Uqcrfs1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) - Rat Genome Database

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Gene: Uqcrfs1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) Rattus norvegicus
Analyze
Symbol: Uqcrfs1
Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
RGD ID: 628838
Description: Predicted to enable oxidoreductase activity. Involved in response to hormone and response to xenobiotic stimulus. Located in mitochondrial membrane. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: complex III subunit 5; cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial; liver regeneration-related protein LRRGT00195; LRRGT00195; MGC105530; rieske iron-sulfur protein; Rieske protein UQCRFS1; RISP; ubiquinol-cytochrome c reductase iron-sulfur subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,173,787 - 34,190,952 (+)NCBIGRCr8
mRatBN7.21733,977,908 - 33,982,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,977,921 - 33,982,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1733,816,701 - 33,820,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,420,584 - 35,424,845 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,812,512 - 33,816,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,677,984 - 35,682,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,677,984 - 35,682,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01736,991,588 - 36,995,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,429,806 - 40,434,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,432,755 - 40,436,859 (+)NCBI
Celera1733,517,087 - 33,521,364 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-naphthylamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
antimycin A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium dichloride  (EXP)
choline  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (EXP)
daunorubicin  (EXP)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
hesperetin  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
melittin  (ISO)
metronidazole  (EXP)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nicotine  (ISO)
oxybenzone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (EXP)
pirinixic acid  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
tolcapone  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
vancomycin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. He L and Lemasters JJ, Biochem Biophys Res Commun. 2005 Sep 2;334(3):829-37.
3. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. Jeyaseelan R, etal., J Biol Chem. 1997 Feb 28;272(9):5828-32.
4. Thyroid hormone regulation of nuclear-encoded mitochondrial inner membrane polypeptides of the liver. Joste V, etal., Eur J Biochem. 1989 Sep 1;184(1):255-60.
5. Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Junker H, etal., Epilepsia. 2005 Mar;46(3):339-43.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Alteration of renal respiratory Complex-III during experimental type-1 diabetes. Munusamy S, etal., BMC Endocr Disord. 2009 Jan 23;9:2.
8. Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex. Nishikimi M, etal., Biochem Biophys Res Commun 1989 Feb 28;159(1):19-25.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase. Sun G, etal., J Mass Spectrom 2003 May;38(5):531-9.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:16120479   PMID:17634366   PMID:18614015   PMID:20833797   PMID:21700703   PMID:23168492   PMID:28844695   PMID:29476059   PMID:30053369  
PMID:31505169   PMID:35352799  


Genomics

Comparative Map Data
Uqcrfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,173,787 - 34,190,952 (+)NCBIGRCr8
mRatBN7.21733,977,908 - 33,982,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,977,921 - 33,982,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1733,816,701 - 33,820,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,420,584 - 35,424,845 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,812,512 - 33,816,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,677,984 - 35,682,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,677,984 - 35,682,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01736,991,588 - 36,995,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,429,806 - 40,434,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,432,755 - 40,436,859 (+)NCBI
Celera1733,517,087 - 33,521,364 (+)NCBICelera
Cytogenetic Map17p12NCBI
UQCRFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381929,205,320 - 29,213,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1929,205,320 - 29,213,151 (-)EnsemblGRCh38hg38GRCh38
GRCh371929,696,227 - 29,704,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361934,390,007 - 34,395,954 (-)NCBINCBI36Build 36hg18NCBI36
Build 341934,390,006 - 34,395,954NCBI
Celera1926,400,450 - 26,406,405 (-)NCBICelera
Cytogenetic Map19q12NCBI
HuRef1926,215,131 - 26,221,101 (-)NCBIHuRef
CHM1_11929,699,125 - 29,705,094 (-)NCBICHM1_1
T2T-CHM13v2.01931,736,436 - 31,744,253 (-)NCBIT2T-CHM13v2.0
Uqcrfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,724,295 - 30,729,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,724,291 - 30,729,345 (-)EnsemblGRCm39 Ensembl
GRCm381330,540,312 - 30,545,316 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,540,308 - 30,545,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv371330,632,181 - 30,637,185 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,547,777 - 30,552,785 (-)NCBIMGSCv36mm8
Celera1330,754,531 - 30,759,562 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.23NCBI
LOC102014998
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554688,331,153 - 8,338,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554688,331,153 - 8,338,628 (+)NCBIChiLan1.0ChiLan1.0
LOC100974890
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22035,192,052 - 35,197,971 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11937,188,573 - 37,194,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01926,139,335 - 26,145,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11934,905,765 - 34,911,712 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1934,905,765 - 34,911,712 (-)Ensemblpanpan1.1panPan2
UQCRFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,035,193 - 122,038,032 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,035,197 - 122,037,759 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,336,791 - 121,339,788 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,668,156 - 122,671,153 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,668,169 - 122,672,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,243,598 - 122,246,656 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,850,901 - 121,854,019 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,914,720 - 122,918,053 (+)NCBIUU_Cfam_GSD_1.0
LOC101959727
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093495,595,723 - 5,600,927 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365706,044,969 - 6,051,046 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522678
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl639,364,890 - 39,373,872 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1639,366,761 - 39,373,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2634,525,752 - 34,530,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103234417
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1624,293,640 - 24,298,983 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl624,293,920 - 24,299,043 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660731,814,696 - 1,820,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101708594
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247944,430,723 - 4,435,457 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247944,428,339 - 4,435,363 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uqcrfs1
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:45
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000024609
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat

Markers in Region
RH143354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,977,967 - 33,978,070 (+)MAPPERmRatBN7.2
Rnor_6.01735,677,992 - 35,678,094NCBIRnor6.0
Rnor_5.01736,991,596 - 36,991,698UniSTSRnor5.0
RGSC_v3.41740,429,814 - 40,429,916UniSTSRGSC3.4
Celera1733,517,095 - 33,517,197UniSTS
RH 3.4 Map17375.9UniSTS
Cytogenetic Map17p12UniSTS
RH127960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,982,051 - 33,982,271 (+)MAPPERmRatBN7.2
Rnor_6.01735,682,077 - 35,682,296NCBIRnor6.0
Rnor_5.01736,995,681 - 36,995,900UniSTSRnor5.0
RGSC_v3.41740,433,898 - 40,434,117UniSTSRGSC3.4
Celera1733,521,179 - 33,521,398UniSTS
RH 3.4 Map17375.9UniSTS
Cytogenetic Map17p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 41 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY539946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000024609   ⟹   ENSRNOP00000024609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1733,977,921 - 33,982,479 (+)Ensembl
Rnor_6.0 Ensembl1735,677,984 - 35,682,259 (+)Ensembl
RefSeq Acc Id: NM_001008888   ⟹   NP_001008888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,186,602 - 34,190,879 (+)NCBI
mRatBN7.21733,977,960 - 33,982,237 (+)NCBI
Rnor_6.01735,677,984 - 35,682,262 (+)NCBI
Rnor_5.01736,991,588 - 36,995,866 (+)NCBI
RGSC_v3.41740,429,806 - 40,434,083 (+)RGD
Celera1733,517,087 - 33,521,364 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276184   ⟹   XP_063132254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,173,787 - 34,190,952 (+)NCBI
RefSeq Acc Id: NP_001008888   ⟸   NM_001008888
- UniProtKB: Q6QI13 (UniProtKB/Swiss-Prot),   P20788 (UniProtKB/Swiss-Prot),   A6J7M2 (UniProtKB/TrEMBL),   A6J7M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024609   ⟸   ENSRNOT00000024609
RefSeq Acc Id: XP_063132254   ⟸   XM_063276184
- Peptide Label: isoform X1
- UniProtKB: Q6QI13 (UniProtKB/Swiss-Prot),   P20788 (UniProtKB/Swiss-Prot),   A6J7M3 (UniProtKB/TrEMBL),   A6J7M2 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20788-F1-model_v2 AlphaFold P20788 1-274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700427
Promoter ID:EPDNEW_R10951
Type:initiation region
Name:Uqcrfs1_1
Description:ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01735,677,970 - 35,678,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628838 AgrOrtholog
BioCyc Gene G2FUF-9531 BioCyc
Ensembl Genes ENSRNOG00000018281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024609 ENTREZGENE
  ENSRNOT00000024609.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.270 UniProtKB/Swiss-Prot
  2.102.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquinol cytochrome reductase, transmembrane domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302533 IMAGE-MGC_LOAD
InterPro bc1_Rieske_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globular_prot_asu/bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_2Fe-2S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_2Fe-2S_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_Fe-S_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_Fe-S_prot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiqinol_cyt_c_Rdtase_N UniProtKB/Swiss-Prot
  Ubiquinol_cyt_c_Rdtase_Fe-S-su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UQCRFS1_N UniProtKB/TrEMBL
KEGG Report rno:291103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105530 IMAGE-MGC_LOAD
NCBI Gene Uqcrfs1 ENTREZGENE
PANTHER CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL UniProtKB/TrEMBL
  CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10134 UniProtKB/Swiss-Prot
Pfam Rieske UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiq-Cytc-red_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UCR_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uqcrfs1 PhenoGen
PRINTS RIESKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RIESKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018281 RatGTEx
Superfamily-SCOP ISP domain UniProtKB/TrEMBL
  ISP transmembrane anchor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Non-globular alpha+beta subunits of globular proteins UniProtKB/TrEMBL
  SSF50022 UniProtKB/Swiss-Prot
  SSF56568 UniProtKB/Swiss-Prot
UniProt A6J7M1_RAT UniProtKB/TrEMBL
  A6J7M2 ENTREZGENE, UniProtKB/TrEMBL
  A6J7M3 ENTREZGENE, UniProtKB/TrEMBL
  P20788 ENTREZGENE
  Q6QI13 ENTREZGENE
  UCRI_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6QI13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Uqcrfs1  ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Uqcrfs1  ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in the liver 729966
gene_protein predicted protein consists of 196 aa residues and masses 21.4 kDa 729966