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Gene: GLI3 (GLI family zinc finger 3) Homo sapiens
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Symbol: GLI3
Name: GLI family zinc finger 3
Description: Exhibits several functions, including beta-catenin binding activity; enzyme binding activity; and mediator complex binding activity. Involved in limb morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Localizes to the cilium; cytosol; and nucleus. Implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACLS; DNA-binding protein; GCPS; GLI-Kruppel family member GLI3; GLI3 form of 190 kDa; GLI3 full length protein; GLI3-190; GLI3FL; glioma-associated oncogene family zinc finger 3; oncogene GLI3; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV; transcriptional activator GLI3; zinc finger protein GLI3
Orthologs:
Mus musculus (house mouse) : Gli3 (GLI-Kruppel family member GLI3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gli3 (GLI family zinc finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli3 (GLI family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI3 (GLI family zinc finger 3)
Canis lupus familiaris (dog) : GLI3 (GLI family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli3 (GLI family zinc finger 3)
Sus scrofa (pig) : GLI3 (GLI family zinc finger 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl741,960,949 - 42,237,870 (-)Ensembl
GRCh38741,960,949 - 42,237,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37742,000,547 - 42,277,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36741,967,072 - 42,243,137 (-)NCBINCBI36hg18NCBI36
Build 34741,776,919 - 42,036,135NCBI
Celera741,991,319 - 42,267,350 (-)NCBI
Cytogenetic Map7p14.1NCBI
HuRef741,885,427 - 42,162,362 (-)NCBIHuRef
CHM1_1742,003,855 - 42,280,223 (-)NCBICHM1_1
CRA_TCAGchr7v2742,040,400 - 42,316,460 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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