Sfrp4 (secreted frizzled-related protein 4) - Rat Genome Database

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Gene: Sfrp4 (secreted frizzled-related protein 4) Rattus norvegicus
Symbol: Sfrp4
Name: secreted frizzled-related protein 4
RGD ID: 621075
Description: Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DDC-4 protein; frizzled related protein; frizzled-related protein; FRP; sFRP-4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21745,278,867 - 45,330,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1747,396,966 - 47,407,220 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,156,129 - 52,166,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,646,527 - 46,656,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,383,983 - 47,394,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01756,095,166 - 56,105,248 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,121,425 - 53,131,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,124,265 - 53,134,348 (-)NCBI
Celera1751,198,532 - 51,208,589 (+)NCBICelera
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
biguanides  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buserelin  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclothiazide  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
finasteride  (EXP)
fonofos  (ISO)
formaldehyde  (EXP)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
linsidomine  (EXP)
methylarsonic acid  (ISO)
mitoxantrone  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perindopril  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
terbufos  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function
protein binding  (ISO)
Wnt-protein binding  (IBA,IEA,IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. Berndt T, etal., J Clin Invest. 2003 Sep;112(5):785-94.
2. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
4. Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy. Fujita M, etal., J Mol Endocrinol 2002 Jun;28(3):213-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction. Hewitt DP, etal., Biol Reprod. 2006 Jul;75(1):75-81. Epub 2006 Mar 15.
7. Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. Hsieh M, etal., Endocrinology. 2003 Oct;144(10):4597-606. Epub 2003 Jul 10.
8. Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury. Matsushima K, etal., Tissue Eng Part A. 2010 Jun 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. Wolf V, etal., FEBS Lett. 1997 Nov 17;417(3):385-9.
15. Transcriptional activity of the promoter region of rat frizzled-related protein gene. Yam JW, etal., Biochem Biophys Res Commun 2001 Aug 10;286(1):94-100.
Additional References at PubMed
PMID:9510961   PMID:11793365   PMID:12815282   PMID:14760084   PMID:15705870   PMID:16151791   PMID:17462603   PMID:18166153   PMID:18452624   PMID:18938133   PMID:18945944   PMID:21120994  
PMID:23200852   PMID:27355534   PMID:33726573  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21745,278,867 - 45,330,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1747,396,966 - 47,407,220 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,156,129 - 52,166,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,646,527 - 46,656,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,383,983 - 47,394,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01756,095,166 - 56,105,248 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,121,425 - 53,131,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,124,265 - 53,134,348 (-)NCBI
Celera1751,198,532 - 51,208,589 (+)NCBICelera
Cytogenetic Map17q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38737,905,932 - 37,916,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl737,905,932 - 38,025,695 (-)EnsemblGRCh38hg38GRCh38
GRCh37737,945,534 - 37,956,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36737,912,068 - 37,922,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34737,718,782 - 37,729,617NCBI
Celera737,930,244 - 37,941,234 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef737,825,879 - 37,836,854 (-)NCBIHuRef
CHM1_1737,945,489 - 37,956,481 (-)NCBICHM1_1
T2T-CHM13v2.0738,046,940 - 38,057,852 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2737,983,430 - 37,994,420 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391319,807,345 - 19,816,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,807,274 - 19,817,164 (+)EnsemblGRCm39 Ensembl
GRCm381319,623,175 - 19,632,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1319,623,104 - 19,632,994 (+)EnsemblGRCm38mm10GRCm38
MGSCv371319,715,044 - 19,724,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361319,630,648 - 19,640,286 (+)NCBIMGSCv36mm8
MGSCv361319,028,703 - 19,038,341 (+)NCBIMGSCv36mm8
Cytogenetic Map13A2NCBI
cM Map136.99NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554605,654,288 - 5,664,219 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554605,654,187 - 5,666,475 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1791,061,073 - 91,072,628 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0738,542,105 - 38,553,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1738,764,146 - 38,774,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl738,764,146 - 38,774,264 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11812,018,049 - 12,028,123 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,017,978 - 12,027,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1811,662,597 - 11,672,449 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01812,289,459 - 12,299,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,289,459 - 12,298,908 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,106,943 - 12,116,697 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,027,094 - 12,036,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,254,578 - 12,264,365 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511894,045,401 - 94,055,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,257,801 - 13,266,701 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,257,183 - 13,266,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9108,404,040 - 108,414,307 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19108,404,314 - 108,414,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12120,601,281 - 20,611,273 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2120,601,396 - 20,612,138 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660621,730,598 - 1,741,385 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474023,334,060 - 23,344,124 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474023,333,493 - 23,345,970 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sfrp4
215 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:80
Interacting mature miRNAs:93
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,332,057 - 45,332,213 (+)MAPPERmRatBN7.2
Rnor_6.01747,395,650 - 47,395,805NCBIRnor6.0
Rnor_5.01756,093,426 - 56,093,581UniSTSRnor5.0
RGSC_v3.41753,133,092 - 53,133,247UniSTSRGSC3.4
Celera1751,196,792 - 51,196,947UniSTS
Cytogenetic Map17q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,319,946 - 45,320,145 (+)MAPPERmRatBN7.2
Rnor_6.01747,383,542 - 47,383,740NCBIRnor6.0
Rnor_5.01756,105,491 - 56,105,689UniSTSRnor5.0
RGSC_v3.41753,120,984 - 53,121,182UniSTSRGSC3.4
Celera1751,208,832 - 51,209,030UniSTS
Cytogenetic Map17q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,320,707 - 45,320,916 (+)MAPPERmRatBN7.2
Rnor_6.01747,384,303 - 47,384,511NCBIRnor6.0
Rnor_5.01756,104,720 - 56,104,928UniSTSRnor5.0
RGSC_v3.41753,121,745 - 53,121,953UniSTSRGSC3.4
Celera1751,208,061 - 51,208,269UniSTS
Cytogenetic Map17q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 1 1 10 1
Low 22 36 22 18 22 7 10 44 18 23 8 7
Below cutoff 3 21 12 11 1 11 30 17 8 3


RefSeq Acc Id: ENSRNOT00000079216   ⟹   ENSRNOP00000069552
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)Ensembl
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079368   ⟹   ENSRNOP00000075046
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,319,764 - 45,330,727 (-)Ensembl
Rnor_6.0 Ensembl1747,383,246 - 47,394,231 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110718   ⟹   ENSRNOP00000094074
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,322,299 - 45,330,736 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119265   ⟹   ENSRNOP00000084490
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,279,101 - 45,330,736 (-)Ensembl
RefSeq Acc Id: NM_053544   ⟹   NP_445996
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21745,320,388 - 45,330,639 (-)NCBI
Rnor_6.01747,383,983 - 47,394,065 (-)NCBI
Rnor_5.01756,095,166 - 56,105,248 (+)NCBI
RGSC_v3.41753,121,425 - 53,131,507 (-)RGD
Celera1751,198,532 - 51,208,589 (+)RGD
RefSeq Acc Id: XM_039096132   ⟹   XP_038952060
Rat AssemblyChrPosition (strand)Source
mRatBN7.21745,278,867 - 45,330,806 (-)NCBI
RefSeq Acc Id: XM_039096133   ⟹   XP_038952061
Rat AssemblyChrPosition (strand)Source
mRatBN7.21745,319,697 - 45,329,017 (-)NCBI
RefSeq Acc Id: NP_445996   ⟸   NM_053544
- Peptide Label: precursor
- UniProtKB: A6KN49 (UniProtKB/TrEMBL),   G3V8G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075046   ⟸   ENSRNOT00000079368
RefSeq Acc Id: ENSRNOP00000069552   ⟸   ENSRNOT00000079216
RefSeq Acc Id: XP_038952060   ⟸   XM_039096132
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952061   ⟸   XM_039096133
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000094074   ⟸   ENSRNOT00000110718
RefSeq Acc Id: ENSRNOP00000084490   ⟸   ENSRNOT00000119265
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLS4-F1-model_v2 AlphaFold Q9JLS4 1-348 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700500
Promoter ID:EPDNEW_R11024
Type:single initiation site
Description:secreted frizzled-related protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01747,394,239 - 47,394,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621075 AgrOrtholog
BioCyc Gene G2FUF-9147 BioCyc
Ensembl Genes ENSRNOG00000054957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079216.2 UniProtKB/TrEMBL
  ENSRNOT00000079368.2 UniProtKB/TrEMBL
  ENSRNOT00000110718.1 UniProtKB/TrEMBL
  ENSRNOT00000119265.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89803 UniProtKB/Swiss-Prot
PANTHER PTHR11309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11309:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sfrp4 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054957 RatGTEx
SMART C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q9JLS4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35222 UniProtKB/Swiss-Prot
  Q9JLS5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Sfrp4  secreted frizzled-related protein 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sfrp4  secreted frizzled-related protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is up-regulated after estrogen treatment in the the pregnant uterus 633927