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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: A polyphenol that has formula C18H20O2.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of PRL mRNA, Diethylstilbestrol results in increased expression of PRL protein

PMID:12804517, PMID:12960047, PMID:15677882, PMID:17005392, PMID:19082791, PMID:3208992, PMID:3625096, PMID:6888657, PMID:7981127
increases secretionEXP 6480464CTDDiethylstilbestrol results in increased secretion of PRL protein

PMID:11108262, PMID:1421203, PMID:15811834, PMID:17174995, PMID:3208992, PMID:6888657
multiple interactionsEXP 6480464CTDBromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA], Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein], Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein], mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein], Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein], Progesterone inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein], vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]

PMID:1421203, PMID:15677882, PMID:15811834, PMID:17174995, PMID:19082791, PMID:3208992, PMID:3625096
increases expressionISORGD:111526480464CTDDiethylstilbestrol results in increased expression of PRL mRNA, Diethylstilbestrol results in increased expression of PRL protein

PMID:15470002, PMID:16468032
increases secretionISORGD:7361876480464CTDDiethylstilbestrol results in increased secretion of PRL protein

PMID:7168914
multiple interactionsISORGD:7361876480464CTDBromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]

PMID:7168914
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.