Hist1h4m (histone cluster 1, H4m) - Rat Genome Database

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Gene: Hist1h4m (histone cluster 1, H4m) Rattus norvegicus
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Symbol: Hist1h4m
Name: histone cluster 1, H4m
RGD ID: 1306905
Description: Predicted to enable protein domain specific binding activity. Predicted to be involved in DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; and negative regulation of megakaryocyte differentiation. Predicted to be located in nuclear chromosome. Predicted to be part of nucleosome; PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH ammonium chloride; decabromodiphenyl ether; 1-chloro-2,4-dinitrobenzene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H4c2; H4f16; Hist1h4b; Hist4h4; histone 1, H4m; histone H4; LOC291152
RGD Orthologs
Human
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21742,698,054 - 42,698,365 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1744,815,684 - 44,815,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01758,668,364 - 58,668,482 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41750,332,406 - 50,332,717 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11750,335,246 - 50,335,558 (+)NCBI
Celera1753,762,977 - 53,763,288 (-)NCBICelera
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1582415   PMID:1706721   PMID:2920170   PMID:3691674   PMID:5171427   PMID:7932740   PMID:10318873   PMID:14585971   PMID:14718166   PMID:15489334   PMID:16042990   PMID:18474616  
PMID:20498094   PMID:21636898   PMID:22368283   PMID:23469244   PMID:24699735   PMID:25615412   PMID:28259758   PMID:31904090  


Genomics

Comparative Map Data
Hist1h4m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21742,698,054 - 42,698,365 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1744,815,684 - 44,815,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01758,668,364 - 58,668,482 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41750,332,406 - 50,332,717 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11750,335,246 - 50,335,558 (+)NCBI
Celera1753,762,977 - 53,763,288 (-)NCBICelera
Cytogenetic Map17q11NCBI
H4C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl626,021,649 - 26,022,050 (+)EnsemblGRCh38hg38GRCh38
GRCh38626,021,649 - 26,022,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37626,021,877 - 26,022,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,129,886 - 26,130,257 (+)NCBINCBI36hg18NCBI36
Build 34626,129,885 - 26,130,257NCBI
Celera627,249,131 - 27,249,502 (+)NCBI
Cytogenetic Map6p22.2NCBI
HuRef625,964,973 - 25,965,344 (+)NCBIHuRef
CHM1_1626,024,180 - 26,024,551 (+)NCBICHM1_1
LOC101974797
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049461,739,169 - 1,741,151 (-)NCBI
SpeTri2.0NW_0049366711,881,645 - 1,882,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC101707460
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624756881,773 - 882,657 (-)NCBI

Position Markers
UniSTS:487787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21742,696,177 - 42,696,558 (+)MAPPERmRatBN7.2
Rnor_6.01744,737,950 - 44,738,330NCBIRnor6.0
Rnor_5.01758,730,907 - 58,731,287UniSTSRnor5.0
RGSC_v3.41750,330,186 - 50,330,566UniSTSRGSC3.4
Celera1753,764,784 - 53,765,164UniSTS
Cytogenetic Map17q11UniSTS
UniSTS:488585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21742,696,177 - 42,696,558 (+)MAPPERmRatBN7.2
Rnor_6.01744,737,950 - 44,738,330NCBIRnor6.0
Rnor_5.01758,730,907 - 58,731,287UniSTSRnor5.0
RGSC_v3.41750,330,186 - 50,330,566UniSTSRGSC3.4
Celera1753,764,784 - 53,765,164UniSTS
Cytogenetic Map17q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000071518
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_001271221   ⟹   NP_001258150
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21742,698,054 - 42,698,365 (+)NCBI
Rnor_5.01758,668,364 - 58,668,482 (-)NCBI
Celera1753,762,977 - 53,763,288 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P62804 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258150   ⟸   NM_001271221
- UniProtKB: P62804 (UniProtKB/Swiss-Prot)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000032224 UniProtKB/Swiss-Prot
  ENSRNOG00000045840 UniProtKB/Swiss-Prot
  ENSRNOG00000045978 UniProtKB/Swiss-Prot
  ENSRNOG00000046636 UniProtKB/Swiss-Prot
  ENSRNOG00000048215 UniProtKB/Swiss-Prot
  ENSRNOG00000048642 UniProtKB/Swiss-Prot
  ENSRNOG00000048735 UniProtKB/Swiss-Prot
  ENSRNOG00000050933 UniProtKB/Swiss-Prot
  ENSRNOG00000051891 UniProtKB/Swiss-Prot
  ENSRNOG00000054017 UniProtKB/Swiss-Prot
  ENSRNOG00000057690 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000058444 UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000039602 UniProtKB/Swiss-Prot
  ENSRNOP00000065233 UniProtKB/Swiss-Prot
  ENSRNOP00000066622 UniProtKB/Swiss-Prot
  ENSRNOP00000066653 UniProtKB/Swiss-Prot
  ENSRNOP00000066695 UniProtKB/Swiss-Prot
  ENSRNOP00000067176 UniProtKB/Swiss-Prot
  ENSRNOP00000067502 UniProtKB/Swiss-Prot
  ENSRNOP00000067813 UniProtKB/Swiss-Prot
  ENSRNOP00000069989 UniProtKB/Swiss-Prot
  ENSRNOP00000071163 UniProtKB/Swiss-Prot
  ENSRNOP00000074659 UniProtKB/Swiss-Prot
  ENSRNOP00000074796 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040210 UniProtKB/Swiss-Prot
  ENSRNOT00000071512 UniProtKB/Swiss-Prot
  ENSRNOT00000072147 UniProtKB/Swiss-Prot
  ENSRNOT00000072286 UniProtKB/Swiss-Prot
  ENSRNOT00000074109 UniProtKB/Swiss-Prot
  ENSRNOT00000074198 UniProtKB/Swiss-Prot
  ENSRNOT00000074526 UniProtKB/Swiss-Prot
  ENSRNOT00000075065 UniProtKB/Swiss-Prot
  ENSRNOT00000080490 UniProtKB/Swiss-Prot
  ENSRNOT00000085381 UniProtKB/Swiss-Prot
  ENSRNOT00000088408 UniProtKB/Swiss-Prot
  ENSRNOT00000091201 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
InterPro CENP-T/H4_C UniProtKB/Swiss-Prot
  Histone-fold UniProtKB/Swiss-Prot
  Histone_H4 UniProtKB/Swiss-Prot
  Histone_H4_CS UniProtKB/Swiss-Prot
  TAF_TATA-bd UniProtKB/Swiss-Prot
KEGG Report rno:291152 UniProtKB/Swiss-Prot
  rno:295277 UniProtKB/Swiss-Prot
  rno:364723 UniProtKB/Swiss-Prot
  rno:64627 UniProtKB/Swiss-Prot
NCBI Gene 291152 ENTREZGENE
Pfam CENP-T_C UniProtKB/Swiss-Prot
PhenoGen Hist1h4m PhenoGen
PRINTS HISTONEH4 UniProtKB/Swiss-Prot
PROSITE HISTONE_H4 UniProtKB/Swiss-Prot
SMART SM00417 UniProtKB/Swiss-Prot
  TAF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniProt H4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P02304 UniProtKB/Swiss-Prot
  P02305 UniProtKB/Swiss-Prot
  Q5BM23 UniProtKB/Swiss-Prot
  Q7M0E8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hist1h4m  histone cluster 1, H4m   Hist1h4m_predicted  histone cluster 1, H4m (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-07 Hist1h4m_predicted  histone cluster 1, H4m (predicted)    histone 1, H4m (predicted)  Name updated 1299863 APPROVED
2005-01-12 Hist1h4m_predicted  histone 1, H4m (predicted)      Symbol and Name status set to approved 70820 APPROVED