Gmds (GDP-mannose 4, 6-dehydratase)

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Gene: Gmds (GDP-mannose 4, 6-dehydratase) Rattus norvegicus

Analyze

Symbol:

Gmds

Name:

GDP-mannose 4, 6-dehydratase

RGD ID:

1311008

Description:

Predicted to enable GDP-mannose 4,6-dehydratase activity; NADP+ binding activity; and identical protein binding activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and Notch signaling pathway. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GDP-mannose 4,6 dehydratase; GDP-mannose 4,6-dehydratase; LOC291095; MGC125154

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GMDS (GDP-mannose 4,6-dehydratase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gmds (GDP-mannose 4, 6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gmds (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GMDS (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GMDS (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gmds (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GMDS (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GMDS (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gmds (GDP-mannose 4,6-dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GMDS (GDP-mannose 4,6-dehydratase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gmds (GDP-mannose 4, 6-dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gmds (GDP-mannose 4,6-dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bre-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gmd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gmd-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	32,095,315 - 32,621,975 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	32,095,386 - 32,621,961 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	31,943,309 - 32,469,749 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	33,547,114 - 34,073,564 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	31,939,117 - 32,465,571 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	33,408,722 - 33,938,086 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	33,408,722 - 33,938,085 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	35,298,853 - 35,824,292 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	38,461,733 - 39,016,771 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	31,657,264 - 32,181,220 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aniridia (ISO)

genetic disease (ISO)

open-angle glaucoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzalutamide (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

GDP (ISO)

genistein (ISO)

guanosine 5'-[beta,gamma-imido]triphosphate (ISO)

guanosine 5'-monophosphate (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

temozolomide (ISO)

testosterone (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (ISO)

Triptolide (EXP)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' GDP-L-fucose biosynthetic process (IBA,IEA,ISO,ISS)

GDP-mannose metabolic process (ISO,ISS)

Notch signaling pathway (ISS)

Cellular Component

cellular_component (ND)

Molecular Function

GDP-mannose 4,6-dehydratase activity (IBA,ISO,ISS)

identical protein binding (ISO)

NADP+ binding (ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (IEA)

fructose and mannose metabolic pathway (IEA,ISO)

fructosuria pathway (ISO)

hereditary fructose intolerance syndrome pathway (ISO)

nucleotide sugar metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.	Gharahkhani P, etal., Nat Genet. 2014 Oct;46(10):1120-1125. doi: 10.1038/ng.3079. Epub 2014 Aug 31.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9525924	PMID:9603974	PMID:12477932	PMID:16189514	PMID:19199708	PMID:25416956	PMID:31515488

Genomics

Comparative Map Data

Gmds
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	32,095,315 - 32,621,975 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	32,095,386 - 32,621,961 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	31,943,309 - 32,469,749 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	33,547,114 - 34,073,564 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	31,939,117 - 32,465,571 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	33,408,722 - 33,938,086 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	33,408,722 - 33,938,085 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	35,298,853 - 35,824,292 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	38,461,733 - 39,016,771 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	31,657,264 - 32,181,220 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

GMDS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	1,623,806 - 2,245,605 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	1,623,806 - 2,245,605 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	1,624,041 - 2,245,839 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	1,569,040 - 2,190,845 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	1,569,040 - 2,190,845	NCBI
Celera	6	2,852,269 - 3,473,926 (-)	NCBI		Celera
Cytogenetic Map	6	p25.3	NCBI
HuRef	6	1,493,473 - 2,117,107 (-)	NCBI		HuRef
CHM1_1	6	1,625,952 - 2,247,981 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	1,486,810 - 2,109,239 (-)	NCBI		T2T-CHM13v2.0

Gmds
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	32,003,566 - 32,522,744 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	32,003,562 - 32,522,723 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	31,819,583 - 32,338,762 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	31,819,579 - 32,338,740 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	31,911,455 - 32,430,413 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	31,827,051 - 32,346,009 (-)	NCBI		MGSCv36	mm8
Celera	13	32,029,445 - 32,552,254 (-)	NCBI		Celera
Cytogenetic Map	13	A3.2	NCBI

Gmds
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	11,145,837 - 11,563,352 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	11,133,513 - 11,562,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

GMDS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	1,559,444 - 2,178,324 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	1,556,227 - 2,178,330 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	1,443,129 - 2,071,856 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GMDS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	2,108,459 - 2,519,902 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	2,151,528 - 2,519,513 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	2,079,228 - 2,654,331 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	2,025,524 - 2,554,965 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	35	2,000,500 - 2,575,207 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	2,021,716 - 2,596,616 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	3,357,422 - 3,932,361 (-)	NCBI		UU_Cfam_GSD_1.0

Gmds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	23,253,265 - 23,867,993 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936633	2,752,443 - 3,367,443 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936633	2,752,677 - 3,367,408 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMDS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	752,592 - 1,285,550 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	849,088 - 1,285,563 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	1,047,471 - 1,386,586 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GMDS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	69,899,089 - 70,523,126 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	1,566,497 - 2,196,283 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmds
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	22,504,499 - 23,051,938 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	22,504,483 - 23,051,215 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gmds
1480 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	280
Count of miRNA genes:	172
Interacting mature miRNAs:	195
Transcripts:	ENSRNOT00000023691
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27027949	36146731	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	31990784	50909196	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat

Markers in Region

D17Rat155

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,131,636 - 32,131,780 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	33,444,804 - 33,444,947	NCBI	Rnor6.0
Rnor_5.0	17	35,334,935 - 35,335,078	UniSTS	Rnor5.0
RGSC_v3.4	17	38,497,648 - 38,497,792	RGD	RGSC3.4
RGSC_v3.4	17	38,497,649 - 38,497,792	UniSTS	RGSC3.4
RGSC_v3.1	17	38,500,489 - 38,500,633	RGD
Celera	17	31,693,380 - 31,693,523	UniSTS
FHH x ACI Map	17	30.0699	RGD
FHH x ACI Map	17	30.0699	UniSTS
Cytogenetic Map	17	p12	UniSTS

D17Rat178

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,608,930 - 32,609,135 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	33,925,056 - 33,925,258	NCBI	Rnor6.0
Rnor_5.0	17	35,811,262 - 35,811,464	UniSTS	Rnor5.0
RGSC_v3.4	17	39,003,740 - 39,003,943	RGD	RGSC3.4
RGSC_v3.4	17	39,003,741 - 39,003,943	UniSTS	RGSC3.4
RGSC_v3.1	17	39,006,581 - 39,006,784	RGD
Celera	17	32,168,190 - 32,168,392	UniSTS
FHH x ACI Map	17	30.0699	RGD
FHH x ACI Map	17	30.0699	UniSTS
Cytogenetic Map	17	p12	UniSTS

BF387292

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,480,827 - 32,480,977 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	33,797,923 - 33,798,072	NCBI	Rnor6.0
Rnor_5.0	17	35,684,038 - 35,684,187	UniSTS	Rnor5.0
RGSC_v3.4	17	38,872,423 - 38,872,572	UniSTS	RGSC3.4
Celera	17	32,040,820 - 32,040,969	UniSTS
RH 3.4 Map	17	376.51	UniSTS
Cytogenetic Map	17	p12	UniSTS

D13Cwr18

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,532,340 - 32,532,608 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	33,849,161 - 33,849,428	NCBI	Rnor6.0
Rnor_5.0	17	35,735,081 - 35,735,348	UniSTS	Rnor5.0
RGSC_v3.4	17	38,924,858 - 38,925,125	UniSTS	RGSC3.4
Celera	17	32,092,330 - 32,092,597	UniSTS
Cytogenetic Map	17	p12	UniSTS

RH143469

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,551,417 - 32,551,621 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	33,867,392 - 33,867,595	NCBI	Rnor6.0
Rnor_5.0	17	35,753,598 - 35,753,801	UniSTS	Rnor5.0
RGSC_v3.4	17	38,946,230 - 38,946,433	UniSTS	RGSC3.4
Celera	17	32,110,826 - 32,111,029	UniSTS
RH 3.4 Map	17	374.3	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	10	8	12	8			71	27	30	9
Low		23	44	30	7	30	8	11	3	8	11	2	8
Below cutoff			3	3		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC104708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000023691 ⟹ ENSRNOP00000023691

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	32,095,396 - 32,621,961 (+)	Ensembl
Rnor_6.0 Ensembl	17	33,408,722 - 33,938,085 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104164 ⟹ ENSRNOP00000078985

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	32,095,386 - 32,527,914 (+)	Ensembl

RefSeq Acc Id:

NM_001039606 ⟹ NP_001034695

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	32,095,517 - 32,621,964 (+)	NCBI
Rnor_6.0	17	33,408,722 - 33,938,086 (+)	NCBI
Rnor_5.0	17	35,298,853 - 35,824,292 (+)	NCBI
RGSC_v3.4	17	38,461,733 - 39,016,771 (+)	RGD
Celera	17	31,657,264 - 32,181,220 (+)	RGD

Sequence:

show sequence

CGCTCACCCGCCTGAAGCGACATGGCCCACGCTCCCGCTAGCTGCCGGAGATACCCGGGCTCCG
GGGATGGCGAGATGGGCAAGCTCAGGAAGGTAGCTCTCATCACCGGCATCACTGGCCAGGATGG
TTCATACTTGGCAGAATTCCTGCTGGAGAAAGGATACGAGGTCCATGGAATAGTACGGCGATCT
AGTTCATTTAATACAGGTCGAATTGAACATTTATATAAGAATCCTCAGGCTCATATTGAAGGAA
ACATGAAGTTGCACTATGGCGACCTGACTGACAGCACCTGCCTGGTGAAAATCATCAATGAAGT
GAAGCCTACAGAGATCTACAATCTTGGCGCTCAGAGCCATGTCAAGATCTCCTTTGACTTAGCT
GAATACACCGCAGACGTTGATGGAGTTGGCACCTTGCGGCTTCTGGATGCAATTAAAACTTGCG
GCCTTATAAATTCTGTGAAGTTCTACCAGGCCTCGACAAGTGAACTTTATGGAAAAGTTCAGGA
AATACCCCAGAAAGAGACCACACCTTTCTATCCGAGGTCACCCTATGGAGCCGCCAAGCTCTAT
GCCTATTGGATTGTGGTGAATTTCCGTGAAGCTTATAATCTCTTTGCAGTGAATGGCATTCTCT
TCAATCACGAGAGCCCCAGAAGAGGAGCTAATTTTGTTACTCGAAAAATTAGCCGGTCAGTAGC
TAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGACTGG
GGCCATGCCAAGGACTATGTAGAGGCTATGTGGCTGATGTTGCAAAATGATGAGCCGGAGGACT
TTGTCATAGCTACTGGGGAAGTTCACAGTGTCCGTGAATTTGTTGAAAAATCATTCATGCACAT
TGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTAGGCAGATGTAAGGAGACCGGC
AAAATTCACGTGACTGTGGATCTGAAATACTACCGACCGACTGAAGTGGACTTTCTACAGGGAG
ACTGCTCCAAGGCTCAGCAGAAACTGAACTGGAAACCCCGCGTTGCCTTCGATGAGCTGGTGAG
AGAGATGGTGCAGGCCGACGTGGAGCTCATGAGGACCAACCCCAACGCTTGAGCCCCTCTGCAG
AAACTAGAGGCATGGCAACAGTGCAGAGCCAGTGAACCGGAGTTCAGTCACTCCTGCCAATCAT
GGACCCTCGACCTCCTGTGTTGTCCCTGCATCTAGAGCTGGGCCACAGAGGTTTGTAGACCCCA
AGACAGGACACGCCAGACCTAAGGCCGCATTGCTTTTGTCAAAGCCTCCTCTGAATGGTTTTGG
GAAATCAAGAAGTTTTAATCACATATTCATTTTACTTGAAATTATGTCACTAGACAACTTATAT
TTTGGAGTCTTGAGATTGTTTTTCTCTTTTCTTATTAAATAATCTTTCTATAAACTAAAAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039095494 ⟹ XP_038951422

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	32,095,321 - 32,621,975 (+)	NCBI

RefSeq Acc Id:

XM_039095495 ⟹ XP_038951423

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	32,148,801 - 32,621,975 (+)	NCBI

RefSeq Acc Id:

XM_039095496 ⟹ XP_038951424

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	32,289,740 - 32,621,975 (+)	NCBI

RefSeq Acc Id:

XM_039095497 ⟹ XP_038951425

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	32,095,315 - 32,366,819 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034695	(Get FASTA)	NCBI Sequence Viewer
	XP_038951422	(Get FASTA)	NCBI Sequence Viewer
	XP_038951423	(Get FASTA)	NCBI Sequence Viewer
	XP_038951424	(Get FASTA)	NCBI Sequence Viewer
	XP_038951425	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI04709	(Get FASTA)	NCBI Sequence Viewer
	EDL98349	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001034695 ⟸ NM_001039606

- UniProtKB:

Q3MHS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHAPASCRRYPGSGDGEMGKLRKVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGR
IEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVD
GVGTLRLLDAIKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVN
FREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYV
EAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFMHIGKTIVWEGKNENEVGRCKETGKIHVTVD
LKYYRPTEVDFLQGDCSKAQQKLNWKPRVAFDELVREMVQADVELMRTNPNA

hide sequence

RefSeq Acc Id:

ENSRNOP00000023691 ⟸ ENSRNOT00000023691

RefSeq Acc Id:	XP_038951425 ⟸ XM_039095497
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038951422 ⟸ XM_039095494
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038951423 ⟸ XM_039095495
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038951424 ⟸ XM_039095496
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000078985 ⟸ ENSRNOT00000104164

Protein Domains

NAD(P)-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3MHS7-F1-model_v2	AlphaFold	Q3MHS7	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311008	AgrOrtholog
BioCyc Gene	G2FUF-9561	BioCyc
BioCyc Pathway	PWY-66 [GDP-L-fucose biosynthesis I (from GDP-D-mannose)]	BioCyc
Ensembl Genes	ENSRNOG00000017605	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000023691	ENTREZGENE
	ENSRNOP00000023691.4	UniProtKB/TrEMBL
	ENSRNOP00000078985.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023691	ENTREZGENE
	ENSRNOT00000023691.6	UniProtKB/TrEMBL
	ENSRNOT00000104164.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	UDP-galactose 4-epimerase, domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7317156	IMAGE-MGC_LOAD
InterPro	GDP_Man_deHydtase	UniProtKB/TrEMBL
	NAD(P)-bd_dom	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:291095	UniProtKB/TrEMBL
MGC_CLONE	MGC:125154	IMAGE-MGC_LOAD
NCBI Gene	291095	ENTREZGENE
PANTHER	GDP-MANNOSE 4,6 DEHYDRATASE	UniProtKB/TrEMBL
	PTHR43715	UniProtKB/TrEMBL
Pfam	GDP_Man_Dehyd	UniProtKB/TrEMBL
PhenoGen	Gmds	PhenoGen
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
TIGRFAMs	gmd	UniProtKB/TrEMBL
UniProt	A0A8I5ZPV8_RAT	UniProtKB/TrEMBL
	Q3MHS7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-07	Gmds	GDP-mannose 4, 6-dehydratase	Gmds_predicted	GDP-mannose 4, 6-dehydratase (predicted)	Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Gmds_predicted	GDP-mannose 4, 6-dehydratase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)