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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD4-nonylphenol results in increased expression of PRL mRNA

PMID:19463694
increases secretionEXP 6480464CTD4-nonylphenol results in increased secretion of PRL protein

PMID:17174995, PMID:19463694
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA], fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]

PMID:19463694
increases secretionISORGD:111526480464CTD4-nonylphenol results in increased secretion of PRL protein

PMID:20950447
multiple interactionsISORGD:111526480464CTD4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein], 4-nonylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein], 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]

PMID:20950447
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.