PRL (prolactin) - Rat Genome Database

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Gene: PRL (prolactin) Homo sapiens
Analyze
Symbol: PRL
Name: prolactin
RGD ID: 736187
HGNC Page HGNC
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in secretory granule. Predicted to be active in extracellular space. Implicated in carotid artery disease. Biomarker of hepatocellular carcinoma; hypoglycemia; obesity; and severe acute respiratory syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: decidual prolactin; GHA1; growth hormone A1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SS-Prltm1(PRL)Mcwi  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl622,287,244 - 22,302,826 (-)EnsemblGRCh38hg38GRCh38
GRCh38622,287,246 - 22,302,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37622,287,475 - 22,303,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36622,395,459 - 22,405,709 (-)NCBINCBI36hg18NCBI36
Build 34622,395,458 - 22,405,709NCBI
Celera623,520,776 - 23,536,391 (-)NCBI
Cytogenetic Map6p22.3NCBI
HuRef622,230,650 - 22,246,259 (-)NCBIHuRef
CHM1_1622,289,298 - 22,304,920 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-duloxetine hydrochloride  (EXP)
(Z)-chlorprothixene  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1-(3-chlorophenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-D  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-hydroxy-17beta-estradiol  (EXP)
2-methoxyethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-ethylphenol  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-Propylphenol  (ISO)
5-azacytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP,ISO)
actinomycin D  (ISO)
alpha-methyl-L-dopa  (EXP)
alpha-naphthoflavone  (ISO)
amiodarone  (ISO)
amisulpride  (EXP,ISO)
ammonia  (ISO)
ammonium chloride  (ISO)
amoxapine  (EXP)
apomorphine  (EXP)
aripiprazole  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (EXP,ISO)
bucladesine  (EXP)
buspirone  (EXP,ISO)
butan-1-ol  (EXP)
cabergoline  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
Cannabinol  (EXP)
carmoxirole  (ISO)
carmustine  (EXP)
cefpodoxime  (EXP)
cetrorelix  (ISO)
chlorpromazine  (EXP)
chlorprothixene  (EXP)
chromium atom  (EXP)
chromium(6+)  (ISO)
cimetidine  (EXP)
cisplatin  (EXP,ISO)
citalopram  (EXP)
clomiphene  (EXP)
clomipramine  (EXP)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyanazine  (ISO)
cyclosporin A  (ISO)
cyproheptadine  (EXP)
cyproterone acetate  (EXP,ISO)
cytarabine  (EXP)
D-penicillamine  (EXP)
daidzein  (ISO)
danazol  (EXP)
DDE  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
dexamethasone  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
domperidone  (EXP,ISO)
dopamine  (EXP,ISO)
doxapram  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epinine  (EXP)
equol  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
famotidine  (EXP)
fenfluramine  (EXP,ISO)
fluoxetine  (EXP,ISO)
fluphenazine  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
glyphosate  (ISO)
gossypol  (ISO)
haloperidol  (EXP,ISO)
Haloperidol decanoate  (EXP)
herbicide  (ISO)
herbimycin  (ISO)
hexachlorobenzene  (ISO)
idazoxan  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
kynurenine  (EXP)
L-ascorbic acid  (ISO)
L-tryptophan  (EXP)
labetalol  (EXP)
Lead oxide  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
letrozole  (ISO)
lisuride  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
losartan  (ISO)
magnesium atom  (EXP)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mesulergine  (ISO)
metformin  (EXP)
methadone  (EXP)
methamphetamine  (EXP)
Methanandamide  (ISO)
methomyl  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
metoclopramide  (EXP,ISO)
mifepristone  (EXP,ISO)
mirtazapine  (EXP)
Molindone  (EXP,ISO)
molybdenum atom  (EXP)
morphine  (ISO)
Moxestrol  (ISO)
N-acetyl-L-cysteine  (ISO)
N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nalbuphine  (EXP)
Nalmefene  (EXP)
Nalorphine  (EXP)
naloxone  (EXP,ISO)
nifedipine  (ISO)
nitric oxide  (EXP)
nitrofurazone  (ISO)
Nonylphenol  (ISO)
octreotide  (EXP,ISO)
olanzapine  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paliperidone palmitate  (EXP)
paraquat  (ISO)
PCB138  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perphenazine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pimozide  (EXP)
pindolol  (EXP,ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (ISO)
pyridoxal 5'-phosphate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinacrine  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
reserpine  (ISO)
resveratrol  (ISO)
rimonabant  (EXP,ISO)
risperidone  (EXP,ISO)
rottlerin  (EXP)
simazine  (ISO)
sodium arsenite  (EXP,ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
sulpiride  (EXP,ISO)
Talipexole dihydrochloride  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
Terguride  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioridazine  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toxaphene  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
trifluoperazine  (EXP)
triptorelin  (EXP,ISO)
urethane  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vitamin E  (ISO)
yohimbine  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zotepine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:743954   PMID:925136   PMID:1126929   PMID:1332868   PMID:1601394   PMID:1697858   PMID:1707126   PMID:2050267   PMID:2567059   PMID:3595901   PMID:6146607   PMID:6260780  
PMID:6325171   PMID:7221563   PMID:7984244   PMID:8015553   PMID:8421089   PMID:9207433   PMID:9220021   PMID:9266104   PMID:9626554   PMID:10690937   PMID:10854700   PMID:10935542  
PMID:10966654   PMID:11162551   PMID:11437600   PMID:11665977   PMID:11721691   PMID:11721692   PMID:11721693   PMID:11721694   PMID:11721695   PMID:11721696   PMID:11721698   PMID:11721699  
PMID:11721702   PMID:11721703   PMID:11923474   PMID:11997178   PMID:12036601   PMID:12154211   PMID:12445833   PMID:12459032   PMID:12477932   PMID:12485910   PMID:12524085   PMID:12552091  
PMID:12559630   PMID:12668883   PMID:12679477   PMID:12687277   PMID:12729745   PMID:12928232   PMID:14565846   PMID:14580717   PMID:14645190   PMID:14647416   PMID:14984591   PMID:15026085  
PMID:15031321   PMID:15063762   PMID:15192082   PMID:15218000   PMID:15489334   PMID:15504038   PMID:15645137   PMID:15993365   PMID:16045928   PMID:16103113   PMID:16133148   PMID:16187706  
PMID:16214922   PMID:16378242   PMID:16384849   PMID:16396693   PMID:16434456   PMID:16507890   PMID:16608881   PMID:16630538   PMID:16807649   PMID:16848233   PMID:16981141   PMID:17187171  
PMID:17260098   PMID:17289576   PMID:17351784   PMID:17468404   PMID:17507624   PMID:17548836   PMID:17550976   PMID:17564716   PMID:17587788   PMID:17590551   PMID:17607310   PMID:17785327  
PMID:17785459   PMID:17884785   PMID:17984948   PMID:18006630   PMID:18006851   PMID:18022314   PMID:18051367   PMID:18053149   PMID:18063946   PMID:18156207   PMID:18207134   PMID:18252943  
PMID:18403642   PMID:18425437   PMID:18432585   PMID:18556224   PMID:18636124   PMID:18647802   PMID:18752070   PMID:18771565   PMID:18843963   PMID:19051037   PMID:19086053   PMID:19115200  
PMID:19384991   PMID:19401036   PMID:19404952   PMID:19451414   PMID:19491263   PMID:19551610   PMID:19555049   PMID:19574343   PMID:19727442   PMID:19851340   PMID:19897676   PMID:20032052  
PMID:20053995   PMID:20080972   PMID:20124477   PMID:20163720   PMID:20307875   PMID:20352225   PMID:20399783   PMID:20424473   PMID:20427283   PMID:20547007   PMID:20587610   PMID:20647249  
PMID:20655519   PMID:20716560   PMID:20734064   PMID:20823101   PMID:20825378   PMID:20846890   PMID:20885978   PMID:20886416   PMID:20889499   PMID:20962042   PMID:21068074   PMID:21122264  
PMID:21125332   PMID:21146499   PMID:21163806   PMID:21164080   PMID:21177637   PMID:21226500   PMID:21262884   PMID:21277631   PMID:21305610   PMID:21331754   PMID:21500962   PMID:21524385  
PMID:21554911   PMID:21592821   PMID:21623375   PMID:21664429   PMID:21719533   PMID:21720444   PMID:21774041   PMID:21785216   PMID:21823053   PMID:21831600   PMID:21873635   PMID:21941183  
PMID:21971318   PMID:22081226   PMID:22094377   PMID:22193237   PMID:22205628   PMID:22293228   PMID:22325776   PMID:22363612   PMID:22412226   PMID:22420298   PMID:22495675   PMID:22577091  
PMID:22689615   PMID:22723625   PMID:22729360   PMID:22732335   PMID:22733751   PMID:22821332   PMID:23013937   PMID:23048206   PMID:23085263   PMID:23167807   PMID:23284291   PMID:23333304  
PMID:23378139   PMID:23445257   PMID:23445298   PMID:23530035   PMID:23541403   PMID:23619365   PMID:23626671   PMID:23639781   PMID:23660301   PMID:23729680   PMID:23744893   PMID:23758962  
PMID:23849393   PMID:23873024   PMID:23937200   PMID:24004716   PMID:24029242   PMID:24040800   PMID:24135841   PMID:24146212   PMID:24248464   PMID:24495670   PMID:24512221   PMID:24612525  
PMID:24718588   PMID:24816831   PMID:24861467   PMID:24984282   PMID:25049387   PMID:25218920   PMID:25226401   PMID:25243181   PMID:25345488   PMID:25359296   PMID:25410143   PMID:25724680  
PMID:25887963   PMID:25912488   PMID:26091810   PMID:26160091   PMID:26179930   PMID:26186194   PMID:26299069   PMID:26370377   PMID:26583155   PMID:26586670   PMID:26678441   PMID:26691151  
PMID:26697363   PMID:26720589   PMID:26831552   PMID:26862561   PMID:26944939   PMID:26980025   PMID:27003261   PMID:27026299   PMID:27128218   PMID:27184120   PMID:27322457   PMID:27357110  
PMID:27542844   PMID:27776952   PMID:27782069   PMID:27842054   PMID:27856537   PMID:28028951   PMID:28152004   PMID:28332508   PMID:28423697   PMID:28456148   PMID:28514442   PMID:28642278  
PMID:28700563   PMID:28927333   PMID:29158391   PMID:29412808   PMID:29452209   PMID:29792912   PMID:30097769   PMID:30120801   PMID:30911943   PMID:31104557   PMID:31319705   PMID:31389284  
PMID:31395607   PMID:32286456   PMID:32296183   PMID:32438209   PMID:32700179   PMID:32788631   PMID:32909148   PMID:33549007  


Genomics

Comparative Map Data
PRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl622,287,244 - 22,302,826 (-)EnsemblGRCh38hg38GRCh38
GRCh38622,287,246 - 22,302,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37622,287,475 - 22,303,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36622,395,459 - 22,405,709 (-)NCBINCBI36hg18NCBI36
Build 34622,395,458 - 22,405,709NCBI
Celera623,520,776 - 23,536,391 (-)NCBI
Cytogenetic Map6p22.3NCBI
HuRef622,230,650 - 22,246,259 (-)NCBIHuRef
CHM1_1622,289,298 - 22,304,920 (-)NCBICHM1_1
Prl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391327,241,553 - 27,249,187 (+)NCBIGRCm39mm39
GRCm39 Ensembl1327,241,553 - 27,249,188 (+)Ensembl
GRCm381327,057,570 - 27,065,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1327,057,570 - 27,065,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv371327,149,439 - 27,157,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv361327,065,041 - 27,072,647 (+)NCBImm8
Celera1327,286,739 - 27,294,373 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.25NCBI
Prl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21737,859,999 - 37,870,062 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1739,814,244 - 39,824,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01739,814,236 - 39,824,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01741,720,751 - 41,730,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,699,101 - 44,709,162 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11744,701,945 - 44,712,003 (-)NCBI
Celera1737,551,071 - 37,561,021 (-)NCBICelera
Cytogenetic Map17p12NCBI
Prl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554834,495,257 - 4,503,377 (+)NCBIChiLan1.0ChiLan1.0
PRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1622,450,132 - 22,465,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl622,450,132 - 22,459,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0622,109,974 - 22,125,433 (-)NCBIMhudiblu_PPA_v0panPan3
PRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,673,830 - 20,683,824 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3520,673,839 - 20,683,824 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,631,413 - 20,641,424 (-)NCBI
ROS_Cfam_1.03520,785,152 - 20,795,127 (-)NCBI
UMICH_Zoey_3.13520,591,756 - 20,601,732 (-)NCBI
UNSW_CanFamBas_1.03520,650,330 - 20,659,910 (-)NCBI
UU_Cfam_GSD_1.03522,073,534 - 22,083,124 (-)NCBI
Prl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049464,518,309 - 4,526,583 (+)NCBI
SpeTri2.0NW_0049365527,204,298 - 7,212,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl717,451,367 - 17,463,741 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1717,451,367 - 17,463,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2718,412,498 - 18,424,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11749,922,750 - 49,938,084 (+)NCBI
ChlSab1.1 Ensembl1749,928,321 - 49,938,631 (+)Ensembl
Vero_WHO_p1.0NW_02366604422,226,989 - 22,242,370 (-)NCBI
Prl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247564,585,542 - 4,593,285 (+)NCBI

Position Markers
RH46707  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,609 - 22,287,760UniSTSGRCh37
Build 36622,395,588 - 22,395,739RGDNCBI36
Celera623,520,910 - 23,521,061RGD
Cytogenetic Map6p22.2-p21.3UniSTS
HuRef622,230,786 - 22,230,937UniSTS
GeneMap99-GB4 RH Map685.38UniSTS
SHGC-132039  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,524 - 22,287,630UniSTSGRCh37
Build 36622,395,503 - 22,395,609RGDNCBI36
Celera623,520,825 - 23,520,931RGD
Cytogenetic Map6p22.2-p21.3UniSTS
HuRef622,230,701 - 22,230,807UniSTS
RH67913  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,523 - 22,287,671UniSTSGRCh37
Build 36622,395,502 - 22,395,650RGDNCBI36
Celera623,520,824 - 23,520,972RGD
Cytogenetic Map6p22.2-p21.3UniSTS
HuRef622,230,700 - 22,230,848UniSTS
GeneMap99-GB4 RH Map692.0UniSTS
NCBI RH Map6285.5UniSTS
PRL  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,483 - 22,287,584UniSTSGRCh37
Build 36622,395,462 - 22,395,563RGDNCBI36
Celera623,520,784 - 23,520,885RGD
HuRef622,230,660 - 22,230,761UniSTS
D6S1831  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,524 - 22,287,623UniSTSGRCh37
Build 36622,395,503 - 22,395,602RGDNCBI36
Celera623,520,825 - 23,520,924RGD
Cytogenetic Map6p22.2-p21.3UniSTS
HuRef622,230,701 - 22,230,800UniSTS
Stanford-G3 RH Map61061.0UniSTS
NCBI RH Map6289.6UniSTS
GeneMap99-G3 RH Map61193.0UniSTS
PRL_2831  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37622,287,376 - 22,287,887UniSTSGRCh37
Build 36622,395,355 - 22,395,866RGDNCBI36
Celera623,520,677 - 23,521,188RGD
HuRef622,230,553 - 22,231,064UniSTS


Related Rat Strains
The following Strains have been annotated to PRL

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:75
Interacting mature miRNAs:76
Transcripts:ENST00000306482
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2 1 278 5 1 277 1 1 3
Medium 139 138 117 40 119 26 198 87 168 4 158 119 14 64 135 1
Low 995 1186 581 200 755 125 1359 720 1236 83 767 655 75 639 870
Below cutoff 682 716 268 91 426 56 1318 714 930 106 214 421 36 400 827

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001163558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF056926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL023883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD106243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ305133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000306482   ⟹   ENSP00000302150
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl622,287,246 - 22,297,036 (-)Ensembl
RefSeq Acc Id: ENST00000615510   ⟹   ENSP00000478566
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl622,287,244 - 22,297,501 (-)Ensembl
RefSeq Acc Id: ENST00000617911   ⟹   ENSP00000480195
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl622,287,244 - 22,297,501 (-)Ensembl
RefSeq Acc Id: ENST00000651245   ⟹   ENSP00000498773
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl622,290,216 - 22,302,826 (-)Ensembl
RefSeq Acc Id: ENST00000651757   ⟹   ENSP00000499154
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl622,287,250 - 22,302,809 (-)Ensembl
RefSeq Acc Id: NM_000948   ⟹   NP_000939
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,287,246 - 22,297,036 (-)NCBI
GRCh37622,287,473 - 22,303,082 (-)NCBI
Build 36622,395,459 - 22,405,709 (-)NCBI Archive
HuRef622,230,650 - 22,246,259 (-)NCBI
CHM1_1622,289,298 - 22,299,569 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001163558   ⟹   NP_001157030
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,287,246 - 22,302,835 (-)NCBI
GRCh37622,287,473 - 22,303,082 (-)NCBI
HuRef622,230,650 - 22,246,259 (-)NCBI
CHM1_1622,289,298 - 22,304,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514753   ⟹   XP_011513055
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,287,246 - 22,302,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514754   ⟹   XP_011513056
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,287,246 - 22,302,897 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000939   ⟸   NM_000948
- Peptide Label: precursor
- UniProtKB: P01236 (UniProtKB/Swiss-Prot),   Q5THQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157030   ⟸   NM_001163558
- Peptide Label: precursor
- UniProtKB: P01236 (UniProtKB/Swiss-Prot),   Q5THQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011513055   ⟸   XM_011514753
- Peptide Label: isoform X1
- UniProtKB: Q5I0G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011513056   ⟸   XM_011514754
- Peptide Label: isoform X1
- UniProtKB: Q5I0G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000302150   ⟸   ENST00000306482
RefSeq Acc Id: ENSP00000499154   ⟸   ENST00000651757
RefSeq Acc Id: ENSP00000498773   ⟸   ENST00000651245
RefSeq Acc Id: ENSP00000478566   ⟸   ENST00000615510
RefSeq Acc Id: ENSP00000480195   ⟸   ENST00000617911

Promoters
RGD ID:6872172
Promoter ID:EPDNEW_H9251
Type:multiple initiation site
Name:PRL_2
Description:prolactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9252  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,297,036 - 22,297,096EPDNEW
RGD ID:6872174
Promoter ID:EPDNEW_H9252
Type:initiation region
Name:PRL_1
Description:prolactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9251  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38622,302,835 - 22,302,895EPDNEW
RGD ID:6850018
Promoter ID:EP14056
Type:single initiation site
Name:HS_PRL
Description:Prolactin, PRL gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 43; Mammalian prolactin
Tissues & Cell Lines:pituitary
Experiment Methods:Nuclease protection; Nuclease protection with homologous sequence ladder; experiments; performed with closely related gene; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Position:
Human AssemblyChrPosition (strand)Source
Build 36622,405,248 - 22,405,308EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:168775-24023234)x3 copy number gain See cases [RCV000240460] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p23-22.3(chr6:13693852-24225515)x1 copy number loss See cases [RCV000512269] Chr6:13693852..24225515 [GRCh37]
Chr6:6p23-22.3
pathogenic
GRCh37/hg19 6p22.3(chr6:22273943-22419656)x1 copy number loss not provided [RCV000682655] Chr6:22273943..22419656 [GRCh37]
Chr6:6p22.3
likely benign
Single allele duplication not provided [RCV000677944] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_000948.6(PRL):c.282C>T (p.Pro94=) single nucleotide variant not provided [RCV000946921] Chr6:22292568 [GRCh38]
Chr6:22292797 [GRCh37]
Chr6:6p22.3
benign
NM_000948.6(PRL):c.630C>T (p.Ile210=) single nucleotide variant not provided [RCV000888594] Chr6:22287456 [GRCh38]
Chr6:22287685 [GRCh37]
Chr6:6p22.3
likely benign
NM_000948.6(PRL):c.300C>T (p.Ala100=) single nucleotide variant not provided [RCV000896637] Chr6:22292550 [GRCh38]
Chr6:22292779 [GRCh37]
Chr6:6p22.3
benign
GRCh37/hg19 6p25.3-22.3(chr6:156974-23221621)x3 copy number gain not provided [RCV000848108] Chr6:156974..23221621 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
NM_000948.6(PRL):c.78G>A (p.Val26=) single nucleotide variant not provided [RCV000963864] Chr6:22294535 [GRCh38]
Chr6:22294764 [GRCh37]
Chr6:6p22.3
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9445 AgrOrtholog
COSMIC PRL COSMIC
Ensembl Genes ENSG00000172179 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000302150 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000478566 UniProtKB/TrEMBL
  ENSP00000480195 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000498773 UniProtKB/TrEMBL
  ENSP00000499154 UniProtKB/TrEMBL
Ensembl Transcript ENST00000306482 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000615510 UniProtKB/TrEMBL
  ENST00000617911 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000651245 UniProtKB/TrEMBL
  ENST00000651757 UniProtKB/TrEMBL
GTEx ENSG00000172179 GTEx
HGNC ID HGNC:9445 ENTREZGENE
Human Proteome Map PRL Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5617 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5617 ENTREZGENE
OMIM 176760 OMIM
PANTHER PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33790 PharmGKB
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494C0Z0_HUMAN UniProtKB/TrEMBL
  A0A494C1P2_HUMAN UniProtKB/TrEMBL
  A6XMH3_HUMAN UniProtKB/TrEMBL
  P01236 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5I0G2 ENTREZGENE, UniProtKB/TrEMBL
  Q5THQ0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PF72 UniProtKB/TrEMBL
  Q15199 UniProtKB/Swiss-Prot
  Q92996 UniProtKB/Swiss-Prot