PRL (prolactin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: PRL (prolactin) Sus scrofa
Analyze
Symbol: PRL
Name: prolactin
RGD ID: 14116396
Description: ENCODES a protein that exhibits hormone activity (inferred); metal ion binding (inferred); INVOLVED IN cellular response to hypoxia; negative regulation of estrogen biosynthetic process; negative regulation of hydrogen peroxide biosynthetic process; ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); alcohol dependence (ortholog); FOUND IN extracellular space; extracellular region (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl717,451,367 - 17,463,710 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1717,451,367 - 17,463,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2718,412,498 - 18,424,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IBA)
cellular response to ethanol  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (IMP)
circadian rhythm  (ISO)
epithelial cell proliferation  (ISO)
female pregnancy  (IBA)
lactation  (IEA)
mammary gland development  (IBA,ISO)
maternal behavior  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of estrogen biosynthetic process  (IMP)
negative regulation of hydrogen peroxide biosynthetic process  (IMP)
negative regulation of nitric oxide biosynthetic process  (IMP)
negative regulation of progesterone biosynthetic process  (IMP)
ovulation cycle  (ISO)
parturition  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lactation  (IBA)
positive regulation of miRNA transcription  (IEA)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IMP)
prolactin signaling pathway  (IEA)
regulation of ossification  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
response to alcohol  (ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to macrophage colony-stimulating factor  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (IBA)
response to organic cyclic compound  (ISO)
response to trichostatin A  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:1270193   PMID:2344390   PMID:2726463   PMID:14559722   PMID:14681463   PMID:17145712   PMID:17463060   PMID:19675522   PMID:22301074   PMID:24530842   PMID:30032202  


Genomics

Comparative Map Data
PRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl717,451,367 - 17,463,710 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1717,451,367 - 17,463,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2718,412,498 - 18,424,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38622,287,246 - 22,302,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl622,287,244 - 22,302,826 (-)EnsemblGRCh38hg38GRCh38
GRCh37622,287,475 - 22,303,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36622,395,459 - 22,405,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 34622,395,458 - 22,405,709NCBI
Celera623,520,776 - 23,536,391 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef622,230,650 - 22,246,259 (-)NCBIHuRef
CHM1_1622,289,298 - 22,304,920 (-)NCBICHM1_1
T2T-CHM13v2.0622,159,710 - 22,175,312 (-)NCBIT2T-CHM13v2.0
Prl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391327,241,553 - 27,249,187 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1327,241,553 - 27,249,188 (+)EnsemblGRCm39 Ensembl
GRCm381327,057,570 - 27,065,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1327,057,570 - 27,065,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv371327,149,439 - 27,157,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361327,065,041 - 27,072,647 (+)NCBIMGSCv36mm8
Celera1327,286,739 - 27,294,373 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.25NCBI
Prl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81738,287,355 - 38,298,234 (-)NCBIGRCr8
mRatBN7.21737,859,999 - 37,870,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,860,007 - 37,870,062 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1737,943,990 - 37,954,065 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,548,006 - 39,558,081 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,831,392 - 37,841,445 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,814,236 - 39,824,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,814,244 - 39,824,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01741,720,751 - 41,730,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,699,101 - 44,709,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11744,701,945 - 44,712,003 (-)NCBI
Celera1737,551,071 - 37,561,021 (-)NCBICelera
Cytogenetic Map17p12NCBI
Prl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554834,495,257 - 4,503,377 (+)NCBIChiLan1.0ChiLan1.0
PRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,921,606 - 36,937,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,921,612 - 32,937,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0622,109,974 - 22,125,433 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1622,450,132 - 22,465,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl622,450,132 - 22,459,829 (-)Ensemblpanpan1.1panPan2
PRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,673,830 - 20,683,824 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3520,673,839 - 20,683,824 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,631,413 - 20,641,424 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03520,785,152 - 20,795,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3520,785,161 - 20,795,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13520,591,756 - 20,601,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03520,650,330 - 20,659,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03522,073,534 - 22,083,124 (-)NCBIUU_Cfam_GSD_1.0
Prl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049464,518,309 - 4,526,583 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365527,204,298 - 7,212,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11749,922,750 - 49,938,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1749,928,321 - 49,938,631 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604422,226,989 - 22,242,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247564,585,542 - 4,593,285 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRL
514 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 23 3 5 11 11 23 2 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000041436   ⟹   ENSSSCP00000037845
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl717,451,367 - 17,461,505 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000066158   ⟹   ENSSSCP00000032765
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl717,451,367 - 17,463,710 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000072639   ⟹   ENSSSCP00000071542
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl717,451,528 - 17,463,710 (-)Ensembl
RefSeq Acc Id: NM_213926   ⟹   NP_999091
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1717,451,386 - 17,463,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005665624   ⟹   XP_005665681
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1717,451,367 - 17,463,771 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005665681   ⟸   XM_005665624
- Peptide Label: isoform X1
- UniProtKB: A0A286ZMS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999091   ⟸   NM_213926
- Peptide Label: precursor
- UniProtKB: A0A286ZMS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000037845   ⟸   ENSSSCT00000041436
Ensembl Acc Id: ENSSSCP00000032765   ⟸   ENSSSCT00000066158
Ensembl Acc Id: ENSSSCP00000071542   ⟸   ENSSSCT00000072639


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005013825 UniProtKB/Swiss-Prot
  ENSSSCG00015006993 UniProtKB/TrEMBL
  ENSSSCG00025016163 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030013020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035002953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040002353 UniProtKB/Swiss-Prot
  ENSSSCG00045028611 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050007944 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055011670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060052812 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065029133 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070025388 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000041436 ENTREZGENE
  ENSSSCT00000041436.2 UniProtKB/TrEMBL
  ENSSSCT00000066158 ENTREZGENE
  ENSSSCT00000066158.2 UniProtKB/TrEMBL
  ENSSSCT00000072639.2 UniProtKB/TrEMBL
  ENSSSCT00005021712 UniProtKB/Swiss-Prot
  ENSSSCT00015009330.1 UniProtKB/TrEMBL
  ENSSSCT00015009377.1 UniProtKB/TrEMBL
  ENSSSCT00025021715.1 UniProtKB/Swiss-Prot
  ENSSSCT00025021746.1 UniProtKB/TrEMBL
  ENSSSCT00030017871.1 UniProtKB/Swiss-Prot
  ENSSSCT00030017892.1 UniProtKB/TrEMBL
  ENSSSCT00035003667.1 UniProtKB/Swiss-Prot
  ENSSSCT00035003672.1 UniProtKB/TrEMBL
  ENSSSCT00040002857.1 UniProtKB/Swiss-Prot
  ENSSSCT00045048844.1 UniProtKB/Swiss-Prot
  ENSSSCT00045048925.1 UniProtKB/TrEMBL
  ENSSSCT00050010841.1 UniProtKB/Swiss-Prot
  ENSSSCT00050010845.1 UniProtKB/TrEMBL
  ENSSSCT00055022983.1 UniProtKB/Swiss-Prot
  ENSSSCT00055023067.1 UniProtKB/TrEMBL
  ENSSSCT00060071878.1 UniProtKB/Swiss-Prot
  ENSSSCT00060071886.1 UniProtKB/TrEMBL
  ENSSSCT00065039329.1 UniProtKB/Swiss-Prot
  ENSSSCT00065039336.1 UniProtKB/TrEMBL
  ENSSSCT00070050742.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396965 UniProtKB/Swiss-Prot
NCBI Gene PRL ENTREZGENE
PANTHER PROLACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZMS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A287A295_PIG UniProtKB/TrEMBL
  A0A5G2R2X5_PIG UniProtKB/TrEMBL
  A0A8D0MKG2_PIG UniProtKB/TrEMBL
  A0A8D1QJW4_PIG UniProtKB/TrEMBL
  A0A8D2BMT0_PIG UniProtKB/TrEMBL
  B5A8N8_PIG UniProtKB/TrEMBL
  P01238 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:104037 ENTREZGENE