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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDresveratrol results in decreased expression of PRL protein

PMID:24669252
multiple interactionsEXP 6480464CTD[2, 3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] inhibits the reaction [Resveratrol results in decreased expression of PRL protein], [4, 4', 4''-(4-propyl-((1)H)-pyrazole-1, 3, 5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] inhibits the reaction [Resveratrol results in decreased expression of PRL protein], Estradiol inhibits the reaction [Resveratrol results in decreased expression of PRL protein], Resveratrol inhibits the reaction [Estradiol results in increased expression of PRL protein], Resveratrol results in decreased expression of and results in decreased secretion of PRL protein

PMID:22104698, PMID:24669252
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.