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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:64045
Term: amisulpride
Definition: A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects.
Chemical ID: MESH:D000077582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases secretionEXP 6480464CTDAmisulpride results in increased secretion of PRL protein

PMID:12106810
multiple interactionsEXP 6480464CTDBromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein], carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein]

PMID:12106810
increases expressionISORGD:7361876480464CTDAmisulpride results in increased expression of PRL protein

PMID:18063941
increases secretionISORGD:7361876480464CTDAmisulpride results in increased secretion of PRL protein

PMID:14966260, PMID:14997280, PMID:15665803, PMID:16938372
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.