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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of PRL mRNA]

PMID:21187122
decreases expressionISORGD:111526480464CTDTetrachlorodibenzodioxin results in decreased expression of PRL mRNA

PMID:24793433
multiple interactionsISORGD:111526480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRL mRNA, ARNT protein inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN2 protein]], Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN1S1 mRNA], Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN2 mRNA], Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN2 protein]

PMID:17942748, PMID:25265996
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.