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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:77733
Term: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile
Definition: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7361876480464CTDVerapamil results in increased expression of PRL protein

PMID:8845563, PMID:8977754
increases secretionISORGD:7361876480464CTDVerapamil results in increased secretion of PRL protein

PMID:20595935
multiple interactionsISORGD:7361876480464CTDVerapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]

PMID:7851873
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.