Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:8871
Term: risperidone
Definition: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Chemical ID: MESH:D018967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases secretionEXP 6480464CTDRisperidone results in increased secretion of PRL protein

PMID:1380082
multiple interactionsEXP 6480464CTDRisperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]

PMID:1380082
increases expressionISORGD:7361876480464CTDRisperidone results in increased expression of PRL protein

PMID:11048906, PMID:11927762, PMID:15289996, PMID:15669890, PMID:16730335, PMID:17224713, PMID:18063941, PMID:18080171, PMID:19825908, PMID:19997080
increases secretionISORGD:7361876480464CTDRisperidone results in increased secretion of PRL protein

PMID:10084644, PMID:11155212, PMID:11561931, PMID:12902212, PMID:12974991, PMID:15206663, PMID:15286066, PMID:15960571, PMID:16379509, PMID:18466271, PMID:18759643, PMID:18838228, PMID:19906340, PMID:20373475, PMID:20661022, PMID:20814333, PMID:9696519, PMID:9989566
multiple interactionsISORGD:7361876480464CTD[Risperidone co-treated with Clozapine] results in increased expression of PRL protein, Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein], BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein], HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein], HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein], HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]

PMID:18562423, PMID:19653986, PMID:19906340, PMID:19997080, PMID:20814333
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.