Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:31236
Term: aripiprazole
Definition: A delta-lactam that has formula C23H27Cl2N3O2.
Chemical ID: MESH:C094645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases secretionEXP 6480464CTDAripiprazole results in decreased secretion of PRL protein

PMID:8613910
increases secretionEXP 6480464CTDAripiprazole results in increased secretion of PRL protein

PMID:8613910
multiple interactionsEXP 6480464CTDAripiprazole inhibits the reaction [talipexole results in decreased secretion of PRL protein], Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]

PMID:8613910
decreases expressionISORGD:7361876480464CTDAripiprazole results in decreased expression of PRL protein

PMID:19230981, PMID:19519261
multiple interactionsISORGD:7361876480464CTDAripiprazole inhibits the reaction [haloperidol decanoate results in increased expression of PRL protein], Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]

PMID:17873694, PMID:19653986, PMID:19906340, PMID:20814333
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.