Gpld1 (glycosylphosphatidylinositol specific phospholipase D1) - Rat Genome Database

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Gene: Gpld1 (glycosylphosphatidylinositol specific phospholipase D1) Rattus norvegicus
Analyze
Symbol: Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
RGD ID: 631371
Description: Enables glycosylphosphatidylinositol phospholipase D activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; glycerophospholipid metabolic process; and regulation of triglyceride metabolic process. Located in extracellular space. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1); PARTICIPATES IN glycosylphosphatidylinositol anchor biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol phospholipase D; GPI-PLD; GPI-specific phospholipase D; phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,512,659 - 40,560,483 (-)NCBIGRCr8
mRatBN7.21740,084,427 - 40,132,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,084,617 - 40,126,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,152,671 - 40,195,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,756,723 - 41,799,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,038,148 - 40,082,405 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,085,027 - 42,131,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,085,028 - 42,127,678 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01743,952,824 - 44,000,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,145,567 - 47,188,345 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,148,408 - 47,191,186 (-)NCBI
Celera1739,722,211 - 39,764,466 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
glafenine  (EXP)
L-ethionine  (EXP)
leflunomide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration involved in sprouting angiogenesis  (IEA,ISO,ISS)
cellular response to calcium ion  (IEA,ISO)
cellular response to cholesterol  (IEA,ISO,ISS)
cellular response to insulin stimulus  (ISO,ISS)
cellular response to pH  (IEA,ISO,ISS)
cellular response to triglyceride  (IEA,ISO,ISS)
cellular response to xenobiotic stimulus  (IEA,ISO,ISS)
chondrocyte differentiation  (ISO,ISS)
complement receptor mediated signaling pathway  (IEA,ISO,ISS)
insulin receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of triglyceride catabolic process  (ISO,ISS)
obsolete GPI anchor release  (IBA,IEA,ISO,ISS)
ossification  (ISO,ISS)
phosphatidylcholine metabolic process  (ISS)
positive regulation of alkaline phosphatase activity  (ISS)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of endothelial cell migration  (IEA,ISO,ISS)
positive regulation of glucose metabolic process  (ISO,ISS)
positive regulation of high-density lipoprotein particle clearance  (ISO,ISS)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO,ISS)
positive regulation of membrane protein ectodomain proteolysis  (IEA,ISO,ISS)
positive regulation of secretion  (ISO,ISS)
positive regulation of triglyceride biosynthetic process  (ISO,ISS)
regulation of cellular response to insulin stimulus  (IEA,ISO,ISS)
response to glucose  (IEA,ISO,ISS)
transepithelial transport  (ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Insulin reduces serum glycosylphosphatidylinositol phospholipase D levels in human type I diabetic patients and streptozotocin diabetic rats. Schofield JN, etal., Mol Genet Metab 2002 Feb;75(2):154-61.
7. Enzymatic properties of phosphatidylinositol-glycan-specific phospholipase C from rat liver and phosphatidylinositol-glycan-specific phospholipase D from rat serum. Stieger S, etal., Eur J Biochem. 1991 Apr 10;197(1):67-73.
Additional References at PubMed
PMID:1833386   PMID:2760042   PMID:9716655   PMID:15907827   PMID:15946906   PMID:16219662   PMID:16822939   PMID:17720976   PMID:17761367   PMID:17897319   PMID:18328347   PMID:19135435  
PMID:20153004   PMID:23533145   PMID:30457913  


Genomics

Comparative Map Data
Gpld1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,512,659 - 40,560,483 (-)NCBIGRCr8
mRatBN7.21740,084,427 - 40,132,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,084,617 - 40,126,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,152,671 - 40,195,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,756,723 - 41,799,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,038,148 - 40,082,405 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,085,027 - 42,131,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,085,028 - 42,127,678 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01743,952,824 - 44,000,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,145,567 - 47,188,345 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,148,408 - 47,191,186 (-)NCBI
Celera1739,722,211 - 39,764,466 (-)NCBICelera
Cytogenetic Map17p11NCBI
GPLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,423,969 - 24,495,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,424,565 - 24,495,205 (-)EnsemblGRCh38hg38GRCh38
GRCh37624,426,060 - 24,489,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,536,384 - 24,597,829 (-)NCBINCBI36Build 36hg18NCBI36
Celera625,661,841 - 25,723,263 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,375,283 - 24,439,304 (-)NCBIHuRef
CHM1_1624,430,295 - 24,494,056 (-)NCBICHM1_1
T2T-CHM13v2.0624,295,865 - 24,365,025 (-)NCBIT2T-CHM13v2.0
Gpld1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,127,135 - 25,175,919 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,127,135 - 25,176,484 (+)EnsemblGRCm39 Ensembl
GRCm381324,937,785 - 24,991,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,943,152 - 24,992,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv371325,035,021 - 25,083,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,950,680 - 24,998,220 (+)NCBIMGSCv36mm8
Celera1325,173,821 - 25,222,605 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.79NCBI
Gpld1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,502,345 - 2,552,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,501,751 - 2,552,855 (+)NCBIChiLan1.0ChiLan1.0
GPLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,067,118 - 39,140,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,068,472 - 35,139,477 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,257,923 - 24,332,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,588,663 - 24,665,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,588,672 - 24,665,229 (-)Ensemblpanpan1.1panPan2
GPLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,495,001 - 22,556,264 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,495,073 - 22,554,105 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3522,463,025 - 22,523,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03522,617,050 - 22,678,177 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,615,700 - 22,678,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,422,523 - 22,483,672 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,470,837 - 22,531,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03523,906,713 - 23,968,034 (-)NCBIUU_Cfam_GSD_1.0
Gpld1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,793,902 - 2,841,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671782,135 - 827,771 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936671780,173 - 827,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,291,174 - 19,346,619 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,289,385 - 19,355,606 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,441,759 - 20,496,224 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPLD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,748,183 - 47,809,459 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,765,699 - 47,804,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604424,360,187 - 24,428,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpld1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,505,945 - 2,569,464 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247562,505,937 - 2,569,618 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpld1
216 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:151
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000024196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat

Markers in Region
RH131036  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21740,084,725 - 40,084,911 (+)MAPPERmRatBN7.2
Rnor_6.01742,085,137 - 42,085,322NCBIRnor6.0
Rnor_5.01743,952,934 - 43,953,119UniSTSRnor5.0
RGSC_v3.41747,145,677 - 47,145,862UniSTSRGSC3.4
Celera1739,722,321 - 39,722,506UniSTS
Cytogenetic Map17p11UniSTS
BI275110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21740,086,726 - 40,086,918 (+)MAPPERmRatBN7.2
Rnor_6.01742,087,138 - 42,087,329NCBIRnor6.0
Rnor_5.01743,954,935 - 43,955,126UniSTSRnor5.0
RGSC_v3.41747,147,678 - 47,147,869UniSTSRGSC3.4
Celera1739,724,322 - 39,724,513UniSTS
Cytogenetic Map17p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ308109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO393645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO571457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO571976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024196   ⟹   ENSRNOP00000024196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1740,084,617 - 40,126,939 (-)Ensembl
Rnor_6.0 Ensembl1742,085,028 - 42,127,678 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112554   ⟹   ENSRNOP00000079067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1740,085,261 - 40,126,939 (-)Ensembl
RefSeq Acc Id: NM_001100512   ⟹   NP_001093982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,554,975 (-)NCBI
mRatBN7.21740,084,616 - 40,126,939 (-)NCBI
Rnor_6.01742,085,027 - 42,127,678 (-)NCBI
Rnor_5.01743,952,824 - 44,000,859 (-)NCBI
RGSC_v3.41747,145,567 - 47,188,345 (-)RGD
Celera1739,722,211 - 39,764,466 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253926   ⟹   XP_006253988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,554,952 (-)NCBI
mRatBN7.21740,085,209 - 40,126,918 (-)NCBI
Rnor_6.01742,085,299 - 42,127,593 (-)NCBI
Rnor_5.01743,952,824 - 44,000,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771631   ⟹   XP_008769853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
mRatBN7.21740,084,620 - 40,132,034 (-)NCBI
Rnor_6.01742,085,031 - 42,130,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771635   ⟹   XP_008769857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
mRatBN7.21740,085,209 - 40,132,034 (-)NCBI
Rnor_6.01742,085,299 - 42,130,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600481   ⟹   XP_017455970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
mRatBN7.21740,084,620 - 40,132,034 (-)NCBI
Rnor_6.01742,085,031 - 42,130,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600483   ⟹   XP_017455972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
mRatBN7.21740,084,620 - 40,127,544 (-)NCBI
Rnor_6.01742,085,031 - 42,130,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600484   ⟹   XP_017455973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
mRatBN7.21740,084,620 - 40,132,034 (-)NCBI
Rnor_6.01742,085,031 - 42,130,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095513   ⟹   XP_038951441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,040 (-)NCBI
mRatBN7.21740,084,620 - 40,132,034 (-)NCBI
RefSeq Acc Id: XM_039095514   ⟹   XP_038951442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,040 (-)NCBI
mRatBN7.21740,084,620 - 40,132,034 (-)NCBI
RefSeq Acc Id: XM_063276185   ⟹   XP_063132255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,591 (-)NCBI
RefSeq Acc Id: XM_063276186   ⟹   XP_063132256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
RefSeq Acc Id: XM_063276187   ⟹   XP_063132257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,483 (-)NCBI
RefSeq Acc Id: XM_063276188   ⟹   XP_063132258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,483 (-)NCBI
RefSeq Acc Id: XM_063276189   ⟹   XP_063132259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
RefSeq Acc Id: XM_063276190   ⟹   XP_063132260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
RefSeq Acc Id: XM_063276191   ⟹   XP_063132261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,483 (-)NCBI
RefSeq Acc Id: XM_063276192   ⟹   XP_063132262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,558,506 (-)NCBI
RefSeq Acc Id: XM_063276193   ⟹   XP_063132263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,560,451 (-)NCBI
RefSeq Acc Id: XM_063276194   ⟹   XP_063132264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,512,659 - 40,554,952 (-)NCBI
RefSeq Acc Id: XR_005495254
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,518,348 - 40,558,506 (-)NCBI
mRatBN7.21740,090,307 - 40,132,035 (-)NCBI
RefSeq Acc Id: NP_001093982   ⟸   NM_001100512
- Peptide Label: precursor
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253988   ⟸   XM_006253926
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769853   ⟸   XM_008771631
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769857   ⟸   XM_008771635
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455973   ⟸   XM_017600484
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455972   ⟸   XM_017600483
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455970   ⟸   XM_017600481
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024196   ⟸   ENSRNOT00000024196
RefSeq Acc Id: XP_038951442   ⟸   XM_039095514
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951441   ⟸   XM_039095513
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   G3V8B1 (UniProtKB/TrEMBL),   A6KLE5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079067   ⟸   ENSRNOT00000112554
RefSeq Acc Id: XP_063132258   ⟸   XM_063276188
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   A6KLE5 (UniProtKB/TrEMBL),   G3V8B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132261   ⟸   XM_063276191
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132257   ⟸   XM_063276187
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   A6KLE5 (UniProtKB/TrEMBL),   G3V8B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132263   ⟸   XM_063276193
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132255   ⟸   XM_063276185
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   A6KLE5 (UniProtKB/TrEMBL),   G3V8B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132259   ⟸   XM_063276189
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132262   ⟸   XM_063276192
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132260   ⟸   XM_063276190
- Peptide Label: isoform X2
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132256   ⟸   XM_063276186
- Peptide Label: isoform X1
- UniProtKB: Q8R2H5 (UniProtKB/Swiss-Prot),   A6KLE5 (UniProtKB/TrEMBL),   G3V8B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132264   ⟸   XM_063276194
- Peptide Label: isoform X4
Protein Domains
Phospholipase C/D

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2H5-F1-model_v2 AlphaFold Q8R2H5 1-843 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700440
Promoter ID:EPDNEW_R10963
Type:initiation region
Name:Gpld1_1
Description:glycosylphosphatidylinositol specific phospholipase D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01742,127,700 - 42,127,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631371 AgrOrtholog
BioCyc Gene G2FUF-9427 BioCyc
Ensembl Genes ENSRNOG00000017702 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024196.4 UniProtKB/TrEMBL
  ENSRNOT00000112554.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprt_PLipase_D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPC/GPLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291132 ENTREZGENE
PANTHER GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn_dep_PLPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpld1 PhenoGen
PRINTS PHPHLIPASED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017702 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZM06_RAT UniProtKB/TrEMBL
  A6KLE5 ENTREZGENE, UniProtKB/TrEMBL
  G3V8B1 ENTREZGENE, UniProtKB/TrEMBL
  PHLD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Slc1a7  glycosylphosphatidylinositol specific phospholipase D1  Gpld1  glycosylphosphatidylinositol phospholipase D  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is decreased by insulin in diabetic animals 632912