BC mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1620830 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H2BC4 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | RGD:1343213 | 6480464 | Estradiol results in decreased expression of H2BC21 mRNA | CTD | PMID:16474171 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | RGD:1620830 | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1620830 | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2BC4 mRNA | CTD | PMID:21570461, PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1343213 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2BC21 mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1343213 | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2BC21 mRNA | CTD | PMID:22574217 | 2-hydroxypropanoic acid | increases expression | ISO | RGD:1343213 | 6480464 | Lactic Acid results in increased expression of H2BC21 mRNA | CTD | PMID:30851411 | 3-methylcholanthrene | multiple interactions | ISO | RGD:1343213 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to H2BC21 promoter] | CTD | PMID:20348232 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1620830 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of HIST1H2BC mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1343213 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of H2BC21 protein | CTD | PMID:34186270 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of HIST1H2BC mRNA | CTD | PMID:24780913 | acrylamide | decreases expression | ISO | RGD:1343213 | 6480464 | Acrylamide results in decreased expression of H2BC21 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | RGD:1343213 | 6480464 | Aflatoxin B1 results in increased expression of H2BC21 mRNA | CTD | PMID:21641981, PMID:27153756 | aflatoxin B1 | decreases methylation | ISO | RGD:1343213 | 6480464 | Aflatoxin B1 results in decreased methylation of H2BC21 gene | CTD | PMID:27153756 | aldehydo-D-glucose | increases expression | ISO | RGD:1620830 | 6480464 | Glucose results in increased expression of H2BC4 mRNA | CTD | PMID:17178593 | all-trans-retinoic acid | increases expression | ISO | RGD:1343213 | 6480464 | Tretinoin results in increased expression of H2BC21 mRNA, Tretinoin results in increased expression of HIST1H2BC mRNA | CTD | PMID:16249480, PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HIST1H2BC mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | RGD:1343213 | 6480464 | aristolochic acid I results in increased expression of HIST1H2BC mRNA | CTD | PMID:33212167 | atrazine | increases expression | ISO | RGD:1343213 | 6480464 | Atrazine results in increased expression of H2BC21 mRNA | CTD | PMID:22378314 | azathioprine | increases expression | ISO | RGD:1343213 | 6480464 | Azathioprine results in increased expression of H2BC21 mRNA | CTD | PMID:22623647 | benzene | decreases expression | ISO | RGD:1343213 | 6480464 | Benzene results in decreased expression of H2BC21 mRNA | CTD | PMID:19162166 | benzo[a]pyrene | increases expression | ISO | RGD:1620830 | 6480464 | Benzo(a)pyrene results in increased expression of H2BC4 mRNA | CTD | PMID:22228805, PMID:22610609 | benzo[a]pyrene | increases expression | ISO | RGD:1343213 | 6480464 | Benzo(a)pyrene results in increased expression of H2BC21 mRNA, Benzo(a)pyrene results in increased expression of H2BC21 protein | CTD | PMID:20106945 more ... | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:1343213 | 6480464 | 7 more ... | CTD | PMID:19150397, PMID:20382639 | benzo[b]fluoranthene | increases expression | ISO | RGD:1620830 | 6480464 | benzo(b)fluoranthene results in increased expression of H2BC4 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | ISO | RGD:1343213 | 6480464 | bisphenol A results in decreased expression of H2BC21 mRNA, bisphenol A results in decreased expression of H2BC21 protein | CTD | PMID:16474171, PMID:34186270 | bisphenol F | increases expression | ISO | RGD:1620830 | 6480464 | bisphenol F results in increased expression of HIST1H2BC mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | RGD:1343213 | 6480464 | bisphenol F results in increased expression of H2BC21 protein | CTD | PMID:34186270 | butanal | decreases expression | ISO | RGD:1343213 | 6480464 | butyraldehyde results in decreased expression of H2BC21 mRNA | CTD | PMID:26079696 | carbon nanotube | decreases expression | ISO | RGD:1620830 | 6480464 | Nanotubes more ... | CTD | PMID:25554681, PMID:25620056 | CGP 52608 | multiple interactions | ISO | RGD:1343213 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to H2BC21 gene] | CTD | PMID:28238834 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of HIST1H2BC protein | CTD | PMID:22023808 | copper atom | multiple interactions | ISO | RGD:1343213 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of H2BC21 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1343213 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of H2BC21 mRNA | CTD | PMID:20971185 | copper(II) chloride | decreases expression | ISO | RGD:1343213 | 6480464 | cupric chloride results in decreased expression of H2BC21 mRNA | CTD | PMID:34921933 | copper(II) sulfate | increases expression | ISO | RGD:1343213 | 6480464 | Copper Sulfate results in increased expression of H2BC21 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1343213 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of H2BC21 mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:1343213 | 6480464 | Coumestrol results in decreased expression of H2BC21 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:1343213 | 6480464 | Asbestos, Crocidolite results in increased expression of H2BC21 mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | RGD:1620830 | 6480464 | Cyclosporine results in increased expression of H2BC4 mRNA | CTD | PMID:19770486 | cyclosporin A | increases expression | ISO | RGD:1343213 | 6480464 | Cyclosporine results in increased expression of H2BC21 mRNA | CTD | PMID:20106945 more ... | D-glucose | increases expression | ISO | RGD:1620830 | 6480464 | Glucose results in increased expression of H2BC4 mRNA | CTD | PMID:17178593 | dibutyl phthalate | decreases expression | ISO | RGD:1620830 | 6480464 | Dibutyl Phthalate results in decreased expression of H2BC4 mRNA | CTD | PMID:21266533 | dimethylarsinous acid | decreases expression | ISO | RGD:1343213 | 6480464 | dimethylarsinous acid results in decreased expression of H2BC21 mRNA | CTD | PMID:23876855 | dioxygen | decreases expression | ISO | RGD:1343213 | 6480464 | Oxygen deficiency results in decreased expression of H2BC21 mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | RGD:1343213 | 6480464 | Doxorubicin results in increased expression of H2BC21 mRNA | CTD | PMID:29803840 | doxorubicin | affects expression | ISO | RGD:1343213 | 6480464 | Doxorubicin affects the expression of H2BC21 mRNA | CTD | PMID:25529476 | Enterolactone | multiple interactions | ISO | RGD:1343213 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of H2BC21 mRNA | CTD | PMID:19167446 | entinostat | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | RGD:1343213 | 6480464 | entinostat results in decreased expression of H2BC21 mRNA | CTD | PMID:26272509, PMID:27188386 | folic acid | multiple interactions | ISO | RGD:1620830 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H2BC4 mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | RGD:1343213 | 6480464 | Formaldehyde results in increased expression of H2BC21 mRNA | CTD | PMID:20655997 more ... | furan | increases expression | EXP | | 6480464 | furan results in increased expression of HIST1H2BC mRNA | CTD | PMID:25539665 | genistein | decreases expression | ISO | RGD:1343213 | 6480464 | Genistein results in decreased expression of H2BC21 mRNA | CTD | PMID:16474171 | gentamycin | multiple interactions | ISO | RGD:1620830 | 6480464 | trichostatin A inhibits the reaction [Gentamicins results in decreased acetylation of H2BC4 protein] | CTD | PMID:19141081 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HIST1H2BC mRNA | CTD | PMID:33387578 | gentamycin | decreases acetylation | ISO | RGD:1620830 | 6480464 | Gentamicins results in decreased acetylation of H2BC4 protein | CTD | PMID:19141081 | glucose | increases expression | ISO | RGD:1620830 | 6480464 | Glucose results in increased expression of H2BC4 mRNA | CTD | PMID:17178593 | inulin | multiple interactions | ISO | RGD:1620830 | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HIST1H2BC mRNA | CTD | PMID:36331819 | isoflavones | affects expression | ISO | RGD:1343213 | 6480464 | Isoflavones affects the expression of H2BC21 mRNA | CTD | PMID:16365062 | isotretinoin | decreases expression | ISO | RGD:1343213 | 6480464 | Isotretinoin results in decreased expression of H2BC21 mRNA | CTD | PMID:20436886 | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of HIST1H2BC mRNA | CTD | PMID:28801915 | mercury dibromide | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | mercury dibromide | decreases expression | ISO | RGD:1343213 | 6480464 | mercuric bromide results in decreased expression of H2BC21 mRNA | CTD | PMID:26272509 | methyl methacrylate | increases expression | ISO | RGD:1620830 | 6480464 | Methylmethacrylate results in increased expression of H2BC4 mRNA | CTD | PMID:16916219 | methyl methanesulfonate | increases expression | ISO | RGD:1343213 | 6480464 | Methyl Methanesulfonate results in increased expression of H2BC21 mRNA | CTD | PMID:23649840 | methylisothiazolinone | increases expression | ISO | RGD:1343213 | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of H2BC21 mRNA | CTD | PMID:31629900 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | RGD:1343213 | 6480464 | N more ... | CTD | PMID:19013360 | N-methyl-4-phenylpyridinium | decreases expression | ISO | RGD:1343213 | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of H2BC21 mRNA | CTD | PMID:24810058 | N-methyl-N-nitrosourea | decreases expression | ISO | RGD:1620830 | 6480464 | Methylnitrosourea results in decreased expression of H2BC4 mRNA | CTD | PMID:25270620 | N-Nitrosopyrrolidine | decreases expression | ISO | RGD:1343213 | 6480464 | N-Nitrosopyrrolidine results in decreased expression of H2BC21 mRNA | CTD | PMID:32234424 | nicotine | decreases expression | ISO | RGD:1620830 | 6480464 | Nicotine results in decreased expression of H2BC4 mRNA | CTD | PMID:17456735 | okadaic acid | decreases expression | ISO | RGD:1620830 | 6480464 | Okadaic Acid results in decreased expression of H2BC4 mRNA | CTD | PMID:25270620 | p-chloromercuribenzoic acid | decreases expression | ISO | RGD:1343213 | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of H2BC21 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of HIST1H2BC mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RGD:1343213 | 6480464 | Acetaminophen results in increased expression of H2BC21 mRNA | CTD | PMID:21420995, PMID:29067470 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of HIST1H2BC mRNA | CTD | PMID:33387578 | paraoxon | decreases expression | ISO | RGD:1343213 | 6480464 | Paraoxon results in decreased expression of H2BC21 protein | CTD | PMID:20931991 | pentanal | decreases expression | ISO | RGD:1343213 | 6480464 | pentanal results in decreased expression of H2BC21 mRNA | CTD | PMID:26079696 | perfluorononanoic acid | decreases expression | ISO | RGD:1343213 | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of H2BC21 mRNA | CTD | PMID:32588087 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | RGD:1620830 | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HIST1H2BC mRNA | CTD | PMID:36331819 | perfluorooctanoic acid | increases expression | ISO | RGD:1343213 | 6480464 | perfluorooctanoic acid results in increased expression of H2BC21 mRNA | CTD | PMID:36326898 | phenylmercury acetate | decreases expression | ISO | RGD:1343213 | 6480464 | Phenylmercuric Acetate results in decreased expression of H2BC21 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | RGD:1620830 | 6480464 | pirinixic acid results in decreased expression of H2BC4 mRNA | CTD | PMID:18445702 | progesterone | increases expression | ISO | RGD:1620830 | 6480464 | Progesterone results in increased expression of H2BC4 mRNA | CTD | PMID:22238285 | propanal | decreases expression | ISO | RGD:1343213 | 6480464 | propionaldehyde results in decreased expression of H2BC21 mRNA | CTD | PMID:26079696 | rac-lactic acid | increases expression | ISO | RGD:1343213 | 6480464 | Lactic Acid results in increased expression of H2BC21 mRNA | CTD | PMID:30851411 | resveratrol | decreases expression | ISO | RGD:1343213 | 6480464 | Resveratrol results in decreased expression of H2BC21 mRNA | CTD | PMID:19371625 | rotenone | decreases expression | ISO | RGD:1343213 | 6480464 | Rotenone results in decreased expression of H2BC21 mRNA | CTD | PMID:29955902 | SB 431542 | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | RGD:1620830 | 6480464 | Silicon Dioxide results in increased expression of H2BC4 mRNA | CTD | PMID:19073995 | silicon dioxide | increases expression | ISO | RGD:1343213 | 6480464 | Silicon Dioxide analog results in increased expression of H2BC21 mRNA, Silicon Dioxide results in increased expression of H2BC21 mRNA | CTD | PMID:23806026 more ... | silver atom | decreases expression | ISO | RGD:1620830 | 6480464 | Silver results in decreased expression of H2BC4 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | RGD:1620830 | 6480464 | Silver results in decreased expression of H2BC4 mRNA | CTD | PMID:27131904 | sodium arsenite | decreases expression | ISO | RGD:1343213 | 6480464 | sodium arsenite results in decreased expression of H2BC21 mRNA | CTD | PMID:23876855 | sodium arsenite | increases expression | ISO | RGD:1343213 | 6480464 | sodium arsenite results in increased expression of H2BC21 mRNA | CTD | PMID:12679051, PMID:25266719 | sodium dichromate | increases expression | ISO | RGD:1620830 | 6480464 | sodium bichromate results in increased expression of HIST1H2BC mRNA | CTD | PMID:31558096 | sodium dodecyl sulfate | increases expression | ISO | RGD:1343213 | 6480464 | Sodium Dodecyl Sulfate results in increased expression of H2BC21 mRNA | CTD | PMID:31734321 | succimer | multiple interactions | ISO | RGD:1620830 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of H2BC4 mRNA | CTD | PMID:21641980 | sunitinib | decreases expression | ISO | RGD:1343213 | 6480464 | Sunitinib results in decreased expression of H2BC21 mRNA | CTD | PMID:31533062 | tetrachloromethane | affects expression | ISO | RGD:1620830 | 6480464 | Carbon Tetrachloride affects the expression of H2BC4 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | ISO | RGD:1620830 | 6480464 | Carbon Tetrachloride results in decreased expression of H2BC4 mRNA | CTD | PMID:31919559 | thalidomide | decreases expression | ISO | RGD:1620830 | 6480464 | Thalidomide results in decreased expression of H2BC4 mRNA | CTD | PMID:26217789 | titanium dioxide | decreases expression | ISO | RGD:1620830 | 6480464 | titanium dioxide results in decreased expression of H2BC4 mRNA | CTD | PMID:27760801 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of HIST1H2BC mRNA | CTD | PMID:33387578 | trichostatin A | multiple interactions | ISO | RGD:1620830 | 6480464 | trichostatin A inhibits the reaction [Gentamicins results in decreased acetylation of H2BC4 protein] | CTD | PMID:19141081 | trichostatin A | decreases expression | ISO | RGD:1343213 | 6480464 | trichostatin A results in decreased expression of H2BC21 mRNA | CTD | PMID:24935251 | triclosan | decreases expression | ISO | RGD:1343213 | 6480464 | Triclosan results in decreased expression of H2BC21 mRNA | CTD | PMID:30510588 | triptonide | decreases expression | ISO | RGD:1620830 | 6480464 | triptonide results in decreased expression of H2BC4 mRNA | CTD | PMID:33045310 | troglitazone | increases expression | ISO | RGD:1343213 | 6480464 | Troglitazone results in increased expression of H2BC21 mRNA | CTD | PMID:19140230 | trovafloxacin | decreases expression | ISO | RGD:1620830 | 6480464 | trovafloxacin results in decreased expression of H2BC4 mRNA | CTD | PMID:35537566 | valproic acid | multiple interactions | ISO | RGD:1343213 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | RGD:1343213 | 6480464 | Valproic Acid results in increased expression of H2BC21 mRNA | CTD | PMID:28001369 | valproic acid | affects expression | ISO | RGD:1343213 | 6480464 | Valproic Acid affects the expression of H2BC21 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | RGD:1343213 | 6480464 | Valproic Acid results in decreased methylation of H2BC21 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:1343213 | 6480464 | Valproic Acid results in decreased expression of H2BC21 mRNA | CTD | PMID:23179753 more ... | vincristine | increases expression | ISO | RGD:1343213 | 6480464 | Vincristine results in increased expression of H2BC21 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | ISO | RGD:1343213 | 6480464 | Vorinostat results in decreased expression of H2BC21 mRNA | CTD | PMID:27188386 | zoledronic acid | increases expression | ISO | RGD:1343213 | 6480464 | Zoledronic Acid results in increased expression of H2BC21 mRNA | CTD | PMID:24714768 | |