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Gene: Gli3 (GLI family zinc finger 3) Rattus norvegicus
Symbol: Gli3
Name: GLI family zinc finger 3
Description: Predicted to have several functions, including beta-catenin binding activity; enzyme binding activity; and mediator complex binding activity. Involved in gland development; response to estrogen; and wound healing. Localizes to cytoplasm and nucleus. Biomarker of clubfoot and hypospadias. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GLI-Kruppel family member GLI3; GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome); LOC307001; transcriptional activator GLI3
Homo sapiens (human) : GLI3 (GLI family zinc finger 3)  HGNC  Alliance
Mus musculus (house mouse) : Gli3 (GLI-Kruppel family member GLI3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli3 (GLI family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI3 (GLI family zinc finger 3)
Canis lupus familiaris (dog) : GLI3 (GLI family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli3 (GLI family zinc finger 3)
Sus scrofa (pig) : GLI3 (GLI family zinc finger 3)
Chlorocebus sabaeus (African green monkey) : GLI3 (GLI family zinc finger 3)
Heterocephalus glaber (naked mole-rat) : Gli3 (GLI family zinc finger 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01752,294,942 - 52,569,036 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1752,294,942 - 52,569,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01750,360,049 - 50,629,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,594,102 - 57,867,710 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11757,781,069 - 57,856,545 (-)NCBI
Celera1745,497,321 - 45,768,089 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gli3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620272
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.