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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased secretion of PRL protein], 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of and results in increased secretion of PRL protein, Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of and results in increased secretion of PRL protein]

PMID:17909072
multiple interactionsISORGD:111526480464CTD[2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein, [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein, [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein, [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form

PMID:11751460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.