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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCadmium Chloride affects the expression of PRL mRNA, Cadmium Chloride affects the expression of PRL protein

PMID:23085516
decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of PRL mRNA

PMID:19894126
increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of PRL mRNA

PMID:24236210
multiple interactionsEXP 6480464CTDCadmium Chloride results in increased expression of and results in increased secretion of PRL protein, fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PRL mRNA], Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA], Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein], Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL]

PMID:23085516, PMID:24236210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.