Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:32168
Term: sulpiride
Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Chemical ID: MESH:D013469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDSulpiride results in increased expression of PRL mRNA, Sulpiride results in increased expression of PRL protein

PMID:21427058, PMID:26466350
increases secretionEXP 6480464CTDSulpiride results in increased secretion of PRL protein

PMID:18978642
multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [Sulpiride results in increased expression of PRL protein], Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein], Sulpiride inhibits the reaction [Cabergoline results in decreased secretion of PRL protein]

PMID:26466350, PMID:7670571
increases abundanceISORGD:7361876480464CTDSulpiride results in increased abundance of PRL protein

PMID:2954994
increases expressionISORGD:7361876480464CTDSulpiride results in increased expression of PRL protein

PMID:7106173
increases secretionISORGD:7361876480464CTDSulpiride results in increased secretion of PRL protein

PMID:2948424, PMID:3137082, PMID:3891423, PMID:4001434, PMID:7243090, PMID:956353
multiple interactionsISORGD:7361876480464CTDTriptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein], Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]

PMID:2954994, PMID:7851873
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.