GLI3 (GLI family zinc finger 3) - Rat Genome Database
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Gene: GLI3 (GLI family zinc finger 3) Canis lupus familiaris
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Symbol: GLI3
Name: GLI family zinc finger 3
RGD ID: 12174088
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anatomical structure development (ortholog); anatomical structure formation involved in morphogenesis (ortholog); anterior semicircular canal development (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH Abnormal Reflexes (ortholog); anodontia (ortholog); Anorectal Malformations (ortholog); FOUND IN axoneme (ortholog); cilium (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome); LOW QUALITY PROTEIN: transcriptional activator GLI3; transcriptional activator GLI3; zinc finger protein GLI3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl187,801,394 - 8,068,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1187,800,817 - 8,071,531 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure development  (ISO)
anatomical structure formation involved in morphogenesis  (ISO)
anterior semicircular canal development  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
artery development  (IEA,ISO)
axon guidance  (IEA,ISO)
brain development  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
camera-type eye development  (ISO)
camera-type eye morphogenesis  (IEA,ISO)
cell differentiation involved in kidney development  (IEA,ISO)
central nervous system development  (ISO)
cerebral cortex radial glia guided migration  (ISO)
developmental growth  (IEA,ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic digestive tract development  (ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (IEA,ISO)
embryonic organ development  (IEA)
embryonic skeletal system morphogenesis  (ISO)
forebrain development  (ISO)
forebrain dorsal/ventral pattern formation  (IEA,ISO)
forebrain radial glial cell differentiation  (IEA,ISO)
frontal suture morphogenesis  (IEA,ISO)
heart development  (IEA,ISO)
hindgut morphogenesis  (IEA,ISO)
hippocampus development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inner ear development  (ISO)
kidney development  (ISO)
lambdoid suture morphogenesis  (IEA,ISO)
larynx morphogenesis  (IEA,ISO)
lateral ganglionic eminence cell proliferation  (IEA,ISO)
lateral semicircular canal development  (IEA,ISO)
layer formation in cerebral cortex  (IEA,ISO)
limb development  (ISO)
limb morphogenesis  (ISO)
liver regeneration  (ISO)
lung development  (IEA,ISO)
mammary gland development  (ISO)
mammary gland specification  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
metanephros development  (IEA,ISO)
negative regulation of alpha-beta T cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
negative thymic T cell selection  (IEA,ISO)
neural tube development  (ISO)
neuron fate commitment  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
oligodendrocyte differentiation  (IEA,ISO)
optic nerve morphogenesis  (IEA,ISO)
pallium development  (ISO)
pattern specification process  (ISO)
positive regulation of alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of chondrocyte differentiation  (IEA,ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland development  (ISO)
protein processing  (IEA,ISO)
proximal/distal pattern formation  (IEA,ISO)
regulation of apoptotic process  (ISO)
regulation of bone development  (IEA,ISO)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of transcription, DNA-templated  (ISO)
response to estrogen  (ISO)
roof of mouth development  (IEA,ISO)
sagittal suture morphogenesis  (IEA,ISO)
smoothened signaling pathway  (IBA,IEA,ISO)
smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (IEA,ISO)
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  (IEA,ISO)
smoothened signaling pathway involved in ventral spinal cord interneuron specification  (IEA,ISO)
spinal cord dorsal/ventral patterning  (ISO)
spinal cord motor neuron differentiation  (ISO)
subpallium development  (ISO)
T cell differentiation in thymus  (ISO)
telencephalon development  (ISO)
thymocyte apoptotic process  (IEA,ISO)
tongue development  (IEA,ISO)
tube development  (ISO)
vocalization behavior  (IEA,ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GLI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl187,801,394 - 8,068,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1187,800,817 - 8,071,531 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
GLI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl741,960,949 - 42,264,100 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl741,960,949 - 42,237,870 (-)EnsemblGRCh38hg38GRCh38
GRCh38741,960,949 - 42,237,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37742,000,547 - 42,276,808 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37742,000,547 - 42,277,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36741,967,072 - 42,243,137 (-)NCBINCBI36hg18NCBI36
Build 34741,776,919 - 42,036,135NCBI
Celera741,991,319 - 42,267,350 (-)NCBI
Cytogenetic Map7p14.1NCBI
HuRef741,885,427 - 42,162,362 (-)NCBIHuRef
CHM1_1742,003,855 - 42,280,223 (-)NCBICHM1_1
CRA_TCAGchr7v2742,040,400 - 42,316,460 (-)NCBI
Gli3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391315,638,308 - 15,904,611 (+)NCBIGRCm39mm39
GRCm381315,463,723 - 15,730,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1315,463,235 - 15,730,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371315,555,556 - 15,821,859 (+)NCBIGRCm37mm9NCBIm37
MGSCv361315,254,867 - 15,517,860 (+)NCBImm8
Celera1315,745,941 - 16,017,370 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.43NCBI
Gli3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21749,438,567 - 49,709,712 (-)NCBI
Rnor_6.0 Ensembl1752,294,942 - 52,569,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01752,294,942 - 52,569,036 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01750,360,049 - 50,629,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,594,102 - 57,867,710 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11757,781,069 - 57,856,545 (-)NCBI
Celera1745,497,321 - 45,768,089 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Gli3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554601,528,412 - 1,805,918 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554601,528,457 - 1,805,584 (+)NCBIChiLan1.0ChiLan1.0
GLI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1742,056,566 - 42,322,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl742,056,565 - 42,322,865 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0742,004,965 - 42,280,772 (+)NCBIMhudiblu_PPA_v0panPan3
Gli3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647817,129,922 - 17,403,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1852,404,071 - 52,697,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11852,403,463 - 52,697,906 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21857,616,734 - 57,801,327 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLI3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12116,386,700 - 16,665,648 (+)NCBI
ChlSab1.1 Ensembl2116,549,789 - 16,662,238 (+)Ensembl
Gli3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474018,961,395 - 19,238,760 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3
Low 5 5 16 6 3 12 8 10 6
Below cutoff 6 6 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000005687   ⟹   ENSCAFP00000005264
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl187,867,912 - 8,068,132 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049220   ⟹   ENSCAFP00000039478
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl187,801,394 - 8,068,132 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083413   ⟹   ENSCAFP00000053471
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl187,879,793 - 8,068,132 (+)Ensembl
RefSeq Acc Id: XM_014120825   ⟹   XP_013976300
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1187,887,057 - 8,071,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022405177   ⟹   XP_022260885
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1187,867,803 - 8,071,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022405178   ⟹   XP_022260886
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1187,867,803 - 8,071,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_540363   ⟹   XP_540363
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1187,800,817 - 8,071,531 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_540363   ⟸   XM_540363
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013976300   ⟸   XM_014120825
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022260885   ⟸   XM_022405177
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022260886   ⟸   XM_022405178
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000005264   ⟸   ENSCAFT00000005687
RefSeq Acc Id: ENSCAFP00000039478   ⟸   ENSCAFT00000049220
RefSeq Acc Id: ENSCAFP00000053471   ⟸   ENSCAFT00000083413
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003535 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000005264 UniProtKB/TrEMBL
  ENSCAFP00000039478 UniProtKB/TrEMBL
  ENSCAFP00000053471 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005687 UniProtKB/TrEMBL
  ENSCAFT00000049220 UniProtKB/TrEMBL
  ENSCAFT00000083413 UniProtKB/TrEMBL
InterPro GLI-like UniProtKB/TrEMBL
  GLI3 UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene GLI3 ENTREZGENE
PANTHER PTHR45718 UniProtKB/TrEMBL
  PTHR45718:SF5 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A5F4CGT1_CANLF UniProtKB/TrEMBL
  F1PE83_CANLF UniProtKB/TrEMBL
  J9P1Q3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41258 ENTREZGENE