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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases secretionEXP 6480464CTDDopamine results in decreased secretion of PRL protein

PMID:1380082
multiple interactionsEXP 6480464CTDHaloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein], Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]

PMID:1380082
decreases expressionISORGD:7361876480464CTDDopamine results in decreased expression of PRL protein

PMID:8532072
multiple interactionsISORGD:7361876480464CTDDomperidone inhibits the reaction [Dopamine results in decreased expression of PRL protein]

PMID:8532072
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.