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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:5613
Term: haloperidol
Definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Chemical ID: MESH:D006220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDHaloperidol results in increased expression of PRL protein

PMID:10661492, PMID:11071396, PMID:11997696, PMID:15638391, PMID:18521575, PMID:3019639, PMID:3158510, PMID:3883215, PMID:3906589, PMID:9128918
increases secretionEXP 6480464CTDHaloperidol results in increased secretion of PRL protein

PMID:1380082, PMID:8613910
multiple interactionsEXP 6480464CTDHaloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein], Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein], Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein], Haloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein], Haloperidol inhibits the reaction [talipexole results in decreased secretion of PRL protein], LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)- inhibits the reaction [Haloperidol results in increased expression of PRL protein], Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]

PMID:1380082, PMID:3158510, PMID:3906589, PMID:7670571, PMID:8613910
affects expressionISORGD:7361876480464CTDHaloperidol affects the expression of PRL protein

PMID:1304992, PMID:7214106
increases expressionISORGD:7361876480464CTDHaloperidol results in increased expression of PRL protein

PMID:11048906, PMID:15289996, PMID:16282852, PMID:2136057, PMID:7018927, PMID:7348089, PMID:8915564, PMID:9090331, PMID:9265916, PMID:9376336, PMID:9572212
increases secretionISORGD:7361876480464CTDHaloperidol results in increased secretion of PRL protein

PMID:9265911
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.