PRL (prolactin) - Rat Genome Database

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Gene: PRL (prolactin) Pan paniscus
Analyze
Symbol: PRL
Name: prolactin
RGD ID: 11849094
Description: ENCODES a protein that exhibits hormone activity (inferred); metal ion binding (inferred); prolactin receptor binding (inferred); INVOLVED IN cell population proliferation (ortholog); cellular response to ethanol (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); alcohol dependence (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,921,606 - 36,937,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,921,612 - 32,937,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0622,109,974 - 22,125,433 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1622,450,132 - 22,465,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl622,450,132 - 22,459,829 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (ISO)
cellular response to ethanol  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
circadian rhythm  (ISO)
epithelial cell proliferation  (ISO)
female pregnancy  (IEA)
lactation  (IEA)
mammary gland development  (IEA,ISO)
maternal behavior  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of estrogen biosynthetic process  (ISO)
negative regulation of hydrogen peroxide biosynthetic process  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of progesterone biosynthetic process  (ISO)
ovulation cycle  (ISO)
parturition  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lactation  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
prolactin signaling pathway  (IEA)
regulation of ossification  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
response to alcohol  (ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to macrophage colony-stimulating factor  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (IEA)
response to organic cyclic compound  (ISO)
response to trichostatin A  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,921,606 - 36,937,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,921,612 - 32,937,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0622,109,974 - 22,125,433 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1622,450,132 - 22,465,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl622,450,132 - 22,459,829 (-)Ensemblpanpan1.1panPan2
PRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38622,287,246 - 22,302,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl622,287,244 - 22,302,826 (-)EnsemblGRCh38hg38GRCh38
GRCh37622,287,475 - 22,303,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36622,395,459 - 22,405,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 34622,395,458 - 22,405,709NCBI
Celera623,520,776 - 23,536,391 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef622,230,650 - 22,246,259 (-)NCBIHuRef
CHM1_1622,289,298 - 22,304,920 (-)NCBICHM1_1
T2T-CHM13v2.0622,159,710 - 22,175,312 (-)NCBIT2T-CHM13v2.0
Prl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391327,241,553 - 27,249,187 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1327,241,553 - 27,249,188 (+)EnsemblGRCm39 Ensembl
GRCm381327,057,570 - 27,065,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1327,057,570 - 27,065,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv371327,149,439 - 27,157,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361327,065,041 - 27,072,647 (+)NCBIMGSCv36mm8
Celera1327,286,739 - 27,294,373 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.25NCBI
Prl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81738,287,355 - 38,298,234 (-)NCBIGRCr8
mRatBN7.21737,859,999 - 37,870,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,860,007 - 37,870,062 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1737,943,990 - 37,954,065 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,548,006 - 39,558,081 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,831,392 - 37,841,445 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,814,236 - 39,824,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,814,244 - 39,824,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01741,720,751 - 41,730,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,699,101 - 44,709,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11744,701,945 - 44,712,003 (-)NCBI
Celera1737,551,071 - 37,561,021 (-)NCBICelera
Cytogenetic Map17p12NCBI
Prl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554834,495,257 - 4,503,377 (+)NCBIChiLan1.0ChiLan1.0
PRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,673,830 - 20,683,824 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3520,673,839 - 20,683,824 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,631,413 - 20,641,424 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03520,785,152 - 20,795,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3520,785,161 - 20,795,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13520,591,756 - 20,601,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03520,650,330 - 20,659,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03522,073,534 - 22,083,124 (-)NCBIUU_Cfam_GSD_1.0
Prl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049464,518,309 - 4,526,583 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365527,204,298 - 7,212,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl717,451,367 - 17,463,710 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1717,451,367 - 17,463,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2718,412,498 - 18,424,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11749,922,750 - 49,938,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1749,928,321 - 49,938,631 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604422,226,989 - 22,242,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247564,585,542 - 4,593,285 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000048647   ⟹   ENSPPAP00000025817
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl622,450,132 - 22,459,829 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048650   ⟹   ENSPPAP00000025820
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl622,450,290 - 22,457,361 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048651   ⟹   ENSPPAP00000025821
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl622,450,290 - 22,457,337 (-)Ensembl
RefSeq Acc Id: XM_055114422   ⟹   XP_054970397
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2536,921,610 - 36,937,224 (-)NCBI
NHGRI_mPanPan1632,921,612 - 32,937,048 (-)NCBI
RefSeq Acc Id: XM_063605067   ⟹   XP_063461137
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2536,921,606 - 36,937,124 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054970397 (Get FASTA)   NCBI Sequence Viewer  
  XP_063461137 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000025817.1
  ENSPPAP00000025820.1
  ENSPPAP00000025821.1
Ensembl Acc Id: ENSPPAP00000025817   ⟸   ENSPPAT00000048647
Ensembl Acc Id: ENSPPAP00000025820   ⟸   ENSPPAT00000048650
Ensembl Acc Id: ENSPPAP00000025821   ⟸   ENSPPAT00000048651
RefSeq Acc Id: XP_054970397   ⟸   XM_055114422
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063461137   ⟸   XM_063605067
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9P7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048647.1 UniProtKB/TrEMBL
  ENSPPAT00000048650.1 UniProtKB/TrEMBL
  ENSPPAT00000048651.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/TrEMBL
NCBI Gene PRL ENTREZGENE
PANTHER PROLACTIN UniProtKB/TrEMBL
  PTHR11417 UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/TrEMBL
PRINTS SOMATOTROPIN UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R9B9P7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BC06_PANPA UniProtKB/TrEMBL
  A0A2R9BFN6_PANPA UniProtKB/TrEMBL