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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prlmultiple interactionsEXP 6480464CTDPRL protein promotes the reaction [ATP7A protein results in increased secretion of Copper]; PRL protein promotes the reaction [SLC31A1 protein results in increased secretion of Copper]PMID:16741141
Prldecreases expressionISOPRL (Homo sapiens)6480464CTDCopper results in decreased expression of PRL proteinPMID:19595304
Prlmultiple interactionsISOPRL (Homo sapiens)6480464CTDCopper inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased secretion of PRL protein]; Copper promotes the reaction [PRL protein binds to PRLR protein]PMID:32004626 PMID:6197504
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