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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCadmium results in decreased expression of PRL protein

PMID:20197452
increases expressionEXP 6480464CTDCadmium results in increased expression of PRL mRNA, Cadmium results in increased expression of PRL protein

PMID:20455018, PMID:24236210
multiple interactionsEXP 6480464CTDCadmium results in increased expression of and results in increased secretion of PRL protein, fulvestrant inhibits the reaction [Cadmium results in increased expression of PRL mRNA], Lithium inhibits the reaction [Cadmium results in increased expression of PRL protein]

PMID:20455018, PMID:24236210
decreases expressionISORGD:7361876480464CTDCadmium results in decreased expression of PRL protein

PMID:19595304
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.