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Gene: Prl (prolactin) Rattus norvegicus
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Symbol: Prl
Name: prolactin
Description: Predicted to have hormone activity and prolactin receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Localizes to the extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (S)-amphetamine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Gha1; growth hormone a1; Prl1a1; PRLB; PRLSD1; Prol; prolactin family 1, subfamily a, member 1; RATPRLSD1; RNPROL
Orthologs:
Homo sapiens (human) : PRL (prolactin)  HGNC  Alliance
Mus musculus (house mouse) : Prl (prolactin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prl (prolactin)
Pan paniscus (bonobo/pygmy chimpanzee) : PRL (prolactin)
Canis lupus familiaris (dog) : PRL (prolactin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prl (prolactin)
Sus scrofa (pig) : PRL (prolactin)
more info ...
Is Marker For: Strains:   SS.LEW-(D17Rat65-Prl)/Ayd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01739,814,236 - 39,824,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01741,720,751 - 41,730,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,699,101 - 44,709,162 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11744,701,945 - 44,712,003 (-)NCBI
Celera1737,551,071 - 37,561,021 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3403
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.