RGD Reference Report - Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat. - Rat Genome Database

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Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat.

Authors: Yeh, J  Kim, B 
Citation: Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
RGD ID: 9743910
Pubmed: PMID:17636211   (View Abstract at PubMed)
DOI: DOI:10.1177/1933719106298186   (Journal Full-text)

Reproductive aging results in declines in female fertility and in slight declines in baseline serum inhibins in humans. The authors tested the hypothesis that exogenous ovarian stimulation as a noninvasive dynamic test, by amplifying inhibin levels, can define more accurately than baseline serum inhibin levels the ovarian age of female rats. Female rats--young (immature, 26 days old), adult (65-75 days old), and reproductively aged (8- to 9-month-old retired breeders)--were administered pregnant mare's serum gonadotropin to stimulate the ovaries and the serum inhibin A and inhibin B, and ovarian inhibins were measured. The young and adult females had at least a 4- to 10-fold increase in serum inhibin A and inhibin B after ovarian stimulation, but the reproductively aged females did not. Adult female serum inhibin measurements after stimulation at every stage of the estrous cycle revealed a consistent 4- to 5-fold increase in all stages, whereas the reproductively aged females did not. Western blot analyses of ovarian lysates were consistent with the serum inhibin level results and revealed that ovarian inhibin alpha, inhibin beta A, and inhibin beta B subunit levels in adult ovaries were elevated after ovarian stimulation but not in the reproductively aged ovaries. The data presented here demonstrate that young, adult, and reproductively aged female inhibin responses after exogenous ovarian stimulation were different. Inhibin measurement in serum after ovarian challenge in rats, therefore, is a noninvasive method that could be used to dissect ovarian function in aging in more detail.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to gonadotropin  IEP 9743910 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space  IDA 9743910; 9743910 RGD 
inhibin B complex  IDA 9743910 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
inhibin binding  IPIInhbb (Rattus norvegicus)9743910 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Inha  (inhibin subunit alpha)
Inhba  (inhibin subunit beta A)
Inhbb  (inhibin subunit beta B)


Additional Information