RGD Reference Report - Secreted and transmembrane wnt inhibitors and activators. - Rat Genome Database

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Secreted and transmembrane wnt inhibitors and activators.

Authors: Cruciat, CM  Niehrs, C 
Citation: Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
RGD ID: 7365107
Pubmed: PMID:23085770   (View Abstract at PubMed)
PMCID: PMC3578365   (View Article at PubMed Central)
DOI: DOI:10.1101/cshperspect.a015081   (Journal Full-text)

Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic development and adult homeostasis. Wnt signaling is modulated by a number of evolutionarily conserved inhibitors and activators. Wnt inhibitors belong to small protein families, including sFRP, Dkk, WIF, Wise/SOST, Cerberus, IGFBP, Shisa, Waif1, APCDD1, and Tiki1. Their common feature is to antagonize Wnt signaling by preventing ligand-receptor interactions or Wnt receptor maturation. Conversely, the Wnt activators, R-spondin and Norrin, promote Wnt signaling by binding to Wnt receptors or releasing a Wnt-inhibitory step. With few exceptions, these antagonists and agonists are not pure Wnt modulators, but also affect additional signaling pathways, such as TGF-beta and FGF signaling. Here we discuss their interactions with Wnt ligands and Wnt receptors, their role in developmental processes, as well as their implication in disease.

Objects Annotated

Genes (Rattus norvegicus)
Frzb  (frizzled-related protein)
Lgr4  (leucine-rich repeat-containing G protein-coupled receptor 4)
Lgr5  (leucine rich repeat containing G protein coupled receptor 5)
Ndp  (norrin cystine knot growth factor NDP)
Sfrp1  (secreted frizzled-related protein 1)
Sfrp2  (secreted frizzled-related protein 2)
Sfrp4  (secreted frizzled-related protein 4)
Sfrp5  (secreted frizzled-related protein 5)
Sost  (sclerostin)
Sostdc1  (sclerostin domain containing 1)

Genes (Mus musculus)
Frzb  (frizzled-related protein)
Lgr4  (leucine-rich repeat-containing G protein-coupled receptor 4)
Lgr5  (leucine rich repeat containing G protein coupled receptor 5)
Ndp  (Norrie disease (pseudoglioma) (human))
Sfrp1  (secreted frizzled-related protein 1)
Sfrp2  (secreted frizzled-related protein 2)
Sfrp4  (secreted frizzled-related protein 4)
Sfrp5  (secreted frizzled-related sequence protein 5)
Sost  (sclerostin)
Sostdc1  (sclerostin domain containing 1)

Genes (Homo sapiens)
FRZB  (frizzled related protein)
LGR4  (leucine rich repeat containing G protein-coupled receptor 4)
LGR5  (leucine rich repeat containing G protein-coupled receptor 5)
NDP  (norrin cystine knot growth factor NDP)
SFRP1  (secreted frizzled related protein 1)
SFRP2  (secreted frizzled related protein 2)
SFRP4  (secreted frizzled related protein 4)
SFRP5  (secreted frizzled related protein 5)
SOST  (sclerostin)
SOSTDC1  (sclerostin domain containing 1)


Additional Information