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Gene: Sfrp4 (secreted frizzled-related protein 4) Rattus norvegicus
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Symbol: Sfrp4
Name: secreted frizzled-related protein 4
Description: Exhibits Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Localizes to the cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DDC-4 protein; frizzled related protein; frizzled-related protein; FRP; sFRP-4
Orthologs:
Homo sapiens (human) : SFRP4 (secreted frizzled related protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Sfrp4 (secreted frizzled-related protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sfrp4 (secreted frizzled related protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SFRP4 (secreted frizzled related protein 4)
Canis lupus familiaris (dog) : SFRP4 (secreted frizzled related protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sfrp4 (secreted frizzled related protein 4)
Sus scrofa (pig) : SFRP4 (secreted frizzled related protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01747,383,983 - 47,394,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01756,095,166 - 56,105,248 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,121,425 - 53,131,507 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11753,124,265 - 53,134,348 (-)NCBI
Celera1751,198,532 - 51,208,589 (+)NCBICelera
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sfrp4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621075
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.