Inhba (inhibin subunit beta A) - Rat Genome Database

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Gene: Inhba (inhibin subunit beta A) Chinchilla lanigera
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Symbol: Inhba
Name: inhibin subunit beta A
RGD ID: 9052895
Description: ENCODES a protein that exhibits cytokine activity (ortholog); identical protein binding (ortholog); peptide hormone binding (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); androgen metabolic process (ortholog); androst-4-ene-3,17-dione biosynthetic process (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Brain Hypoxia-Ischemia (ortholog); congestive heart failure (ortholog); FOUND IN activin A complex (ortholog); enzyme activator complex (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inhibin beta A chain; inhibin beta A subunit; inhibin, beta A
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554602,046,588 - 2,066,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554602,054,879 - 2,066,628 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO)
androgen metabolic process  (ISO)
androst-4-ene-3,17-dione biosynthetic process  (ISO)
autophagy  (ISO)
cardiac fibroblast cell development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to cholesterol  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
cytokine-mediated signaling pathway  (ISO)
endodermal cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
eyelid development in camera-type eye  (ISO)
GABAergic neuron differentiation  (ISO)
gene expression  (ISO)
hair follicle development  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hemoglobin biosynthetic process  (ISO)
lipid metabolic process  (ISO)
male gonad development  (ISO)
mesoderm formation  (ISO)
mesodermal cell differentiation  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of hair follicle development  (ISO)
odontogenesis  (ISO)
ovarian follicle development  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of ovulation  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase III  (ISO)
progesterone secretion  (ISO)
regulation of follicle-stimulating hormone secretion  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to aldosterone  (ISO)
roof of mouth development  (ISO)
Sertoli cell differentiation  (ISO)
SMAD protein signal transduction  (ISO)
steroid biosynthetic process  (ISO)
steroid metabolic process  (ISO)
striatal medium spiny neuron differentiation  (ISO)
testosterone biosynthetic process  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Inhba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554602,046,588 - 2,066,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554602,054,879 - 2,066,628 (+)NCBIChiLan1.0ChiLan1.0
INHBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38741,685,114 - 41,705,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl741,667,168 - 41,705,834 (-)EnsemblGRCh38hg38GRCh38
GRCh37741,724,712 - 41,742,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36741,695,126 - 41,709,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 34741,502,035 - 41,513,299NCBI
Celera741,719,390 - 41,733,490 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef741,613,504 - 41,627,622 (-)NCBIHuRef
CHM1_1741,731,917 - 41,746,019 (-)NCBICHM1_1
T2T-CHM13v2.0741,843,512 - 41,867,440 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2741,768,467 - 41,782,571 (-)NCBI
Inhba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391316,178,841 - 16,206,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1316,186,436 - 16,206,206 (+)EnsemblGRCm39 Ensembl
GRCm381316,004,256 - 16,031,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1316,011,851 - 16,031,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv371316,106,308 - 16,119,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361315,805,362 - 15,818,098 (+)NCBIMGSCv36mm8
Celera1316,301,736 - 16,314,777 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.85NCBI
Inhba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81753,787,159 - 53,810,942 (-)NCBIGRCr8
mRatBN7.21749,091,635 - 49,111,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1752,294,696 - 52,307,755 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01756,297,581 - 56,310,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01750,395,401 - 50,408,458 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01751,894,869 - 51,919,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01749,961,222 - 49,985,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,244,466 - 57,257,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11757,247,306 - 57,260,372 (-)NCBI
Celera1745,163,387 - 45,176,397 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
INHBA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2646,734,760 - 46,755,426 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1795,059,503 - 95,080,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0742,538,591 - 42,556,578 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1742,580,730 - 42,598,712 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl742,580,730 - 42,595,097 (+)Ensemblpanpan1.1panPan2
INHBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,272,978 - 8,288,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,272,872 - 8,283,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,122,697 - 8,138,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,321,520 - 8,336,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,318,003 - 8,332,480 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,301,757 - 8,317,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,269,907 - 8,285,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,385,256 - 8,400,687 (+)NCBIUU_Cfam_GSD_1.0
Inhba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511897,666,669 - 97,672,334 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647816,878,725 - 16,884,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1852,889,684 - 52,900,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,115,379 - 53,117,128 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11852,889,684 - 52,909,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21857,997,858 - 58,017,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21255,481,493 - 55,483,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
INHBA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12116,936,054 - 16,951,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2116,936,175 - 16,946,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660625,522,195 - 5,540,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inhba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474019,464,289 - 19,482,888 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474019,458,835 - 19,482,570 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000010539   ⟹   ENSCLAP00000010409
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554602,046,588 - 2,066,609 (+)Ensembl
RefSeq Acc Id: XM_005397723   ⟹   XP_005397780
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554602,054,879 - 2,066,628 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005397780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010409
  ENSCLAP00000010409.1
RefSeq Acc Id: XP_005397780   ⟸   XM_005397723
- UniProtKB: A0A8C2V8K9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000010409   ⟸   ENSCLAT00000010539
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007192 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010539 ENTREZGENE
  ENSCLAT00000010539.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Inhibin_betaA UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Inhba ENTREZGENE
PANTHER INHIBIN BETA A CHAIN UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PRINTS INHIBINBA UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C2V8K9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Inhba  inhibin subunit beta A    inhibin beta A subunit  Symbol and/or name change 5135510 APPROVED
2016-08-03 Inhba  inhibin beta A subunit    inhibin, beta A  Symbol and/or name change 5135510 APPROVED