Inhba (inhibin subunit beta A) - Rat Genome Database

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Gene: Inhba (inhibin subunit beta A) Rattus norvegicus
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Symbol: Inhba
Name: inhibin subunit beta A
RGD ID: 62074
Description: Predicted to enable identical protein binding activity; peptide hormone binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to decreased oxygen levels; and positive regulation of metabolic process. Located in extracellular space. Part of inhibin A complex. Biomarker of congestive heart failure; myocardial infarction; retinal degeneration; and rheumatic heart disease. Orthologous to human INHBA (inhibin subunit beta A); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin A; activin beta-A chain; inhibin beta A chain; inhibin beta A subunit; inhibin beta-A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81753,787,159 - 53,810,942 (-)NCBIGRCr8
mRatBN7.21749,091,635 - 49,111,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1752,294,696 - 52,307,755 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01756,297,581 - 56,310,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01750,395,401 - 50,408,458 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01751,894,869 - 51,919,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01749,961,222 - 49,985,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,244,466 - 57,257,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11757,247,306 - 57,260,372 (-)NCBI
Celera1745,163,387 - 45,176,397 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
InhbaRatBrain Hypoxia-Ischemia severityISOINHBA (Homo sapiens)329849106mRNA and protein:increased expression:umbilical cord blood (human)RGD 
InhbaRatBrain Hypoxia-Ischemia treatmentISOINHBA (Homo sapiens)329322882human construct in rat modelRGD 
InhbaRatBrain Hypoxia-Ischemia  IEP 329322882mRNA:increased expression:brain (rat)RGD 
InhbaRatcongestive heart failure  IEP 329849007protein:increased expression:heart (rat)RGD 
InhbaRatcongestive heart failure severityISOINHBA (Homo sapiens)1580888mRNA more ...RGD 
InhbaRatEndometrioid Carcinomas  ISOINHBA (Homo sapiens)2301688protein:decreased expression:endometriumRGD 
InhbaRatgestational diabetes  ISOINHBA (Homo sapiens)2313385protein:increased expression:serumRGD 
InhbaRatgestational diabetes  ISOINHBA (Homo sapiens)2313391protein:decreased expression:serumRGD 
InhbaRatmiddle cerebral artery infarction  ISOInhba (Mus musculus)329845521 RGD 
InhbaRatMycoplasma pneumoniae pneumonia severityISOINHBA (Homo sapiens)9068941 RGDPMID:28302172 and REF_RGD_ID:32716376
InhbaRatmyocardial infarction  ISOInhba (Mus musculus)329849118mRNA:increased expression:myocardium (mouse)RGD 
InhbaRatmyocardial infarction  IEP 1580888mRNA:increased expression:heart (rat)RGD 
InhbaRatMyocardial Reperfusion Injury  ISOInhba (Mus musculus)329849112mRNA and protein:increased expression:heart (mouse)RGD 
InhbaRatretinal degeneration  IEP 152025547associated with hyperaldosterone and mRNA:decreased expression:retina (rat)RGD 
InhbaRatRETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES  IEP 152025547associated with hyperaldosterone and mRNA:decreased expression:retina (rat)RGD 
InhbaRatrheumatic heart disease  IEP 155882558mRNA more ...RGD 
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Original Reference(s)
InhbaRatGreig cephalopolysyndactyly syndrome  ISOINHBA (Homo sapiens)8554872ClinVar Annotator: match by term: Greig cephalopolysyndactyly syndromeClinVarPMID:10441570 more ...
InhbaRatpleomorphic xanthoastrocytoma  ISOINHBA (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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Original Reference(s)
InhbaRatAcute Liver Failure  ISOINHBA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12560755
InhbaRatleiomyoma  ISOINHBA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22228119
InhbaRatpre-eclampsia  ISOINHBA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17332518
InhbaRatUterine Neoplasms  ISOINHBA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22228119

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Original Reference(s)
InhbaRat(1->4)-beta-D-glucan multiple interactionsISOInhba (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of INHBA mRNACTDPMID:36331819
InhbaRat(S)-amphetamine multiple interactionsISOInhba (Mus musculus)6480464SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of INHBA mRNA]CTDPMID:12205029
InhbaRat(S)-amphetamine increases expressionISOInhba (Mus musculus)6480464Dextroamphetamine results in increased expression of INHBA mRNACTDPMID:12205029 and PMID:12558987
InhbaRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
InhbaRat1-chloro-2,4-dinitrobenzene increases expressionISOInhba (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of INHBA mRNACTDPMID:19647056
InhbaRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of INHBA mRNACTDPMID:30723492
InhbaRat17alpha-ethynylestradiol affects expressionISOInhba (Mus musculus)6480464Ethinyl Estradiol affects the expression of INHBA mRNACTDPMID:17555576
InhbaRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of INHBA mRNACTDPMID:15834898 and PMID:28522409
InhbaRat17alpha-ethynylestradiol multiple interactionsISOInhba (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of INHBA mRNACTDPMID:17942748
InhbaRat17alpha-ethynylestradiol increases expressionISOInhba (Mus musculus)6480464Ethinyl Estradiol results in increased expression of INHBA mRNACTDPMID:17942748
InhbaRat17beta-estradiol multiple interactionsISOINHBA (Homo sapiens)64804644-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA] more ...CTDPMID:17636213 more ...
InhbaRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of INHBA mRNACTDPMID:35192832
InhbaRat17beta-estradiol increases expressionISOINHBA (Homo sapiens)6480464Estradiol results in increased expression of INHBA mRNACTDPMID:31614463
InhbaRat17beta-estradiol increases expressionISOInhba (Mus musculus)6480464Estradiol results in increased expression of INHBA mRNACTDPMID:22285243 and PMID:39298647
InhbaRat17beta-estradiol decreases expressionISOINHBA (Homo sapiens)6480464Estradiol results in decreased expression of INHBA mRNACTDPMID:21177794 and PMID:23373633
InhbaRat17beta-estradiol decreases expressionISOInhba (Mus musculus)6480464Estradiol results in decreased expression of INHBA mRNA and Estradiol results in decreased expression of INHBA proteinCTDPMID:17255206
InhbaRat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionISOINHBA (Homo sapiens)64804642 more ...CTDPMID:23146750 and PMID:38568856
InhbaRat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOINHBA (Homo sapiens)6480464[2 more ...CTDPMID:32653021
InhbaRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:23829299
InhbaRat2,3,7,8-tetrachlorodibenzodioxine increases secretionISOInhba (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased secretion of INHBA proteinCTDPMID:26572662

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Biological Process
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Original Reference(s)
InhbaRatactivin receptor signaling pathway involved_inISSUniProtKB:P084761600115GO_REF:0000024UniProtGO_REF:0000024
InhbaRatactivin receptor signaling pathway involved_inIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatactivin receptor signaling pathway involved_inISOINHBA (Homo sapiens)1624291 PMID:9884026RGDPMID:9884026
InhbaRatandrogen metabolic process acts_upstream_of_or_withinISOInhba (Mus musculus)1624291 PMID:32274496 and PMID:32954300RGDPMID:32274496 and PMID:32954300
InhbaRatandrogen metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q04998 and ensembl:ENSMUSP000000478941600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatandrost-4-ene-3,17-dione biosynthetic process acts_upstream_of_or_withinISOInhba (Mus musculus)1624291 PMID:32954300RGDPMID:32954300
InhbaRatandrost-4-ene-3,17-dione biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:Q04998 and ensembl:ENSMUSP000000478941600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatautophagy  IDA 329853763 RGD 
InhbaRatcardiac fibroblast cell development  IDA 151665478 RGD 
InhbaRatcellular response to angiotensin  IEP 151665478 RGD 
InhbaRatcellular response to cholesterol involved_inIDA 8554083PMID:19464342UniProt 
InhbaRatcellular response to follicle-stimulating hormone stimulus involved_inIDA 8554083PMID:19464342UniProt 
InhbaRatcellular response to hypoxia  IEP 329849112 RGD 
InhbaRatcellular response to oxygen-glucose deprivation  IEP 329853763protein:increased expression:neuronal PC12 cells ratRGD 
InhbaRatcytokine-mediated signaling pathway  IEP 1580888 RGD 
InhbaRatendodermal cell differentiation involved_inISOINHBA (Homo sapiens)1624291 PMID:21828274RGDPMID:21828274
InhbaRatendodermal cell differentiation involved_inIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatextrinsic apoptotic signaling pathway involved_inISOINHBA (Homo sapiens)1624291 PMID:9884026RGDPMID:9884026
InhbaRatextrinsic apoptotic signaling pathway involved_inIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRateyelid development in camera-type eye involved_inISSUniProtKB:Q049981600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Original Reference(s)
InhbaRatactivin A complex part_ofISOINHBA (Homo sapiens)1624291 PMID:12660162 and PMID:7890768RGDPMID:12660162 and PMID:7890768
InhbaRatactivin A complex part_ofIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatactivin A complex part_ofISSUniProtKB:P084761600115GO_REF:0000024UniProtGO_REF:0000024
InhbaRatenzyme activator complex part_ofISOINHBA (Homo sapiens)1624291 PMID:12660162RGDPMID:12660162
InhbaRatenzyme activator complex part_ofIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatextracellular region located_inISOINHBA (Homo sapiens)1624291 PMID:12213882RGDPMID:12213882
InhbaRatextracellular region located_inIEAInterPro:IPR000491 and InterPro:IPR0156151600115GO_REF:0000002InterProGO_REF:0000002
InhbaRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
InhbaRatextracellular region located_inIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
InhbaRatextracellular region located_inISSUniProtKB:P084761600115GO_REF:0000024UniProtGO_REF:0000024
InhbaRatextracellular space  IDA 9743910 RGD 
InhbaRatextracellular space is_active_inIBAFB:FBgn0000490 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
InhbaRatinhibin A complex  IDA 2290410 RGD 
InhbaRatinhibin A complex part_ofISOINHBA (Homo sapiens)1624291 PMID:10746731 and PMID:7890768RGDPMID:10746731 and PMID:7890768
InhbaRatinhibin A complex part_ofIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatperinuclear region of cytoplasm located_inISOInhba (Mus musculus)1624291 PMID:8133077RGDPMID:8133077
InhbaRatperinuclear region of cytoplasm located_inIEAUniProtKB:Q04998 and ensembl:ENSMUSP000000478941600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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InhbaRatcytokine activity enablesISOINHBA (Homo sapiens)1624291 PMID:9884026RGDPMID:9884026
InhbaRatcytokine activity enablesIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatcytokine activity enablesIBAMGI:1346047 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
InhbaRatcytokine activity enablesISSUniProtKB:P084761600115GO_REF:0000024UniProtGO_REF:0000024
InhbaRatgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
InhbaRatgrowth factor activity enablesIEAInterPro:IPR001839 and InterPro:IPR0179481600115GO_REF:0000002InterProGO_REF:0000002
InhbaRathormone activity enablesIEAUniProtKB-KW:KW-03721600115GO_REF:0000043UniProtGO_REF:0000043
InhbaRathormone activity enablesIEAInterPro:IPR0004911600115GO_REF:0000002InterProGO_REF:0000002
InhbaRatidentical protein binding enablesISOINHBA (Homo sapiens)1624291UniProtKB:P08476 and PMID:2575216RGDPMID:2575216
InhbaRatidentical protein binding enablesIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatpeptide hormone binding enablesISOINHBA (Homo sapiens)1624291UniProtKB:P19883 and PMID:16198295RGDPMID:16198295
InhbaRatpeptide hormone binding enablesIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRatprotein binding enablesISOINHBA (Homo sapiens)1624291UniProtKB:O95633 more ...RGDPMID:12697670 more ...
InhbaRatprotein-containing complex binding  IDA 2290410heterodimerizationRGD 
InhbaRatsignaling receptor binding enablesISOInhba (Mus musculus)1624291PR:P37172 more ...RGDPMID:1646080 and PMID:7577669
InhbaRatsignaling receptor binding enablesIEAUniProtKB:Q04998 and ensembl:ENSMUSP000000478941600115GO_REF:0000107EnsemblGO_REF:0000107
InhbaRattype II activin receptor binding enablesISOINHBA (Homo sapiens)1624291UniProtKB:P27038 more ...RGDPMID:7890768
InhbaRattype II activin receptor binding enablesIEAUniProtKB:P08476 and ensembl:ENSP000002422081600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - KEGG (archival)

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Original Reference(s)
InhbaRattransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGrno:04350

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#
Reference Title
Reference Citation
1. Regulation of inhibin/activin expression in rat early antral follicles. Andreone L, etal., Mol Cell Endocrinol. 2009 Oct 15;309(1-2):48-54. doi: 10.1016/j.mce.2009.05.003. Epub 2009 May 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Hu J, etal., Eur J Pharmacol. 2016 Oct 15;789:319-327. doi: 10.1016/j.ejphar.2016.07.053. Epub 2016 Jul 29.
5. Cytokine modulation of inhibin secretion in cultured rat granulosa cells. Imai M, etal., J Endocrinol. 1996 Dec;151(3):449-57.
6. Downstream mRNA Target Analysis in Neonatal Hypoxic-Ischaemic Encephalopathy Identifies Novel Marker of Severe Injury: a Proof of Concept Paper. Looney AM, etal., Mol Neurobiol. 2017 Dec;54(10):8420-8428. doi: 10.1007/s12035-016-0330-4. Epub 2016 Dec 12.
7. Involvement of Pax-2 in the action of activin A on tubular cell regeneration. Maeshima A, etal., J Am Soc Nephrol 2002 Dec;13(12):2850-9.
8. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
9. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. McTavish KJ, etal., Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64. doi: 10.1016/j.mce.2013.03.021. Epub 2013 Apr 6.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibin/activin subunits beta-A (-betaA) and beta-B (-betaB) are differentially localised in normal, hyperplastic and malignant human endometrial tissue. Mylonas I, etal., Acta Histochem. 2006;108(1):1-11. Epub 2006 Jan 19.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
14. Abnormal concentration of maternal serum activin-A in gestational diseases. Petraglia F, etal., J Clin Endocrinol Metab. 1995 Feb;80(2):558-61.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Predicting complications of pregnancy with first-trimester maternal serum free-betahCG, PAPP-A and inhibin-A. Tul N, etal., Prenat Diagn. 2003 Dec 15;23(12):990-6.
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PMID:1310063   PMID:1646080   PMID:2575216   PMID:7577669   PMID:7799920   PMID:7890768   PMID:8133077   PMID:8267637   PMID:9032295   PMID:9239411   PMID:9884026   PMID:10391928  
PMID:10932194   PMID:11948405   PMID:12213882   PMID:12681448   PMID:12702211   PMID:12737440   PMID:12761253   PMID:12782410   PMID:14551263   PMID:15031321   PMID:15070852   PMID:15236469  
PMID:15451575   PMID:15673690   PMID:15821113   PMID:16198295   PMID:16601134   PMID:16935389   PMID:17344471   PMID:17609433   PMID:17680997   PMID:18239071   PMID:18597229   PMID:18781389  
PMID:19029909   PMID:19292055   PMID:19298640   PMID:19524137   PMID:19736306   PMID:19782349   PMID:20573232   PMID:21147108   PMID:21256182   PMID:21281489   PMID:21828274   PMID:22106407  
PMID:23812417   PMID:23831638   PMID:24006456   PMID:24141247   PMID:24299059   PMID:24883308   PMID:25804741   PMID:26721511   PMID:27693962   PMID:27769859   PMID:29113826   PMID:29187373  
PMID:32133888  



Inhba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81753,787,159 - 53,810,942 (-)NCBIGRCr8
mRatBN7.21749,091,635 - 49,111,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1752,294,696 - 52,307,755 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01756,297,581 - 56,310,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01750,395,401 - 50,408,458 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01751,894,869 - 51,919,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01749,961,222 - 49,985,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,244,466 - 57,257,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11757,247,306 - 57,260,372 (-)NCBI
Celera1745,163,387 - 45,176,397 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
INHBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38741,685,114 - 41,705,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl741,667,168 - 41,705,834 (-)EnsemblGRCh38hg38GRCh38
GRCh37741,724,712 - 41,742,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36741,695,126 - 41,709,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 34741,502,035 - 41,513,299NCBI
Celera741,719,390 - 41,733,490 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef741,613,504 - 41,627,622 (-)NCBIHuRef
CHM1_1741,731,917 - 41,746,019 (-)NCBICHM1_1
T2T-CHM13v2.0741,843,512 - 41,867,440 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2741,768,467 - 41,782,571 (-)NCBI
Inhba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391316,178,841 - 16,206,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1316,186,436 - 16,206,206 (+)EnsemblGRCm39 Ensembl
GRCm381316,004,256 - 16,031,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1316,011,851 - 16,031,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv371316,106,308 - 16,119,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361315,805,362 - 15,818,098 (+)NCBIMGSCv36mm8
Celera1316,301,736 - 16,314,777 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.85NCBI
Inhba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554602,046,588 - 2,066,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554602,054,879 - 2,066,628 (+)NCBIChiLan1.0ChiLan1.0
INHBA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2646,734,760 - 46,755,426 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1795,059,503 - 95,080,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0742,538,591 - 42,556,578 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1742,580,730 - 42,598,712 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl742,580,730 - 42,595,097 (+)Ensemblpanpan1.1panPan2
INHBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,272,978 - 8,288,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,272,872 - 8,283,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,122,697 - 8,138,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,321,520 - 8,336,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,318,003 - 8,332,480 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,301,757 - 8,317,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,269,907 - 8,285,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,385,256 - 8,400,687 (+)NCBIUU_Cfam_GSD_1.0
Inhba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511897,666,669 - 97,672,334 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647816,878,725 - 16,884,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1852,889,684 - 52,900,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,115,379 - 53,117,128 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11852,889,684 - 52,909,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21857,997,858 - 58,017,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21255,481,493 - 55,483,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
INHBA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12116,936,054 - 16,951,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2116,936,175 - 16,946,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660625,522,195 - 5,540,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inhba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474019,464,289 - 19,482,888 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474019,458,835 - 19,482,570 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Inhba
100 total Variants

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000019272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 50 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat

1 to 10 of 50 rows
INHBA-STS  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21749,096,032 - 49,096,354 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,267 - 51,899,588NCBIRnor6.0
Rnor_5.01749,965,620 - 49,965,941UniSTSRnor5.0
RGSC_v3.41757,244,587 - 57,244,908UniSTSRGSC3.4
Celera1745,163,508 - 45,163,829UniSTS
Cytogenetic Map17q12.1UniSTS
UniSTS:143589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21749,096,024 - 49,096,369 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,259 - 51,899,603NCBIRnor6.0
Rnor_5.01749,965,612 - 49,965,956UniSTSRnor5.0
RGSC_v3.41757,244,579 - 57,244,923UniSTSRGSC3.4
Celera1745,163,500 - 45,163,844UniSTS
Cytogenetic Map17q12.1UniSTS
UniSTS:496691  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81753,791,517 - 53,791,731 (+)Marker Load Pipeline
mRatBN7.21749,095,992 - 49,096,207 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,227 - 51,899,441NCBIRnor6.0
Rnor_5.01749,965,580 - 49,965,794UniSTSRnor5.0
RGSC_v3.41757,244,547 - 57,244,761UniSTSRGSC3.4
Celera1745,163,468 - 45,163,682UniSTS
Cytogenetic Map17q12.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31



Ensembl Acc Id: ENSRNOT00000019272   ⟹   ENSRNOP00000019272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)Ensembl
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)Ensembl
RefSeq Acc Id: NM_017128   ⟹   NP_058824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81753,791,436 - 53,804,508 (-)NCBI
mRatBN7.21749,095,912 - 49,108,982 (-)NCBI
Rnor_6.01751,899,146 - 51,912,423 (-)NCBI
Rnor_5.01749,961,222 - 49,985,653 (-)NCBI
RGSC_v3.41757,244,466 - 57,257,531 (-)RGD
Celera1745,163,387 - 45,176,397 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254001   ⟹   XP_006254063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81753,787,159 - 53,809,889 (-)NCBI
mRatBN7.21749,091,635 - 49,111,573 (-)NCBI
Rnor_6.01751,894,869 - 51,918,092 (-)NCBI
Rnor_5.01749,961,222 - 49,985,653 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771712   ⟹   XP_008769934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81753,787,159 - 53,809,890 (-)NCBI
mRatBN7.21749,091,635 - 49,111,204 (-)NCBI
Rnor_6.01751,894,869 - 51,918,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276286   ⟹   XP_063132356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81753,787,159 - 53,810,942 (-)NCBI
RefSeq Acc Id: XM_063276287   ⟹   XP_063132357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81753,787,159 - 53,809,890 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_058824 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254063 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769934 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132356 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132357 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41436 (Get FASTA)   NCBI Sequence Viewer  
  EDL87403 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019272
  ENSRNOP00000019272.2
GenBank Protein P18331 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_058824   ⟸   NM_017128
- Peptide Label: preproprotein
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254063   ⟸   XM_006254001
- Peptide Label: isoform X1
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769934   ⟸   XM_008771712
- Peptide Label: isoform X1
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019272   ⟸   ENSRNOT00000019272
RefSeq Acc Id: XP_063132356   ⟸   XM_063276286
- Peptide Label: isoform X1
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
TGF-beta family profile

Name Modeler Protein Id AA Range Protein Structure
AF-P18331-F1-model_v2 AlphaFold P18331 1-424 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700511
Promoter ID:EPDNEW_R11033
Type:initiation region
Name:Inhba_1
Description:inhibin beta A subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01751,912,433 - 51,912,493EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9095 BioCyc
Ensembl Genes ENSRNOG00000014320 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019272 ENTREZGENE
  ENSRNOT00000019272.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Inhibin_betaA UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:29200 UniProtKB/Swiss-Prot
NCBI Gene 29200 ENTREZGENE
PANTHER INHIBIN BETA A CHAIN UniProtKB/Swiss-Prot
  PTHR11848 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Inhba PhenoGen
PRINTS INHIBINBA UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014320 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC221252
UniProt A6K9B0 ENTREZGENE, UniProtKB/TrEMBL
  INHBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inhba  inhibin subunit beta A  Inhba  inhibin beta A subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inhba  inhibin beta A subunit  Inhba  inhibin beta-A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inhba  inhibin beta-A      Name updated 70584 APPROVED

Note Type Note Reference
gene_physical_interaction interacts with beta B subunit to produce heterodimer which inhibits secretion of FSH from pituitary gonadotrophs 61638
gene_regulation expression is stimulated by FSH 61638