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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621075
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sfrp4
Name: secreted frizzled-related protein 4
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfrp4decreases expressionISOSfrp4 (Mus musculus)6480464CTDarsenite results in decreased expression of SFRP4 mRNAPMID:15894712
Sfrp4increases expressionISOSfrp4 (Mus musculus)6480464CTDarsenite results in increased expression of SFRP4 mRNAPMID:18929588
Sfrp4multiple interactionsISOSfrp4 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SFRP4 mRNA; TRP53 protein affects the reaction [arsenite results in increased expression of SFRP4 mRNA]PMID:15894712 PMID:18929588
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